Spondyloarthropathies in sub-Saharan Africa

Mijiyawa, M; Oniankitan, Owonayo; Khan, Muhammad Asim

doi:10.1097/00002281-200007000-00008

Cited by 96 publications

(54 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Wu et al [9] reported prevalence of HLA-B27 in patients with SNSAs about 40%, Buschiazzo et al reported 45% without sexual separation [10]. Mijiyawa et al reported positive HLA-B27 in of African patients with SNSAs [11]. They reminded that HLA-B27 is not a suitable marker to diagnose these diseases in Africans while others consider the relation between HLA-B27 and serongative spondyloarthropathies as an obvious example of relation between a group of diseases and a special heritage marker [11].…”

Section: Discussionmentioning

confidence: 99%

A Survey on the Frequency of HLA-B27 in Patients Engaged With Seronegative Spondyloarthropathies in Kashan, Iran

Esalatmanesh

Taghadosi

Arj

2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

Background: Seronegative Spondyloarthropathies (SNSAs) are referred to a group of diseases with same clinical and genetic features. Objectives: Due to lack of data about HLA-B27 prevalence in patient with SNSA in Kashan this study was conducted to determine the status of HLA-B27 in these patients. Patients and Methods:This cross sectional study was conducted on 294 patients suffered from SNSA. Presence or absence of HLA-B27 was checked by serological method using Greener kit. Results were analyzed with SPSS-16 software using t-test and χ 2 test. Results: Of all 26.5% of subjects were HLA-B27 positive. HLA-B27 was significantly more frequent in male patients (34.1% vs. 16.5%, P < 0.001). Prevalence of HLA-B27 was 69% in ankylosing spondylitis, 31.5% in psoriatic arthritis, 18.2% in entropathic arthropathy, 17.9% in undifferentiated spondyloarthropathies, 16.1% in reactive arthritis and 12.5% in juvenile rheumatoid arthritis (P < 0.001). Conclusions: HLA-B27 has highest prevalence in ankylosing spondylitis and least prevalence in juvenile rheumatoid arthritis. HLA-B27 prevalence was in relation with gender, type of disease, family history, peripheral, and axial joints engagement.

show abstract

Section: Discussionmentioning

confidence: 99%

A Survey on the Frequency of HLA-B27 in Patients Engaged With Seronegative Spondyloarthropathies in Kashan, Iran

Esalatmanesh

Taghadosi

Arj

2015

Zahedan J Res Med Sci

View full text Add to dashboard Cite

show abstract

“…This decrease is probably related to a decline in the rate of sexually transmitted disease secondary to the awareness of human immunodeficiency virus (HIV) infection. In contrast, in South Africa, where ReA used to be extremely rare and where HLA-B27 has a prevalence of less than 1%, the prevalence of ReA is now increasing in the wake of the HIV epidemic (98,142,223).…”

Section: Epidemiologymentioning

confidence: 99%

HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

2004

View full text Add to dashboard Cite

Current evidence supports the concept that reactive arthritis (ReA) is an immune-mediated synovitis resulting from slow bacterial infections and showing intra-articular persistence of viable, nonculturable bacteria and/or immunogenetic bacterial antigens synthesized by metabolically active bacteria residing in the joint and/or elsewhere in the body. The mechanisms that lead to the development of ReA are complex and basically involve an interaction between an arthritogenic agent and a predisposed host. The way in which a host accommodates to invasive facultative intracellular bacteria is the key to the development of ReA. The details of the molecular pathways that explain the articular and extra-articular manifestations of the disease are still under investigation. Several studies have been done to gain a better understanding of the pathogenesis of ReA; these constitute the basis for a more rational therapeutic approach to this disease

show abstract

“…In sub-Saharan Africa, AS is also very uncommon (27). Thus, the finding that 4 of 8 unrelated Togolese patients with AS, an exceptionally large series for an African population, carried B*1403 constituted strong evidence of the association of this allele with AS (23).…”

mentioning

confidence: 98%

Disparate folding and stability of the ankylosing spondylitis–associated HLA–B1403 and B2705 proteins

Merino¹,

Galocha²,

Vázquez³

et al. 2008

Arthritis & Rheumatism

View full text Add to dashboard Cite

Objective. To investigate the folding, assembly, maturation, and stability of HLA-B*1402 and B*1403, which differ by 1 amino acid change and are differentially associated with ankylosing spondylitis (AS), and to compare these features with those of B*2705.Methods. Stable transfectants expressing B*1402, B*1403, and B*2705 were used. Folding rates were estimated from the ratio of unfolded heavy chains to folded heavy chains that had been immunoprecipitated with specific antibodies in pulse-chase experiments. Heavy chain misfolding was measured as the half-life of endoglycosidase H (Endo H)-sensitive ␤ 2 -microglobulinfree heavy chains. Maturation/export rates were measured by acquisition of Endo H resistance. Association with calnexin or tapasin was analyzed by coprecipitation with chaperone-specific antibodies, and surface expression was estimated by flow cytometry. Thermostability of HLA-peptide complexes was assessed by immunoprecipitation after incubation at various temperatures. Heavy chain expression was quantified by Western blotting.Results. The folding rates of B*1402 and B*1403 were similar, and both were faster and more efficient than B*2705, but some unfolded heavy chains from both B14 subtypes remained in the endoplasmic reticulum (ER) with a long half-life. The export rates of B*1402 and B*1403 were slow, and the heterodimers partially dissociated after exiting the ER, as revealed by significant amounts of Endo H-resistant and surface-expressed free heavy chains. Both interaction with tapasin and thermostability were higher for B*2705 than for B*1402 and higher for B*1402 than for B*1403, suggesting that the repertoires of the B*1402-bound peptide and especially the B*1403-bound peptide were less optimized than that of B*2705.Conclusion. Our results indicate that the folding, maturation, and stability of B*1403 differ more from B*2705 than from B*1402. Thus, these features cannot account for the fact that only the 2 former allotypes are associated with AS.

show abstract

Spondyloarthropathies in sub-Saharan Africa

Cited by 96 publications

References 29 publications

A Survey on the Frequency of HLA-B27 in Patients Engaged With Seronegative Spondyloarthropathies in Kashan, Iran

A Survey on the Frequency of HLA-B27 in Patients Engaged With Seronegative Spondyloarthropathies in Kashan, Iran

HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

Disparate folding and stability of the ankylosing spondylitis–associated HLA–B1403 and B2705 proteins

Contact Info

Product

Resources

About

Spondyloarthropathies in sub-Saharan Africa

Cited by 96 publications

References 29 publications

A Survey on the Frequency of HLA-B27 in Patients Engaged With Seronegative Spondyloarthropathies in Kashan, Iran

A Survey on the Frequency of HLA-B27 in Patients Engaged With Seronegative Spondyloarthropathies in Kashan, Iran

HLA-B27-Associated Reactive Arthritis: Pathogenetic and Clinical Considerations

Disparate folding and stability of the ankylosing spondylitis–associated HLA–B*1403 and B*2705 proteins

Contact Info

Product

Resources

About

Disparate folding and stability of the ankylosing spondylitis–associated HLA–B1403 and B2705 proteins