Splanchnic tissues respond differently when piglets are offered a diet 30 % deficient in total sulfur amino acid for 10 days

Conde-Aguilera, Jose Alberto; Floc'H, Nathalie Le; Huërou‐Luron, Isabelle Le; Mercier, Yves; Tesseraud, Sophie; Lefaucheur, Louis; Milgen, Jaap van

doi:10.1007/s00394-015-1031-x

Cited by 11 publications

(11 citation statements)

References 50 publications

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“…Therefore, high AA efficiency of utilization might result from the fact that these efficiencies values were obtained through a back calculation using the observed PD in the pigs but assuming the Lys concentration constant as 6.9% of the protein. This constant AA concentration in protein seems to be an invalid assumption, given that protein and energy levels [39], age [11], sulfur AA deficiency [12, 40], Thr deficiency [13] or excess, and genetics [41] can change body AA composition. The most metabolically efficient pigs may use several mechanisms, such as decreased protein degradation, increased AA absorption in the small intestinal tissue, and increased absorption of AAs from plasma proteins, to cope with lower AA intake, thereby contributing to the higher AA efficiency.…”

Section: Discussionmentioning

confidence: 99%

“…Threonine (Thr) is often the second-limiting AA in conventional commercial diets, and feeding pigs AA deficient diets limit protein deposition (PD) and affects tissue protein composition [11, 12]. Thus, Thr deficiency might lead to the synthesis of proteins with less Thr and a reduction of the Thr concentration in the overall body muscles [13].…”

Section: Introductionmentioning

confidence: 99%

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Pigs receiving daily tailored diets using precision-feeding techniques have different threonine requirements than pigs fed in conventional phase-feeding systems

Remus

Hauschild

Corrent³

et al. 2019

J Animal Sci Biotechnol

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Background There is large variation in amino acids requirements among pigs, hence feeding pigs individually with daily tailored diets or in groups with a single feed may require different levels of nutrients. Thus, the response to different threonine levels (70%, 85%, 100%, 115%, and 130% of the ideal threonine:lysine protein ratio of 0.65) was studied in growing pigs raised in a conventional group phase-feeding (GPF) system or fed individually using individual precision-feeding (IPF) techniques. In a 21-day trial, 110 barrows (25 ± 0.80 kg body weight) were housed in the same room and fed using electronic feeders. Five pigs per treatment were slaughtered at the end of the trial. Results Threonine intake increased linearly for the IPF and GPF pigs ( P < 0.05). Lysine intake was similar across the treatments. Average daily gain, gain:feed ratio, and protein deposition were affected linearly by threonine level ( P < 0.05) in both feeding systems. Protein deposition in the GPF pigs was maximized at 150 g/d and a 0.65 threonine:lysine ratio, whereas protein deposition increased linearly in the IPF pigs. Plasma Met and serine levels were 11 and 7% higher, respectively, in the IPF pigs than in the GPF pigs ( P < 0.05). Dietary threonine increased ( P < 0.05) threonine concentration in the longissimus dorsi in a quadratic manner in the IPF pigs, whereas there was no effect in the GPF pigs. Longissimus dorsi collagen decreased as dietary threonine increased in the IPF and GPF pigs ( P < 0.10). Carcass muscle crude protein was 2% higher in the GPF pigs than in the IPF pigs ( P < 0.05). Conclusions Individual pigs are able to modulate growth and the composition of growth according to threonine intake. The average amino acid ratio value that is currently used for GPF cannot be used for IPF.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Pigs receiving daily tailored diets using precision-feeding techniques have different threonine requirements than pigs fed in conventional phase-feeding systems

Remus

Hauschild

Corrent³

et al. 2019

J Animal Sci Biotechnol

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“…Livestock husbandry practices have prompted an expanded use of synthetic amino acids in animal diets to enhance the performance and carcass quality of livestock, as well as to minimize the environmental impact caused by nitrogen excretion [1][2][3][4]. This is true for methionine, which is an essential amino acid for all livestock species, and it is the first limiting amino acid in diets for poultry and the second or third limiting amino acid in the corn-soybean meal diets for pigs [5,6]. Methionine is not only used for protein synthesis, but it is also involved in the methylation reactions of DNA [7,8] and in choline metabolism [9,10].…”

