Spondylitis and Arthritis in Familial Mediterranean Fever

Sarıkaya, Selda; Özdolap, Şenay; Maraşli, Erdem

doi:10.5606/tjr.2012.043

Cited by 4 publications

(3 citation statements)

References 35 publications

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“…Существует множество публикаций о вовлечении крестцово-подвздошных сочленений при ПБ [11][12][13][14][15][16][17][18]. Р. Langevitz и соавт.…”

Section: Discussionunclassified

“…В этом плане большой интерес представляют серонегативные спондилоартриты (СНСА), так как сакроилеит, являющийся патогномоничным признаком данного заболевания, довольно часто проявляется в качестве составной части суставного синдрома при ПБ. Разными авторами описано поражение крестцово-подвздошного сочленения при ПБ [11][12][13][14][15][16][17][18].…”

Section: Introductionunclassified

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Coexistence of familial Mediterranean fever and seronegative spondyloarthritis: peculiarities of the course

Ginosyan,

Vardanyan,

Eghiazaryan

et al. 2024

Terapevticheskii arkhiv

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Familial Mediterranean fever (FMF) is an autosomal recessive disease distributed among populations of Mediterranean origin – Armenians, Sephardi Jews, Arabs, Turks. There are numerous clinical observations regarding combination of FMF, as a classical representative of autoinflammatory diseases, with systemic diseases of connective tissue. Seronegative spondyloarthritis (SpA) are the most interesting disorders from this point of view, as far as sacroiliitis – an essential feature of SpA, may also present as a part of joint syndrome in FMF. The main objective of this clinical study was the investigation of the peculiarities of courses of FMF and SpA in case of their coexistence. We studied 126 patients with FMF, SpA and coexistence of both. According to results, patients with the overlap of FMF with SpA had relatively milder course of disease in comparison with each disease separately. Comparative clinical and instrumental characteristics of FMF-associated disorders had shown that in FMF-SpA overlap the symptoms of both diseases are less severe.

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Section: Discussionunclassified

Section: Introductionunclassified

Coexistence of familial Mediterranean fever and seronegative spondyloarthritis: peculiarities of the course

Ginosyan,

Vardanyan,

Eghiazaryan

et al. 2024

Terapevticheskii arkhiv

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“…It may be considered a geographic region-specific risk factor for SpA/AS affecting a common inflammatory pathway of IL-1 in the pathogenesis of these diseases. Sarikaya S. et al [22] found that FMF has an earlier onset when compared to other rheumatologic diseases and therefore, in patients with peripheral arthritis and spondylitis, FMF should be considered as differential diagnosis and other signs and symptoms of the disease should be investigated, and an analysis for the MEFV gene might also be helpful in suspicious cases. Moreover recent studies reported the increased innate immune system inflammation seen in FMF may be considered as a susceptibility factor since it predisposes to certain inflammatory conditions and FMF is commonly associated with other inflammatory diseases.…”

Section: Discussionmentioning

confidence: 99%

Joint Manifestations in Children with Familial Mediterranean Fever in Armenia: Clinical and Genetic Characteristics

Amaryan¹,

Khloyan²,

Sarkisian³

et al. 2021

IJI

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Familial Mediterranean fever (FMF) is an autosomal-recessive autoinflammatory disease in the group of Hereditary periodic fever syndromes (HPFS), characterized by recurrent, self-limited attacks of fever and polyserositis, which last 2-4 days. It manifests mainly in childhood and often has early onset, resolve without sequels. Genetic testing of FMF is efficient and allows diagnosing of atypical cases. FMF is a significant health care problem in Armenia because of high frequency of carriers of MEFV mutations 1:3 -4 (0.21) and marked FMF prevalence 54.7 per 10`000 of the total population. Articular symptoms are found in about 45% of cases. They usually manifest as acute recurrent arthritis (ARA) or arthralgia, but more rarely also chronic arthritis can be found. We aimed to investigate clinical and genetic characteristics of the joint manifestations in Armenian children with FMF. The charts of all 715 patients with proven diagnosis of FMF at the National Pediatric Center (NPC) for FMF were reviewed for joint manifestations. The diagnosis of FMF and disease severity were determined according to the Tel-Hashomer criteria and molecular-genetic detection of 12 MEFV mutations common for Armenians. The characteristics of joint manifestations and overall FMF disease were then compared to MEFV mutation analysis. There were 438 boys and 277 girls with an age at diagnosis between 3 months and 17 years (mean age: 8.64±0.17). Joint involvement was observed in 56.4% of all 715 cases. The manifestation was ARA in 30.5%, arthralgia in 21.2% and chronic arthritis (CA) in 4.7%, which would also qualify for a diagnosis of JIA. The frequency of ARA was associated with M694V mutation, mainly M694V homozygous and M694V heterozygous genotypes. The risk of CA depended on MEFV genotype of the FMF patients and was the highest in M694Vheterozygotes and M694Vhomozygotes. M694V heterozygous genotype was noticed significantly more frequently among FMF patients with spondyloarthritis in comparison to those without it. The probability of the development of CA among FMF patients without M694V mutation was significantly higher also in heterozygotes in comparison to compound-heterozygotes. We concluded, that the frequency of joint involvement among Armenian pediatric FMF patients was high -56.4%, especially for CA. Chronic arthritis may be the first manifestation of FMF and occurred usually in patients with severe M694V mutations. Patients of Armenian origin with refractory arthritis should be asked for isolated febrile attacks, hemorrhagic vasculitis, episodes of pleuritis and family history to rule out FMF.

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Recurrent Episodes of Fever and Arthritis in an Adult Patient

Cobilinschi¹,

Belinski²,

Predeţeanu³

et al. 2017

Ro J Rheumatol.

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Familial Mediterranean Fever (FMF) is the most common condition in the group of autoinflammatory diseases. It has a relatively heterogeneous clinical display included in the Tel-Hashomer diagnostic criteria that can be further confirmed by genetic testing showing a mutation in the MEFV gene. AA Amyloidosis is the most sever complication in these patients. Colchicine is the standard treatment and/or alternative biological agents if necessary. This article aims to describe the evolution of a patient with FMF, firstly diagnosed as reactive arthritis, his clinical manifestations and therapeutic options.

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Spondylitis and Arthritis in Familial Mediterranean Fever

Cited by 4 publications

References 35 publications

Coexistence of familial Mediterranean fever and seronegative spondyloarthritis: peculiarities of the course

Coexistence of familial Mediterranean fever and seronegative spondyloarthritis: peculiarities of the course

Joint Manifestations in Children with Familial Mediterranean Fever in Armenia: Clinical and Genetic Characteristics

Recurrent Episodes of Fever and Arthritis in an Adult Patient

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