Splenectomy for Chronic Idiopathic Thrombocytopenic Purpura

Immune thrombocytopenic purpura does not exhibit a disparity in prevalence between African American and white veterans

“…on April 29, 2019. by guest www.bloodjournal.org From important social differences influencing medical access or diverse cultural practices with consequences for health care delivery and outcomes. It is therefore crucial to confirm conclusions about putative racial disparities with well-grounded assessments derived from large population-based data to avoid erroneous conclusions.A recent review of previous small studies [4][5][6][7][8][9][10] reported that the proportion of African American patients with immune thrombocytopenic purpura (ITP) was very low compared with the proportion of African Americans in the population. If that is the case, further investigation of environmental, social, and genetic factors that contribute would be a priority.…”

“…[3][4][5][6][7][8] Coexpression of the CXCR5 chemokine receptor and its ligand CXCL13 suggests an autocrine loop, possibly contributing to the survival of neoplastic T cells. All cases demonstrated coexpression of CD154 in the majority of the neoplastic T cells.…”

“…A recent review of previous small studies [4][5][6][7][8][9][10] reported that the proportion of African American patients with immune thrombocytopenic purpura (ITP) was very low compared with the proportion of African Americans in the population. If that is the case, further investigation of environmental, social, and genetic factors that contribute would be a priority.…”

Is immune thrombocytopenic purpura less common among black Americans?

“…Therefore, we systematically searched the Medline database for all publications on ITP from the United States to identify articles describing 10 or more patients that identified patients by race; we found only 6 articles. [2][3][4][5][6][7] These articles report data from different regions of the United States and across many years.…”

“…In 5 of the published studies, the 95% confidence interval (CI) for the observed percent of blacks among the ITP patients did not overlap with the percentage of blacks in the population. [2][3][4]6,7 One of these articles commented on their observation that only 4 (6%) of 67 patients with ITP were black, compared with 25% of their hospital patients. 2 A potential limitation of this study is our selection of census data.…”