Splicing factor SRSF2-centric gene regulation

Li, Kun; Wang, Ziqiang

doi:10.7150/ijbs.58888

Cited by 27 publications

(14 citation statements)

References 89 publications

(99 reference statements)

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“…SRSF2 (serine and arginine rich splicing factor 2; also known as SFRS2) gene plays vital roles in a number of biological and pathological processes and it is associated in humans with the progression of a variety of diseases, including viral infection and tumorigenesis 60 .…”

Section: Discussionmentioning

confidence: 99%

Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy)

Fabbri

Crovetti

Tinacci

et al. 2022

Sci Rep

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Wild boar (Sus scrofa L.) is one of the large mammals most spread worldwide, highly adaptable, and its population rapidly increased in many areas in Europe, including Italy, where Tuscany is considered particularly suitable for wild boar. Wild boars are potential hosts for different etiological agents, such as Brucella spp., Leptospira spp. and Pseudorabies virus and they can contribute to maintain and/or to disseminate some bacterial or viral pathogens to humans and domestic animals, above all-in free-range farms. In order to identify hypothetical genomic regions associated with these infection diseases, 96 samples of wild boars hunted in Tuscany during the 2018–2019 and 2019–2020 hunting seasons were considered. Diagnosis was achieved by serological tests and 42 Pseudorabies, 31 Leptospira and 15 Brucella positive animals were identified. All animals were genotyped with Geneseek Genomic Profiler Porcine HD (70 k) and a genome-wide scan was then performed. Significant markers were highlighted for Pseudorabies (two SNPs), Brucella (seven SNPs), and Leptospira (four SNPs) and they were located within, or nearby, 29 annotated genes on chromosome 6, 9, 12, 13, 14 and 18. Eight genes are implicated in viral (SEC14L1, JMJD6, SRSF2, TMPRSS2, MX1, MX2) or bacterial (COL8A1, SPIRE1) infections, seven genes (MFSD11, METTL23, CTTNBP2, BACE2, IMPA2, MPPE1 and GNAL) are involved in mental disorders and one gene (MGAT5B) is related to the Golgi complex. Results presented here provide interesting starting points for future research, validation studies and fine mapping of candidate genes involved in bacterial and viral infections in wild boar.

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Section: Discussionmentioning

confidence: 99%

Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy)

Fabbri

Crovetti

Tinacci

et al. 2022

Sci Rep

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show abstract

“…HSV-1 infection is quite prevalent, with 80-90% of the population infected with HSV-1 during their lifetime. After infection, HSV-1 hijacks host cell factors, including miRNAs and lncRNAs, to facilitate viral replication and gene expression (50)(51)(52)(53). A growing body of evidence has revealed that the HSV-1 latency-associated transcript (LAT), a viral lncRNA that is abundantly expressed during latent infection and plays a vital role in the HSV-1 latency reactivation cycle, is an important mediator that promotes viral survival and immune evasion by increasing immune checkpoint expression, thus inducing exhaustion of HSV-1 specific T cells.…”

Section: Herpes Simplex Virus Typementioning

confidence: 99%

Non-coding RNAs: Key players in T cell exhaustion

Wang²

2022

Front. Immunol.

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T cell exhaustion caused by continuous antigen stimulation in chronic viral infections and the tumor microenvironment is a major barrier to successful elimination of viruses and tumor cells. Although immune checkpoint inhibitors should reverse T cell exhaustion, shortcomings, such as off-target effects and single targets, limit their application. Therefore, it is important to identify molecular targets in effector T cells that simultaneously regulate the expression of multiple immune checkpoints. Over the past few years, non-coding RNAs, including microRNAs and long non-coding RNAs, have been shown to participate in the immune response against viral infections and tumors. In this review, we focus on the roles and underlying mechanisms of microRNAs and long non-coding RNAs in the regulation of T cell exhaustion during chronic viral infections and tumorigenesis. We hope that this review will stimulate research to provide more precise and effective immunotherapies against viral infections and tumors.

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“…SRSF1 is not the only member of the SR protein family known to be targeted by miRNAs. SRSF2, a second member of the SR family of proteins, similarly to SRSF1, is also widely expressed and has a diverse role in many biological processes [ 84 ]. This gene is frequently upregulated in many human cancers, and this event is associated with poor prognosis in patients.…”

Section: Rna Splicing Factors Regulated By Mirnasmentioning

confidence: 99%

miRNA-Based Regulation of Alternative RNA Splicing in Metazoans

Schorr¹,

Mangone

2021

IJMS

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Alternative RNA splicing is an important regulatory process used by genes to increase their diversity. This process is mainly executed by specific classes of RNA binding proteins that act in a dosage-dependent manner to include or exclude selected exons in the final transcripts. While these processes are tightly regulated in cells and tissues, little is known on how the dosage of these factors is achieved and maintained. Several recent studies have suggested that alternative RNA splicing may be in part modulated by microRNAs (miRNAs), which are short, non-coding RNAs (~22 nt in length) that inhibit translation of specific mRNA transcripts. As evidenced in tissues and in diseases, such as cancer and neurological disorders, the dysregulation of miRNA pathways disrupts downstream alternative RNA splicing events by altering the dosage of splicing factors involved in RNA splicing. This attractive model suggests that miRNAs can not only influence the dosage of gene expression at the post-transcriptional level but also indirectly interfere in pre-mRNA splicing at the co-transcriptional level. The purpose of this review is to compile and analyze recent studies on miRNAs modulating alternative RNA splicing factors, and how these events contribute to transcript rearrangements in tissue development and disease.

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Splicing factor SRSF2-centric gene regulation

Cited by 27 publications

References 89 publications

Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy)

Identification of candidate genes associated with bacterial and viral infections in wild boars hunted in Tuscany (Italy)

Non-coding RNAs: Key players in T cell exhaustion

miRNA-Based Regulation of Alternative RNA Splicing in Metazoans

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