Section: Introductionmentioning

confidence: 99%

Increased Consumption of Sulfur Amino Acids by Both Sows and Piglets Enhances the Ability of the Progeny to Adverse Effects Induced by Lipopolysaccharide

Zhang

Zhao

et al. 2019

Animals

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This study determined the effects of increased consumption of sulfur amino acids (SAA), as either DL-Met or Hydroxy-Met (OH-Met), by sows and piglets on their performance and the ability of the progeny to resist a lipopolysaccharide (LPS) challenge. Thirty primiparous sows were fed a diet adequate in SAA (CON) or CON + 25% SAA, either as DL-Met or OH-Met from gestation day 85 to postnatal day 21. At 35 d old, 20 male piglets from each treatment were selected and divided into 2 groups (n = 10/treatment) for a 3 × 2 factorial design [diets (CON, DL-Met or OH-Met) and challenge (saline or LPS)]. OH-Met and/or DL-Met supplementation increased (p ≤ 0.05) piglets’ body weight gain during day 0–7 and day 7–14. Sow’s milk quality was improved in the supplemented treatments compared to the CON. The LPS challenge decreased (p ≤ 0.05) piglets’ performance from 35 to 63 d and increased (p ≤ 0.05) the levels of aspartate aminotransferase, total bilirubin, IL-1β, IL-6, TNF-a, and malondialdehyde. Plasma albumin, total protein, total antioxidant capacity and glutathione peroxidase decreased post-challenge. The results were better with OH-Met than DL-Met. The increase of Met consumption, particularly as OH-Met increased piglets’ growth performance during the lactation phase and the challenging period.

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“…The dietary supplementation of methionine was found to improve intestinal integrity in weanling piglets (Chen et al 2014). Additionally, the growth and development of the small intestine could be damaged by sulfur amino acid deficiency, as reported by the previous studies (Conde-Aguilera et al 2016). Sulfur amino acid deficiency also decreased antioxidant capacity in piglets by reducing GSH and cysteine concentrations (Bauchart-Thevret et al 2009).…”

Section: Introductionmentioning

confidence: 55%

Effects of subchronic methionine stimulation on oxidative status and morphological changes in the rat ileum

Todorović

Stojanović²,

Šćepanović³

et al. 2019

gpb

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This study was conducted to explore the effects of sulfur containing amino acids on redox status and morphological parameters in the rat ileum tissue. Male Wistar albino rats were randomly divided into the following groups: K group (saline, 1 ml/day, i.p.), M group (methionine, 0.8 mmol/ kg/day, i.p.), C group (methionine (0.8 mmol/kg/day) + L-cysteine (7 mg/kg/day), i.p.) and N group (methionine (0.8 mmol/kg/day) + N-acetyl-L-cysteine (50 mg/kg/day), i.p.). Activities of antioxidant enzymes in the ileum were analyzed to profile oxidative status. Morphometric analysis included measurement of villus height (μm), tunica mucosa thickness (μm), tunica muscularis thickness (μm), the total thickness of the ileal wall (μm) and the number of cells in the lamina propria (per 0.1 mm 2 of tissue). Results showed that methionine treatment reduced the activity of antioxidant enzymes (SOD, GPx, CAT) and the GSH content compared to the control group (p > 0.05). The application of methionine reduced the following parameters statistically significant compared to the control group: length of the ileal villi (p < 0.01), tunica mucosa thickness (p < 0.01), and ileal wall thickness (p < 0.01). We concluded that methionine induced the changes in the gut redox status, which implied oxidative stress occurrence. L-cysteine and N-acetyl-L-cysteine both exhibited antioxidant properties.

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Splanchnic tissues respond differently when piglets are offered a diet 30 % deficient in total sulfur amino acid for 10 days

Cited by 11 publications

References 50 publications

Pigs receiving daily tailored diets using precision-feeding techniques have different threonine requirements than pigs fed in conventional phase-feeding systems

Pigs receiving daily tailored diets using precision-feeding techniques have different threonine requirements than pigs fed in conventional phase-feeding systems

Increased Consumption of Sulfur Amino Acids by Both Sows and Piglets Enhances the Ability of the Progeny to Adverse Effects Induced by Lipopolysaccharide

Effects of subchronic methionine stimulation on oxidative status and morphological changes in the rat ileum

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