Spontaneous cutaneous umbilical endometriosis: Report of a new case with immunohistochemical study and literature review

Kyamidis, Kyriakos; Lora, Viviana; Kanitakis, Jean

doi:10.5070/d33mj2444n

Cited by 58 publications

(24 citation statements)

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“…Umbilical endometriosis (UE), or Villar's nodule, as first described by Villar in 1886, is defined as the presence of endometrial glands and/or stroma within the umbilicus. It is a rare form of endometriosis with a frequency of around 0.4-4% of extragenital lesions [8,9] and around 0.5-1% of all cases of endometriosis [10][11][12], and it has been reported that it represents 30-40% of cases of abdominal wall endometriosis (AWE) [13]. Generally, UE presents with a red, purple, or black umbilical nodule with a diameter ranging from 0.5 to 3 cm [14].…”

Section: Introductionmentioning

confidence: 99%

Umbilical Endometriosis: A Systematic Literature Review and Pathogenic Theory Proposal

Dridi

Chiaffarino

Parazzini

et al. 2022

JCM

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Umbilical endometriosis represents 30–40% of abdominal wall endometriosis and around 0.5–1.0% of all cases of endometriosis. The aim of this systematic review is to revisit the epidemiology, signs, and symptoms and to formulate a pathogenic theory based on literature data. We performed a systematic literature review using the PubMed and Embase databases from 1 January 1950 to 7 February 2021, according to the PRISMA guidelines. The review was registered at PROSPERO (CRD42021239670). Studies were selected if they reported original data on umbilical endometriosis nodule defined at histopathological examination and described as the presence of endometrial glands and/or stromal cells in the connective tissue. A total of 11 studies (10 retrospective and one prospective), and 14 case series were included in the present review. Overall, 232 umbilical endometriosis cases were reported, with the number per study ranging from 1 to 96. Umbilical endometriosis was observed in 76 (20.9%; 95% CI 17.1–25.4) of the women included in studies reporting information on the total number of cases of abdominal wall endometriosis. Umbilical endometriosis was considered a primary form in 68.4% (158/231, 95% CI 62.1–74.1) of cases. A history of endometriosis and previous abdominal surgery were reported in 37.9% (25/66, 95% CI 27.2–49.9) and 31.0% (72/232, 95% CI 25.4–37.3) of cases, respectively. Pain was described in 83% of the women (137/165, 95% CI 76.6–88.0), followed by catamenial symptoms in 83.5% (142/170, 95% CI, 77.2–88.4) and bleeding in 50.9% (89/175, 95% CI 43.5–58.2). In the 148 women followed for a period ranging from three to 92.5 months, seven (4.7%, 95% CI 2.3–9.4) recurrences were observed. The results of this analysis show that umbilical endometriosis represents about 20% of all the abdominal wall endometriotic lesions and that over two thirds of cases are primary umbilical endometriosis forms. Pain and catamenial symptoms are the most common complaints that suggest the diagnosis. Primary umbilical endometriosis may originate from implantation of regurgitated endometrial cells conveyed by the clockwise peritoneal circulation up to the right hemidiaphragm and funneled toward the umbilicus by the falciform and round liver ligaments.

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Section: Introductionmentioning

confidence: 99%

Umbilical Endometriosis: A Systematic Literature Review and Pathogenic Theory Proposal

Dridi

Chiaffarino

Parazzini

et al. 2022

JCM

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“…Endometriosis is defined as the presence of endometrial like tissue outside the uterus [1] . It is a complex symptomatic, pathobiological, multisystemic disease that affects women from menarche through menopause regardless of ethnic origin or social status [2] , [3] . Being a chronic recurrent disease it affects the quality of life of patients significantly.…”

Section: Introductionmentioning

confidence: 99%

Primary Umbilical endometriosis - case series and review of clinical presentation, diagnosis and management

Bindra

Sampurna

Kade³

et al. 2022

International Journal of Surgery Case Reports

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“…They have been classified into three main categories, i.e., the embryonic rest theory, the coelomic metaplasia theory, and the migratory pathogenesis theory [4,7]. The embryonic rest theory explains the pelvic endometriosis such as a stimulus to a Müllerian origin cell nest [4,[9][10][11]. The migratory pathogenesis by implantation or retrograde menstruation theory explains the implantation on surrounding pelvic structures [4,[9][10][11].…”

Section: Discussionmentioning

confidence: 99%

“…The embryonic rest theory explains the pelvic endometriosis such as a stimulus to a Müllerian origin cell nest [4,[9][10][11]. The migratory pathogenesis by implantation or retrograde menstruation theory explains the implantation on surrounding pelvic structures [4,[9][10][11]. Direct transplantation can explain the endometriosis occurring on surgical scars, but does not explain the distant locations, therefore Halban advocated the dissemination theory of vascular migration through vascular or lymphatic channels and in also surgical procedures [5,9].…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, surgical resection of an umbilical endometrioma with safety and clear margins is the treatment of choice, and offers the highest probability of both a definitive diagnosis and a favorable outcome. Preservation of the umbilicus is preferred, but if the umbilicus has to be completely removed in order to achieve radical excision, certain methods can provide adequate reconstruction [11].…”

Section: Discussionmentioning

confidence: 99%

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Spontaneous cutaneous umbilical endometriosis: a rare variant of extragenital endometriosis

N’guessan¹,

N'guessan²,

Mian³

et al. 2014

Clin. Exp. Obstet. Gynecol.

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Umbilical endometriosis is a very uncommon condition which presents as a pigmented umbilical nodule, papular or cystic, with symptoms punctuated rhythmed by menses. The authors report the case of a 32-year-old with spontaneous umbilical endometriosis. Surgical resection was performed with a good cosmetic result and no recurrence at six months. A review of the literature allowed the authors to discuss the diagnosis difficulties and treatment in a underdeveloped country.

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Spontaneous cutaneous umbilical endometriosis: Report of a new case with immunohistochemical study and literature review

Cited by 58 publications

References 0 publications

Umbilical Endometriosis: A Systematic Literature Review and Pathogenic Theory Proposal

Umbilical Endometriosis: A Systematic Literature Review and Pathogenic Theory Proposal

Primary Umbilical endometriosis - case series and review of clinical presentation, diagnosis and management

Spontaneous cutaneous umbilical endometriosis: a rare variant of extragenital endometriosis

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