Splanchnic, Thoracoabdominal, and Cerebral Blood Flow Volumes in Healthy Children and Young Adults in Fasting and Postprandial States: Determining Reference Ranges by Using Phase-Contrast MR Imaging

Muthusami, Prakash; Yoo, Shi Joon; Chaturvedi, Rajiv; Gill, Navroop; Windram, Jonathan; Schantz, Daryl; Prša, Milan; Caro‐Domínguez, Pablo; Seed, Mike; Grosse-Wortmann, Lars; Ling, Simon C.; Chavhan, Govind

doi:10.1148/radiol.2017162114

Cited by 17 publications

(8 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Moreover, the true accuracy of the phase contrast magnetic resonance angiography could not be estimated since no gold standard was available. As in the described study, same lack of reference standard for measurement of blood flow volume has been recently described in pediatric medicine . Similarly, excellent interobserver agreement was reported ( R 2 = 0.99), describing baseline data for future assessment.…”

Section: Discussionsupporting

confidence: 78%

See 1 more Smart Citation

Cardiac‐gated, phase contrast magnetic resonance angiography is a reliable and reproducible technique for quantifying blood flow in canine major cranial abdominal vessels

Chicca

Schwarz

Grest

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

Blood flow changes in cranial abdominal vessels are important contributing factors for canine hepatic disease. This prospective, experimental, pilot study aimed to evaluate cardiac-gated, phase contrast magnetic resonance angiography (PCMRA) as a method for characterizing blood flow in canine major cranial abdominal vessels. Eleven, healthy, adult beagle dogs were sampled. Cardiac-gated, phase contrast magnetic resonance angiography of the cranial abdomen was performed in each dog and blood flow was independently measured in each of the major cranial abdominal vessels by three observers, with two observers recording blood flow values once and one observer recording blood flow values three times. Each dog then underwent ultrasonographic examination of the liver with fine needle aspirations and biopsies submitted to cytologic and histologic examination. The mean absolute stroke volume and velocity were respectively 9.6 ± 1.9 ml and -11.1 ± 1.1 cm/s for the cranial abdominal aorta, 2.1 ± 0.6 ml and -6.6 ± 1.9 cm/s for the celiac artery, and 2.3 ± 1.0 ml and -7.9 ± 3.1 cm/s for the cranial mesenteric artery. The mean absolute stroke volume and velocity were respectively 6.7 ± 1.3 ml and 3.9 ± 0.9 cm/s for the caudal vena cava and 2.6 ± 0.9 ml and 3.2 ± 1.2 cm/s for the portal vein. Intraobserver reliability was excellent (intraclass correlation coefficient > 0.9). Interobserver reproducibility was also excellent (intraclass correlation coefficient 0.89-0.99). Results of liver ultrasonography, cytology, and histopathology were unremarkable. Findings indicated that cardiac-gated, phase contrast magnetic resonance angiography is a feasible technique for quantifying blood blow in canine major cranial abdominal vessels. Blood flow values from this sample of healthy beagles can be used as background for future studies on canine hepatic disease.

show abstract

Section: Discussionsupporting

confidence: 78%

“…As in the described study, same lack of reference standard for measurement of blood flow volume has been recently described in pediatric medicine. 49 Similarly, excellent interobserver agreement was reported (R 2 = 0.99), describing baseline data for future assessment.…”

Section: Discussionmentioning

confidence: 73%

Cardiac‐gated, phase contrast magnetic resonance angiography is a reliable and reproducible technique for quantifying blood flow in canine major cranial abdominal vessels

Chicca

Schwarz

Grest

et al. 2018

Vet Radiology Ultrasound

View full text Add to dashboard Cite

show abstract

“…These measurements at the base of the skull are fast to perform with a scan time of less than a minute providing the volume flow in milliliters/minute [4, 9, 11]. Formerly, reference values for PC-MRA determined CBF in children have only been presented in smaller cohorts [12, 13]. …”

Section: Introductionmentioning

confidence: 99%

Cerebral Blood Flow Measured by Phase-Contrast Magnetic Resonance Angiography in Preterm and Term Neonates

et al. 2019

View full text Add to dashboard Cite

Background: Preterm infants show a decreased tortuosity in all proximal segments of the cerebral vasculature at term-equivalent age (TEA). Recently MRI techniques were developed to measure cerebral blood flow (CBF) based on phase-contrast images. Objectives: We hypothesized that arterial CBF corrected for brain size differs between full-term and preterm infants at TEA. Methods: 344 infants without major brain abnormalities had a cranial MRI for clinical reasons including phase-contrast magnetic resonance angiography (PC-MRA) around TEA (mean 41.1 ± SD 1.2 weeks). This cohort consisted of 172 preterm infants (gestational age at birth 24.1–31.9 weeks) and 172 term-born infants (gestational age at birth 37.0–42.6 weeks). The total CBF in milliliters/minute was calculated by adding the blood flow of the carotid and basilar arteries, and compared to age at scan, body weight, and several parameters of estimated brain size. Results: After logarithmic transformation, total CBF was associated with body weight, estimated brain weight, head circumference, and 2D brain surface measurements at TEA. Total CBF was significantly (9–12%) higher in term compared to preterm infants after correction for 2D brain surface measurements, head circumference or postmenstrual age at MRI (p < 0.05). Conclusions: Total CBF as measured by PC-MRA was associated with body and (estimated) brain weight and 2D brain surface measurements and was higher in term compared to preterm born infants.

