Splenic abnormalities: a comparative review of ultrasound, microbubble-enhanced ultrasound and computed tomography

Peddu, Praveen; Shah, Mohit; Sidhu, Paul S.

doi:10.1016/j.crad.2004.01.007

Cited by 64 publications

(59 citation statements)

References 48 publications

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“…In our patient, B-mode sonography revealed splenomegaly with hyperechoic nodes and a probable splenic infarct. The average spleen measures about 110e120 mm (length) by 70 mm (width) by 40 mm (thickness) and weighs 150e200 g. Splenomegaly may accompany certain infections, and it may also be caused by tumors, blood sequestration, blood supply disorders, or portal hypertension [12,13]. Compared with other parenchymal organs, the spleen is rarely the site of primary focal lesions [14], whose prevalence in the general population is estimated at 0.1% [15].…”

Section: Discussionmentioning

confidence: 99%

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Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann–Pick disease: an atypical hemangioma enhancement pattern

Benedetti

Proietti

Miccoli

et al. 2009

Journal of Ultrasound

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KEYWORDSCEUS; NiemannePick disease; Nodular splenomegaly.Abstract Introduction: NiemannePick disease (NPD) types A and B are lipid storage disorders. NPD type A is a fatal disorder of infancy. Type B is a non-neuronopathic form observed in children and adults. It is associated with enlargement of the liver, spleen, or both, and nodular splenomegaly may be detected with ultrasound. Methods: A 21-year-old female was admitted to the Emergency Room with fever, pharyngitis, and left upper quadrant abdominal pain. Labwork revealed anemia, thrombocytopenia, increased levels of AST, ALT, GGT, AF, LDH, triglycerides, and total cholesterol and low levels of HDL-cholesterol. PCR blood assays for CMV and EBV were both negative. Chest X-ray was unremarkable. Transabdominal B-mode ultrasound (US) revealed splenomegaly (long axis: >22 cm), an irregular subcapsular hypoechoic lesion in the superior pole that was consistent with splenic infarction, and multiple round highly echogenic nodes measuring 1e5 cm in diameter. Contrast-enhanced ultrasonography (CEUS) was performed using SonoVue â (Bracco). Results: The presence of a splenic infarction was confirmed. The nodular lesions showed arterial-phase enhancement with late parenchymal phase wash-out. 18 F-FDG-PET revealed splenic * Corresponding author. Dipartimento di Oncologia, dei Trapianti e delle nuove Tecnologie in Medicina, Divisione di Ematologia Università di Pisa, Via Roma 67, 56126 Pisa, Italy.E-mail address: emilia@ipcf.cnr.it (E. Benedetti). nodular uptake. Primary splenic lymphoma was suspected, and the patient underwent open splenectomy. The diagnosis was type B NPD with splenic hemangiomas. Discussion: CEUS confirmed the diagnosis and extent of splenic infarction, but the nodular atypical enhancement pattern together with nodular 18 F-FDG-PET uptake was misleading, suggesting as it did lymphoproliferative involvement of the spleen.Sommario Introduzione: La malattia di Niemann-Pick (NPD) tipo A e B è una patologia da accumulo di lipidi. Il tipo A è un disordine fatale dell'infanzia. Il tipo B è una forma non-neuronopatica ossevata sia nei bambini che negli adulti con possibile riscontro di epatomegalia e/o splenomegalia (nodulare) durante un esame ecografico. Il tipo C dipende da un difetto nel trasporto del colesterolo. Metodi: Una donna di 21 anni si è presentata al Pronto Soccorso con febbre, faringodinia e dolore al quadrante addominale superiore sinistro. Gli esami ematochimici hanno evidenziato anemia, piastrinopenia, aumento delle AST, ALT, GGT, FA, LDH trigliceridi, colesterolo totale, e ridotto HDL. La PCR per CMV ed EBV era negativa. La radiografia del torace era negativa. L'ecografia transaddominale ha rilevato splenomegalia (>22 cm long axis) con una lesione ipoecogena irregolare subcapsulare al polo superiore compatibile con infarto splenico e la presenza di multiple lesioni nodulari iperecogene con diametro da 1 cm fino a 5. Risultati: È stata quindi eseguita una ecografia con mezzo di contrasto con SonoVue â (Bracco) che ha confermato la presenza di u...

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Section: Discussionmentioning

confidence: 99%

“…Highly reflective, complex lesions and ''target sign'' lesions have also been described, but are uncommon [13].…”

Section: Discussionmentioning

confidence: 99%

Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann–Pick disease: an atypical hemangioma enhancement pattern

Benedetti

Proietti

Miccoli

et al. 2009

Journal of Ultrasound

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“…Occasionally, the lesions display increased through transmission [ 41 ]. With contrast administration, lymphomatous lesions are hypoechoic with irregular peripheral enhancement [ 45 ] and become more hypoechoic relative to normal splenic parenchyma as a function of time [ 11 , 49 ]. The sensitivity and specifi city of ultrasound for detecting and diagnosing splenic lymphoma are 54 and 100 %, respectively [ 48 ].…”

Section: Lymphomamentioning

confidence: 99%

Splenic Lesions

Gupta

Deshmukh

Ditzler

et al. 2013

Functional Imaging in Oncology

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“…Disseminated intravascular coagulation was defined as a fibrinogen level of <100 mg/dL and prolonged prothrombin (PT) and partial thromboplastin (PTT) times. Splenomegaly was defined as a spleen measured as >11 cm on ultrasound or computed tomography [29]. Renal failure was defined as a serum creatinine level of ≥1.5 mg/dL.…”

Section: Methodsmentioning

confidence: 99%

Extended Small-Dose Platelet Transfusions in Multitransfused Hemato-Oncological Patients: A Single-Center Experience

Gurevich-Shapiro

Tzadok²,

Rosenberg³

et al. 2017

Acta Haematol

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Background: Refractoriness to platelet transfusion, prevalent among 15-20% of hemato-oncological patients, is associated with multitransfusions and inferior outcomes. We evaluated the effectiveness of extended slow-dose transfusion (ESDT) in increasing platelet increments in multitransfused patients. Methods: Patients treated after the implementation of ESDT were compared with historical controls treated with standard single-donor platelet (SDP) transfusions. Cohorts of early and late recipients were assembled for comparison, i.e. the 8th or 9th and 11th platelet unit per patient, respectively. Patients in the ESDT group received transfusions equal to half an SDP unit, administered over 4 h. Effectiveness was defined as a higher corrected count increment (CCI) at 1, 12, and 24 h after transfusion. Results: In the early-recipients cohort, 24-h-posttransfusion increments were available for 29 ESDT patients and 6 standard patients, and did not differ significantly between the groups (p = 0.078). The 24-h-posttransfusion increment was available for 20 ESDT patients and 7 standard patients in the late-recipients cohort. The CCI was significantly higher in the ESDT group (p = 0.042). ABO compatibility improved the CCI (p = 0.01). Conclusions: ESDT demonstrated slightly higher increments at 24 h after transfusion in late recipients, suggesting this could be a cost-effective approach for the treatment of thrombocytopenic multitransfused hemato-oncological patients.

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Splenic abnormalities: a comparative review of ultrasound, microbubble-enhanced ultrasound and computed tomography

Cited by 64 publications

References 48 publications

Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann–Pick disease: an atypical hemangioma enhancement pattern

Contrast-enhanced ultrasonography in nodular splenomegaly associated with type B Niemann–Pick disease: an atypical hemangioma enhancement pattern

Splenic Lesions

Extended Small-Dose Platelet Transfusions in Multitransfused Hemato-Oncological Patients: A Single-Center Experience

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