Spongy film of cellulosic polysaccharide as a dressing for aphthous stomatitis treatment in rabbits

Abstract

PURPOSE:To develop an experimental model of acute inflammation, like aphthous ulcers, in oral cavity of rabbits, and also, to evaluate the results of the application of a polysaccharide spongy film of molasses from sugar cane as assist treatment in the healing process. METHODS:Twenty adult rabbits weighting between 2.5 kg and 3.9 kg were divided into two groups: experimental and control infected ulcers were induced on the jugal mucosa by surgical excision. They were treated at the experimental group by curettage and dressing with spongy film of cellulosic polysaccharide film, whereas saline solution was used in the control group. Temporal evolution of the healing area, histopathology and bacteriological analysis were used to evaluate the healing process on the 3 rd (D3), 7 th (D7) and 11 th days (D11). RESULTS:The healing time and bacteriological study showed no statistical differences on the group means. Analyzing the histopathology of the experimental group we verified epithelial hyperplasia from D3 to D11, instead in the control group there was a greater clutter of the epithelial cells from the D3 to D11. CONCLUSION:The experimental model used caused aphthous ulcers and the polysaccharide sponge film can be used as an aid in the symptomatic treatment and healing of the ulcerative lesions of the oral mucosa.

A wet dressing for male genital surgery: A phase II clinical trial

“…BC is a biomaterial, obtained by bacterial synthesis from sugarcane molasses (13), described in previous studies as a safe dressing with low toxicity (14), biocompatible (15), promoting growth and cell differentiation (17) and, thus, contributing to the healing process (9, 16, 17) and epithelialization (18). Preclinical and clinical studies have shown that this biomaterial is effective as a mechanical barrier and adjuvant in the treatment of surgical wounds (9) and in ulcerative injuries (17).…”

“…Preclinical and clinical studies have shown that this biomaterial is effective as a mechanical barrier and adjuvant in the treatment of surgical wounds (9) and in ulcerative injuries (17). …”

O Potencial Limitante Da Hipertrofia Mamária Na Adolescência: Um Estudo De Revisão Sistematizado

“…É formado de açúcares polimerizados estáveis. Devido à sua composição química e características físicas, a CB é um biomaterial próspero para muitos usos médicos e biológicos (TEIXEIRA et al, 2014).…”

“…Diversos estudos, envolvendo análises experimentais e testes clínicos evidenciaram que a CB não é tóxica, é biocompatível e é eficiente para o remodelamento tecidual (FRAGOSO et al, 2014;PINTO et al, 2016;. O biopolímero celulósico em condição de pureza expressa elasticidade, resistência à tração, flexibilidade e ainda pode ser moldado em diferentes formas, características físico-químicas básicas para a síntese de implantes biológicos (TEIXEIRA et al, 2014).…”

Unha cirúrgica de biopolímero de cana de açúcar para preservação do leito ungueal após avulsão

“…Estudos anteriores mostram que um exopolissacarídeo celulósico obtido a partir do melaço da cana de açúcar, pela síntese de bactérias Gram negativas do gênero Zoogloea pertencentes à família Pseudomonadaceae, proporcionou uma adequada cicatrização às feridas cutâneas em animais, otimizando o tempo de cicatrização e promovendo o controle de infecção (8) . Outros estudos (9)(10)(11) mostram que o biopolímero de cana de açúcar (BPCA) foi eficiente como barreira mecânica e adjunto no tratamento de lesões ulceradas.…”