show abstract

“…We identified 39 children (18 females and 21 males; mean age, 9.3 years; age range, 3.3–17.0 years), including 15 with fenestrated Fontan circulation and 24 with completed Fontan circulation who underwent PCMRI of the thoracic and abdominal major vessels as a part of their MRI assessment. The patients' blood flow data from PCMRI were compared with those from 19 healthy children (12 females and 7 males; mean age, 13.6 years; age range, 9.0–17.0 years) who were included in a previous study (10). MRI was performed under general anesthesia (GA) in all patients with fenestrated Fontan circulation and 6 patients with completed Fontan circulation.…”

Section: Methodsmentioning

confidence: 99%

“…MRI was performed under general anesthesia (GA) in all patients with fenestrated Fontan circulation and 6 patients with completed Fontan circulation. The remaining 18 patients with completed Fontan circulation underwent MRI without GA. All healthy volunteers underwent MRI without GA in a fasting state and at 20–30 minutes after a standardized meal, as described in the previous study (10).…”

Section: Methodsmentioning

confidence: 99%

Magnetic Resonance Imaging Assessment of Blood Flow Distribution in Fenestrated and Completed Fontan Circulation with Special Emphasis on Abdominal Blood Flow

et al. 2019

Self Cite

View full text Add to dashboard Cite

Objective To investigate the regional flow distribution in patients with Fontan circulation by using magnetic resonance imaging (MRI). Materials and Methods We identified 39 children (18 females and 21 males; mean age, 9.3 years; age range, 3.3–17.0 years) with Fontan circulation in whom flow volumes across the thoracic and abdominal arteries and veins were measured by using MRI. The patients were divided into three groups: fenestrated Fontan circulation group with MRI performed under general anesthesia (GA) (Group 1, 15 patients; average age, 5.9 years), completed Fontan circulation group with MRI performed under GA (Group 2, 6 patients; average age, 8.7 years), and completed Fontan circulation group with MRI performed without GA (Group 3, 18 patients; average age, 12.5 years). The patient data were compared with the reference ranges in healthy controls. Results In comparison with the controls, Group 1 showed normal cardiac output (3.92 ± 0.40 vs. 3.72 ± 0.69 L/min/m 2 , p = 0.30), while Group 3 showed decreased cardiac output (3.24 ± 0.71 vs. 3.96 ± 0.64 L/min/m 2 , p = 0.003). Groups 1 and 3 showed reduced abdominal flow (1.21 ± 0.28 vs. 2.37 ± 0.45 L/min/m 2 , p < 0.001 and 1.89 ± 0.39 vs. 2.64 ± 0.38 L/min/m 2 , p < 0.001, respectively), which was mainly due to the diversion of the cardiac output to the aortopulmonary collaterals in Group 1 and the reduced cardiac output in Group 3. Superior mesenteric and portal venous flows were more severely reduced in Group 3 than in Group 1 (ratios between the flow volumes of the patients and healthy controls was 0.26 and 0.37 in Group 3 and 0.63 and 0.53 in Group 1, respectively). Hepatic arterial flow was decreased in Group 1 (0.11 ± 0.22 vs. 0.34 ± 0.38 L/min/m 2 , p = 0.04) and markedly increased in Group 3 (0.38 ± 0.22 vs. −0.08 ± 0.29 L/min/m 2 , p < 0.0001). Group 2 showed a mixture of the patterns seen in Groups 1 and 3. Conclusion Fontan circulation is associated with reduced abdominal flow, which can be attributed to reduced cardiac output and portal venous return in completed Fontan circulation, and diversion of the cardiac output to the aortopulmonary collaterals in fenestrated Fontan circulation.

show abstract

Splanchnic, Thoracoabdominal, and Cerebral Blood Flow Volumes in Healthy Children and Young Adults in Fasting and Postprandial States: Determining Reference Ranges by Using Phase-Contrast MR Imaging

Cited by 17 publications

References 30 publications

Cardiac‐gated, phase contrast magnetic resonance angiography is a reliable and reproducible technique for quantifying blood flow in canine major cranial abdominal vessels

Cardiac‐gated, phase contrast magnetic resonance angiography is a reliable and reproducible technique for quantifying blood flow in canine major cranial abdominal vessels

Cerebral Blood Flow Measured by Phase-Contrast Magnetic Resonance Angiography in Preterm and Term Neonates

Magnetic Resonance Imaging Assessment of Blood Flow Distribution in Fenestrated and Completed Fontan Circulation with Special Emphasis on Abdominal Blood Flow

Contact Info

Product

Resources

About