Splenic rupture as the presenting manifestation of vasculitis

McCain, Michelle; Quinet, Robert; Davis, William E.; Serebro, Leonard; Zakem, Jerald; Nair, P. K. R.; Ishaq, Saliha

doi:10.1053/sarh.2002.30636

Cited by 15 publications

(13 citation statements)

References 13 publications

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“…Other conditions reported in the paediatric age group include severe meningococcal septicaemia [11], congenital afibrinogenemia [12] and malaria [13]. An increased risk for pathologic splenic ruptures has also been reported in patients with systemic vasculitis [14,15] and several rheumatic conditions [3]. Many of these disorders lead to an altered organ consistency or enlargement, destroy the splenic capsule, alter local circulation or decrease fibrin stability, making the spleen more fragile or engendering a greater mass effect in decelerating trauma, thus, causing an increased risk and severity of splenic injury, even after trivial traumata [16].…”

Section: Discussionmentioning

confidence: 99%

Life-threatening spontaneous splenic rupture with systemic lupus erythematosus: case report and literature review

et al. 2012

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Although involvement of the reticuloendothelial system in systemic lupus erythematosus (SLE) is a well-recognised concomitant of the disease, spontaneous splenic rupture is an unusual occurrence. We observed a 54-year-old woman with SLE who had spontaneous splenic rupture during the late course of the disease and showed some changes histopathologically. The courses and the clinical characteristics of such patients are reviewed, and the diagnosis and treatment of these cases are discussed. Early evaluation for SLE patients with spontaneous splenic rupture should be considered and included in the differential diagnosis of acute abdomen, as it may affect follow-up and treatment, although the condition is rare.

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Section: Discussionmentioning

confidence: 99%

Life-threatening spontaneous splenic rupture with systemic lupus erythematosus: case report and literature review

et al. 2012

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“…The causal relationship to splenic rupture is not clear, but the close localization of sarcoidal granulomas to vessels might lead to focal circulation abnormalities and microinfarctions. Indeed, such patients had additional intraparenchymatous hemorrhages which are rather typical for vasculitis [13][14][15]22] . Like in other organs, sarcoidosis should be a diagnosis of exclusion.…”

Section: Discussionmentioning

confidence: 99%

Splenic Rupture, Beyond and Behind: A Histological, Morphometric and Follow-Up Study of 254 Cases

Sterlacci

Heiss²,

Augustin³

et al. 2006

Pathobiology

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Objective: Population-based data regarding splenic rupture causes are sparse. To systematically characterize histology and morphometry of splenic rupture, we performed a retrospective clinicopathological study of 254 patients. Methods: Our electronic data base was reviewed and all splenic rupture cases were morphologically, morphometrically and, where needed, molecularly analyzed. Clinical and follow-up data were gained by reviewing patient charts. A formula to calculate splenic volume based on size was established and results were compared to the actual volumes. Results: Ruptured spleens presented 0.1% of all gross surgical pathology specimens. Nearly 90% were due to trauma and approximately 10% were pathologic, being associated with underlying diseases (5% with unexpected diseases) such as splenic angiomas, granulomatous diseases, infarctions, hepatopathies, cysts, hemorrhagic diatheses, hematological neoplasms, metastatic carcinoma and collagenosis. Men were more often affected than women. Morphometric analysis showed distinct splenic weights, volumes and capsule thicknesses with respect to the different rupture causes. Pathological ruptures were predominantly observed in elderly, male patients with larger spleens. Conclusions: Splenic rupture is due to an often unexpected underlying disease in approximately 10% of the cases. This should be kept in mind when dealing with susceptible patient groups.

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“…A search of the PubMed database identified only three documented cases of spontaneous splenic rupture in GPA. [2][3][4] In all three cases rupture was the first presenting sign of GPA. The present case is unique in that splenic rupture developed after the diagnosis of GPA and during treatment with corticosteroids.…”

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confidence: 76%

“…The pathologic splenic changes associated with GPA include necrotizing granulomatous inflammation, vasculitis, fibrinoid change of blood vessels and infarction. 1 Although extremely rare, with only three published cases to date, [2][3][4] spontaneous splenic rupture may occur as a complication in GPA. Here, we report a fourth case of spontaneous splenic rupture, which occurred during treatment for GPA with corticosteroids.…”

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confidence: 99%

Spontaneous splenic rupture complicating granulomatosis with polyangiitis (Wegener's granulomatosis)

et al. 2013

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Splenic rupture as the presenting manifestation of vasculitis

Cited by 15 publications

References 13 publications

Life-threatening spontaneous splenic rupture with systemic lupus erythematosus: case report and literature review

Life-threatening spontaneous splenic rupture with systemic lupus erythematosus: case report and literature review

Splenic Rupture, Beyond and Behind: A Histological, Morphometric and Follow-Up Study of 254 Cases

Spontaneous splenic rupture complicating granulomatosis with polyangiitis (Wegener's granulomatosis)

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