Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls.

Björkman, Ola; Gunnarsson, R; Hagstrom, Eva; Felig, Philip; Wahren, John

doi:10.1172/jci113884

Cited by 51 publications

(35 citation statements)

References 18 publications

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“…observed following fructose ingestion in the present study 31) . Fructose has the same chemical formula as glucose, namely C6H12O6; however, its metabolism differs markedly from that of glucose due to its almost complete hepatic extraction and rapid hepatic conversion into glucose, glycogen, lactate and fat.…”

Section: Discussionsupporting

confidence: 61%

Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

Saito

Kagaya

Suzuki

et al. 2013

JAT

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Section: Discussionsupporting

confidence: 61%

Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

Saito

Kagaya

Suzuki

et al. 2013

JAT

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“…Although it is generally accepted that fructose is nearly completely metabolized at first pass in the gut and the liver (34), it remains possible that some fructose reached the systemic circulation and exerted metabolic effects directly at the level of adipocytes. Alternatively, fructose metabolism in the liver may possibly exert effects on adipose tissue through the release of metabolites such as lactate (24).…”

Section: Discussionmentioning

confidence: 99%

Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men

et al. 2005

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High-fructose diet stimulates hepatic de novo lipogenesis (DNL) and causes hypertriglyceridemia and insulin resistance in rodents. Fructose-induced insulin resistance may be secondary to alterations of lipid metabolism. In contrast, fish oil supplementation decreases triglycerides and may improve insulin resistance. Therefore, we studied the effect of high-fructose diet and fish oil on DNL and VLDL triglycerides and their impact on insulin resistance. Seven normal men were studied on four occasions: after fish oil (7.2 g/day) for 28 days; a 6-day high-fructose diet (corresponding to an extra 25% of total calories); fish oil plus high-fructose diet; and control conditions. Following each condition, fasting fractional DNL and endogenous glucose production (EGP) were evaluated using [1-13 C]sodium acetate and 6,6-2 H 2 glucose and a two-step hyperinsulinemic-euglycemic clamp was performed to assess insulin sensitivity. High-fructose diet significantly increased fasting glycemia (7 ؎ 2%), triglycerides (79 ؎ 22%), fractional DNL (sixfold), and EGP (14 ؎ 3%, all P < 0.05). It also impaired insulin-induced suppression of adipose tissue lipolysis and EGP (P < 0.05) but had no effect on wholebody insulin-mediated glucose disposal. Fish oil significantly decreased triglycerides (37%, P < 0.05) after high-fructose diet compared with high-fructose diet without fish oil and tended to reduce DNL but had no other significant effect. In conclusion, high-fructose diet induced dyslipidemia and hepatic and adipose tissue insulin resistance. Fish oil reversed dyslipidemia but not insulin resistance. Diabetes

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“…Determinations of the contribution of gluconeogenesis to glucose production in healthy subjects after an overnight fast have ranged from 25 to 70% (19,(33)(34)(35)(36)(37)(38)(39)(40)(41). That spread may be attributed in part to dietary preparation, but even with the same preparation, there has been marked variation in glycogen stores at the beginning of fasting (34).…”

Section: Discussionmentioning

confidence: 99%

Contributions of gluconeogenesis to glucose production in the fasted state.

et al. 1996

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Healthy subjects ingested 2 H 2 O and after 14, 22, and 42 h of fasting the enrichments of deuterium in the hydrogens bound to carbons 2, 5, and 6 of blood glucose and in body water were determined. The hydrogens bound to the carbons were isolated in formaldehyde which was converted to hexamethylenetetramine for assay. Enrichment of the deuterium bound to carbon 5 of glucose to that in water or to carbon 2 directly equals the fraction of glucose formed by gluconeogenesis. The contribution of gluconeogenesis to glucose production was 47 Ϯ 4% after 14 h, 67 Ϯ 4% after 22 h, and 93 Ϯ 2% after 42 h of fasting. Glycerol's conversion to glucose is included in estimates using the enrichment at carbon 5, but not carbon 6. Equilibrations with water of the hydrogens bound to carbon 3 of pyruvate that become those bound to carbon 6 of glucose and of the hydrogen at carbon 2 of glucose produced via glycogenolysis are estimated from the enrichments to be ‫ف‬ 80% complete. Thus, rates of gluconeogenesis can be determined without corrections required in other tracer methodologies. After an overnight fast gluconeogenesis accounts for ‫ف‬ 50% and after 42 h of fasting for almost all of glucose production in healthy subjects. ( J. Clin. Invest. 1996. 98:378-385.)

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Splanchnic and renal exchange of infused fructose in insulin-deficient type 1 diabetic patients and healthy controls.

Cited by 51 publications

References 18 publications

Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

Simultaneous Ingestion of Fructose and Fat Exacerbates Postprandial Exogenous Lipidemia in Young Healthy Japanese Women

Effect of Fructose Overfeeding and Fish Oil Administration on Hepatic De Novo Lipogenesis and Insulin Sensitivity in Healthy Men

Contributions of gluconeogenesis to glucose production in the fasted state.

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