Sponges: A Reservoir for Microorganism‐Derived Bioactive Metabolites

Amarendra, Visamsetti; Santhosh, Ramachandran Sarojini; Dhevendaran, K.

doi:10.1002/9783527665259.ch24

Cited by 4 publications

(2 citation statements)

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“…We found that the genera identified belong to three phyla (Firmicutes, Actinobacteria and Proteobacteria). The genera Bacillus , Fictibacillus , Streptomyces , Micromonospora and Pseudoalteromonas have been frequently isolated from marine and deep‐sea sediments and are widely known for produce bioactive metabolites (Amarendra et al, 2013; Chen et al, 2019; Velásquez et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

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In vitro biological activity of extracts from marine bacteria cultures against Toxoplasma gondii and Mycobacterium tuberculosis

Quintero

Blandón

Vidal

et al. 2022

Journal of Applied Microbiology

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Aims:To evaluate the biological activity of extracts from cultures of marine bacteria against Toxoplasma gondii and Mycobacterium tuberculosis. Methods and Results: Ethyl acetate extracts obtained from seven marine bacteria were tested against T. gondii GFP-RH and M. tuberculosis H37Rv. The cytotoxicity on HFF-1 cells was measured by a microplate resazurin fluorescent approach, and the haemolytic activity was determined photometrically. The extracts from Bacillus sp. (INV FIR35 and INV FIR48) affected the tachyzoite viability. The extracts from Bacillus, Pseudoalteromonas, Streptomyces and Micromonospora exhibited effects on infection and proliferation processes of parasite. Bacillus sp. INV FIR48 extract showed an minimum inhibitory concentration value of 50 µg ml −1 against M. tuberculosis H37Rv. All the extracts exhibited relatively low toxicity to HFF-1 cells and the primary culture of erythrocytes, except Bacillus sp. INV FIR35, which decreased cell viability under 20%. Liquid chromatography coupled to mass spectrometry analysis of the most active bacterial extract Bacillus sp. INV FIR48 showed the presence of peptide metabolites related to surfactin. Conclusions: The extract from culture of deep-sea Bacillus sp. INV FIR48 showed anti-T. gondii and anti-tuberculosis (TB) biological activity with low cytotoxicity. In addition, peptide metabolites were detected in the extract. Significance and Impact of the Study: Toxoplasmosis and TB are among the most prevalent diseases worldwide, and the current treatment drugs exhibit side effects.This study confirm that marine bacteria are on hand sources of anti-infective natural products.

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Section: Discussionmentioning

confidence: 99%

“…have been frequently isolated from marine and deep-sea sediments and are widely known for produce bioactive metabolites (Amarendra et al, 2013;Chen et al, 2019;Velásquez et al, 2018).…”

Section: Discussionmentioning

confidence: 99%