Splenic Metastasis of Squamous Cell Carcinoma of the Uterine Cervix: A Case Report and Review of the Literature

Abstract

Metastasis from various neoplasms to the spleen is very rare and most of the cases are found at autopsy. We report a patient presenting with uterine cervical cancer with splenic metastases. A 49-year-old woman presenting with genital bleeding was referred to our hospital and diagnosed with stage IIB cervical cancer. She underwent concomitant chemoradiotherapy (CCRT) consisting of 50 Gy whole pelvis irradiation, high-dose-rate intracavitary brachytherapy 24 Gy/4 fractions and six weeks of paclitaxel and carboplatin administration. Ten months after the initial therapy, CT revealed recurrence at spleen. Although she received 5 courses of nedaplatin, enlargement of the tumor was noticed. She underwent a splenectomy and the result of histology was compatible with metastasis of cervical cancer.

Splenic Metastasis from Cancer of Uterine Cervix—a Rare Case

“…Solitary splenic metastasis from squamous cell carcinoma of uterine cervix was first reported by Brufman et al in 1977 [15]. As per our knowledge, 11 cases of squamous cell carcinoma metastatic to spleen without evidence of disseminated disease have been reported [9,[15][16][17][18][19][20][21][22][23][24]. Our case is possibly the 12th reported case.…”

The clinical course and management of cervical cancer with splenic metastasis: Case report and review of the literature

“…As reported in the literature, the incidence of splenic metastases from cervical cancer ranged from 1/92 to 8/108 in autopsy cases 4 . To the best of our knowledge, only 17 cases of splenic metastasis resulting from cervical cancer have been reported in the literature (Supplementary Table ), including ours 5‐15 . The stages of the 17‐splenic metastasis retrieved from the literature were as follows: 11.76% (2/17) in stage IB, 23.53% (4/17) in stage IIA, 47.06% (8/17) in stage IIB, 5.88% (1/17) in stage IIIB, and 5.88%(1/17) in stage IVA.…”

Solitary splenic metastasis in a case of treated cervical cancer: a case report

“…15 Advances in chemotherapy, irradiation, and surgical treatment have resulted in better control of disease and longer survival and has also led to decreased incidences of distant metastases. 16…”