Spontaneous and In Vitro Induced Apoptosis of Lymphocytes and Neutrophils in Patients with Alcohol Dependence

Abstract

Spontaneous and induced apoptosis of neutrophils and lymphocytes was studied in alcoholics during the abstinent syndrome and in healthy individuals. In alcoholics, the levels of lymphocyte and neutrophil apoptosis at the receptor and cellular levels were higher than in healthy subjects. Blood cells from alcohol addicts and normal individuals similarly react to stimuli (hyperthermia and synthetic glucocorticoid prednisolone) in vitro.

Use of Carnosine for Oxidative Stress Reduction in Different Pathologies

“…It has been reported that in alcoholic patients oxidative stress contributes strongly to forming somatic complications [ 64 ], disturbance of immune status [ 65 ], and induction of apoptosis [ 66 ]. In alcoholism, formation of OS can be increased by ethanol, the concentration of which significantly exceeds the norm in patients, as well as the toxic metabolite of ethanol-acetaldehyde, whose level also increases in the organism during alcoholic intoxication.…”

Neuroprotective Effects of Cortexin on Oxidattive Stress- And Ethanol-Induced Apoptosis of C-1300 Neuroblastoma Cell Line

“…Полученные данные о нарушениях процессов запрограммированной клеточной гибели, в частности об изменениях уровня внутриклеточных регуляторных белков в условиях окислительного стресса и под воздействием этанола согласуются с литературными данными[11]. Tejedo J. C. с соавторами[12] показали токсическое воздействие оксида азота на клетки RINm5F, в результате которого происходит индукция апоптотических событий, таких как выделение цитохрома С из митохондрий, регуляция внутриклеточного белка Bcl-2, активация каспазы 3, фрагментация ДНК.…”