Split Calvarial Graft to Repair the Large Frontal Bone Defect

Agrawal, Amit; Baisakhiya, Nitish; Bhola, Nitin

doi:10.1007/s12663-010-0048-1

Cited by 11 publications

(3 citation statements)

References 14 publications

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“…Bone reconstruction techniques use either autologous bone (Agrawal et al, 2010) or alloplastic materials (Cabraja et al, 2009;Greene et al, 2008;Staffa et al, 2012). Beyond this choice, a successful cranioplasty requires soft tissue coverage with a tensionfree suture in order to minimize the risk of both implant and bone flap exposure.…”

Section: Introductionmentioning

confidence: 99%

Soft tissue expansion and cranioplasty: For which indications?

Carloni

Hersant

Bosc

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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Section: Introductionmentioning

confidence: 99%

Soft tissue expansion and cranioplasty: For which indications?

Carloni

Hersant

Bosc

et al. 2015

Journal of Cranio-Maxillofacial Surgery

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“…Among which, the most widely used repair materials are titanium and autogenous bone. 7,8 However, titanium presents problems including titanium plate exposure and conductivity. Autologous bone is divided into stored autogenous bone and donor autogenous bone.…”

mentioning

confidence: 99%

“…At present, there are many materials used to repair skull defects, such as autogenous bone, titanium, hydroxyapatite (HA), polyetheretherketone (PEEK), polymethylmethacrylate (PMMA), porous polyethylene, etc. Among which, the most widely used repair materials are titanium and autogenous bone 7,8 . However, titanium presents problems including titanium plate exposure and conductivity.…”

mentioning

confidence: 99%

A New Type of Three-Dimensional Customized Composite Implant in Reconstruction of Large Skull Defects

Huang

Yang

et al. 2020

Journal of Craniofacial Surgery

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Large skull defects can result in chronic injury to intracranial tissues as well as psychological trauma for patients, and their repair presents a challenge to surgeons. Hydroxyapatite has been used in reconstructing skull defects for many years, but it is difficult to adjust the shape and size of the material intraoperatively, especially for large defects. With three-dimensional digital technology, a new type of customized composite implant made of epoxide acrylate maleic and hydroxyapatite has been applied in clinical practice. In this retrospective review, 15 patients with large skull defects (4 female and 11 male, at a mean age of 36.4 years, range from 24-65 years) were treated with the novel customized composite implant, reconstructing the large skull defects successfully. During the average 2.2 years follow-up period (range 0.5-4 years), complications including infection, cerebrospinal fluid leakage, intracranial hemorrhage, or implant exposurea were not occured, only 1 patient (6.7%) with a seroma managed non-operatively. The customized implants, which required no intraoperative adjustments and are about a third of the cost of titanium implants, are an excellent alternative for large skull defect repair.

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Apt‐19s‐Functionalized 3D‐Printed Mesoporous Bioactive Glass Scaffold Promotes BMSC Recruitment in Bone Regeneration via SDF‐1α/CXCR4 Axis and MAPK Signaling

Wang,

Lao,

Huang

et al. 2024

Adv Funct Materials

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Directional migration and differentiation of stem cells in situ are two essential processes for tissue regeneration. However, transplanted scaffold itself lacks sufficient ability to induce stem cell recruitment. As an artificial synthesized nucleic acid, aptamer 19s (Apt‐19s), with high cost‐effectiveness and bioactivity, demonstrates a robust capacity for specific binding and recruitment of mesenchymal stem cells. In this study, a mesoporous bioactive glass scaffold fabricated via a seamless route of self‐assembly and 3D printing (3D‐MBG), functionalized with Apt‐19s is successfully prepared via physical adsorption and lyophilization with optimized release kinetics and bone marrow‐derived mesenchymal stem cells (BMSCs) recruiting efficiency in vitro. This scaffold significantly enhanced migration and osteogenic differentiation of BMSCs in vitro and in vivo. The mechanism underlying Apt‐19s‐induced BMSCs recruitment is elucidated for the first time, that Apt‐19s promoted BMSCs migration by upregulating stromal cell‐derived factor‐1α (SDF‐1α) gene expression, facilitating SDF‐1α protein translation and secretion, and further activating the SDF‐1α/CXCR4 signaling axis and MAPK pathway. In summary, the Apt‐19s‐functionalized 3D‐MBG scaffold offers an economical and efficient solution for customized bone regeneration in situ, and the elucidation of Apt‐19s‐induced BMSCs recruitment at molecular biological level may shed light on its broader clinical applications.

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Split Calvarial Graft to Repair the Large Frontal Bone Defect

Cited by 11 publications

References 14 publications

Soft tissue expansion and cranioplasty: For which indications?

Soft tissue expansion and cranioplasty: For which indications?

A New Type of Three-Dimensional Customized Composite Implant in Reconstruction of Large Skull Defects

Apt‐19s‐Functionalized 3D‐Printed Mesoporous Bioactive Glass Scaffold Promotes BMSC Recruitment in Bone Regeneration via SDF‐1α/CXCR4 Axis and MAPK Signaling

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