Spontaneous Abortions Among Finnish Flight Attendants

Aspholm, Rafael; Lindbohm, Marja-Liisa; Paakkulainen, Harri; Taskinen, Helena; Nurminen, Tuula; Tiitinen, Aila

doi:10.1097/00043764-199906000-00015

Cited by 51 publications

(30 citation statements)

References 11 publications

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“…Self-reported data on spontaneous abortion at low gestational ages are often subject to bias and are difficult to interpret, particularly if obtained in studies with low participation rates. On the other hand, a register-based Finnish cohort study found a slightly elevated risk of spontaneous abortion (18).…”

Section: Discussionmentioning

confidence: 94%

Pregnancy outcome among offspring of airline pilots and cabin attendants

Irgens¹,

Irgens²,

Reitan³

et al. 2003

Scand J Work Environ Health

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Objectives This study assessed the occurrence of perinatal death, low birthweight, preterm birth, and birth defects (total, major, neural tube defects, total cleft, cleft palate, hypospadias, and Down syndrome) in the offspring of airline pilots and cabin attendants.Methods A cohort of offspring of airline pilots and cabin attendants was established and characterized in terms of parental exposure to cosmic radiation the year before birth or ever. Pregnancy outcome was derived from the Medical Birth Register of Norway. The reference group comprised offspring of parents without occupational exposure to cosmic radiation. ResultsNo deviant risks were observed for the offspring of male pilots, either for the year preceding birth (N=2111) or ever (N=2356). Specific birth outcomes were fewer for the pilots than for the referents (N=1 621 186), except for Down syndrome, which was more frequent [odds ratio (OR) 1.41, 95% confidence interval (95% CI) 0.53-3.76]. For exposure the year preceding birth (N=2512), the risk of low birthweight was lower for the female cabin attendants than for the referents (adjusted OR 0.83, 95% CI 0.69-1.00), while Down syndrome was more frequent (OR 1.44, 95% CI 0.60-3.47). For exposure ever (N=3346), the risk of low birthweight was lower (OR 0.82, 95% CI 0.70-0.96) for the cabin attendants, while hypospadias (OR 1.18, 95% CI 0.61-3.04) and Down syndrome (OR 1.79, 95% CI 0.03-3.45) were more frequent. ConclusionsIn general, offspring of air pilots and cabin attendants do not seem to be at increased risk of adverse pregnancy outcome.

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Section: Discussionmentioning

confidence: 94%

Pregnancy outcome among offspring of airline pilots and cabin attendants

Irgens¹,

Irgens²,

Reitan³

et al. 2003

Scand J Work Environ Health

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“…Pregnancy outcome may also be compromised by circadian disruption, as shift work and frequent travel across time zones have been associated with reduced fertility and poor pregnancy outcome (95,96). Pregnant women on rotating shifts have greater risk of preterm births and lowbirth-weight infants (97).…”

Section: Reproductive Systemmentioning

confidence: 99%

Endocrine Effects of Circadian Disruption

Bedrosian

Fonken

Nelson

2016

Annu. Rev. Physiol.

118

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Disruption of circadian rhythms, provoked by artificial lighting at night, inconsistent sleep-wake schedules, and transmeridian air travel, is increasingly prevalent in modern society. Desynchrony of biological rhythms from environmental light cycles has dramatic consequences for human health. In particular, disrupting homeostatic oscillations in endocrine tissues and the hormones that these tissues regulate can have cascading effects on physiology and behavior. Accumulating evidence suggests that chronic disruption of circadian organization of endocrine function may lead to metabolic, reproductive, sleep, and mood disorders. This review discusses circadian control of endocrine systems and the consequences of distorting rhythmicity of these systems.

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“…High-LET radiation is effective at directly breaking DNA strands in biological tissue, or producing chemically active radicals in tissue that alter the cell function, both of which can lead to cancer or other adverse health effects (Wilson et al, 2003;. Studies of flight attendants have suggested adverse reproductive health outcomes (Aspholm et al, 1999;Lauria et al, 2006;Waters et al, 2000). The International Commission on Radiological Protection (ICRP) classify crews of commercial aircraft as radiation workers (ICRP, 1991).…”

Section: Introductionmentioning

confidence: 99%