Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 Mouse

Yasui, Yuzo; Ohta, Yasusada; Ueda, Yoshihide; Hasegawa, Kazushige; Kihara, Tohru; Hosoi, Masayo; Miyajima, Rumiko; Shiga, Atsushi; Imai, Kiyoshi; Toyoda, Kazuhiro

doi:10.1177/0192623309333786

Cited by 6 publications

(3 citation statements)

References 13 publications

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“…Furthermore, there were single cases described in the pituitary gland of an SD-derived rat (Pace and Perentes 2001) and an aged F344 rat (Okazaki et al 1997). Ganglioneuroma also may occur as a spontaneous neoplasm in hamsters (Rustia and Cardesa 1975) and has been shown to arise from the trigeminal ganglion in an aged B6C3F1 mouse (Yasui et al 2009). The malignant form of ganglioneuroma is the ganglioneuroblastoma, a neuroblastoma variant characterized by a small region of dark basophilic, oval, stemlike cells surrounded by ganglion cells.…”

Section: Ganglioneuroma and Ganglioneuroblastomamentioning

confidence: 99%

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

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Neoplasms of the nervous system, whether spontaneous or induced, are infrequent in laboratory rodents and very rare in other laboratory animal species. The morphology of neural tumors depends on the intrinsic functions and properties of the cell type, the interactions between the neoplasm and surrounding normal tissue, and regressive changes. The incidence of neural neoplasms varies with sex, location, and age of tumor onset. Although the onset of spontaneous tumor development cannot be established in routine oncogenicity studies, calculations using the time of diagnosis (day of death) have revealed significant differences in tumor biology among different rat strains. In the central nervous system, granular cell tumors (a meningioma variant), followed by glial tumors, are the most common neoplasms in rats, whereas glial cell tumors are observed most frequently in mice. Central nervous system tumors usually affect the brain rather than the spinal cord. Other than adrenal gland pheochromocytomas, the most common neoplasms of the peripheral nervous system are schwannomas. Neural tumors may develop in the central nervous system and peripheral nervous system from other cell lineages (including extraneural elements like adipose tissue and lymphocytes), but such lesions are very rare in laboratory animals.

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Section: Ganglioneuroma and Ganglioneuroblastomamentioning

confidence: 99%

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Weber¹,

Garman²,

Germann³

et al. 2010

Toxicol Pathol

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“…[ 15 ] Immunohistochemical staining for S100, neurofilaments, chromogranin, NSE, CD34, and synaptophysin was positive in ganglion cells and nerve sheath cells. [ 16 – 21 ] S100, synaptophysin, neurofilaments were positive in neuroblastoma cells. [ 22 , 23 ] In the study, histopathology showed the positive staining of CD34, calretinin, GFAP, Ki-67, SOX-10, and SYN in gangliocellular area (Fig.…”

Section: Discussionmentioning

confidence: 99%

Adult hippocampal ganglioneuroblastoma

Yao

Chen²,

Shang-Guan³

et al. 2017

Medicine

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Rationale:Intracranial ganglioneuroblastoma represents a rare subtype of primitive neuroectodermal tumor. Here, we report a hippocampal ganglioneuroblastoma and a literature review of cerebral anglioneuroblastoma is carried out.Patient concerns:We report a 16-year-old male patient presenting with absence seizure and high-infiltration hippocampal ganglioneuroblastoma.Interventions:Magnetic resonance imaging (MRI) indicates a space-occupying lesion with a well-defined margin in the right temporal lobe and hippocampus. However, hyper-signal on flair and diffusion-weighted imaging (DWI) with a low apparent diffusion coefficient (ADC) value is detected, which prompts high tumoral invasiveness.Interventions:A total resection of tumor and subsequent chemotherapy combing with radiotherapy is performed.Outcomes:For a follow-up period of 60 months, no evidence of recurrence and further seizures are detected.Lessons:High-infiltration hippocampal ganglioneuroblastoma is a rare event. MRI examination often showed features of low-grade gliomas, while hyper-signal lesion on DWI with a low ADC value can be detected. Complete resection combined with fractionated radiotherapy and chemotherapy was the optimal treatment for cerebral ganglioneuroblastoma.

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“…Keratin AE1/AE3, SMA, and melan-A were all negative, suggesting against a spindled carcinoma, melanoma, and leiomyomatous proliferation. GFAP was negative, as sometimes can be seen in Schwann cells and ganglion cells [ 11 ].…”

Section: Case Presentationmentioning

confidence: 99%

Diffuse Gastric Ganglioneuromatosis: Novel Presentation ofPTENHamartoma Syndrome—Case Report and Review of Gastric Ganglioneuromatous Proliferations and a NovelPTENGene Mutation

Williams

Doherty

Hart

et al. 2018

Case Reports in Medicine

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Gastrointestinal ganglioneuromatous proliferations are rare, most often found in the colon, and are three types: polypoid ganglioneuromas, ganglioneuromatous polyposis, and diffuse ganglioneuromatosis. We present a case of diffuse ganglioneuromatosis in the posterior gastric wall in a nine-year-old female. To our knowledge, this is the first reported case of diffuse ganglioneuromatosis located in the stomach. Only six cases of gastric ganglioneuromatous proliferations have previously been reported, two in English and none were diffuse ganglioneuromatosis. A diagnosis of diffuse ganglioneuromatosis is relevant for patient care because, unlike sporadic polypoid ganglioneuromas or ganglioneuromatous polyposis, most are syndromic. Diffuse ganglioneuromatosis is commonly associated with neurofibromatosis type 1, multiple endocrine neoplasia type 2b, and Cowden Syndrome, one of the phenotypes of PTEN hamartoma tumor syndrome. The patient had the noted gastric diffuse ganglioneuromatosis, as well as other major and minor criteria for Cowden syndrome. Genetic testing revealed a novel frameshift mutation in the PTEN gene in the patient, her father, paternal aunt, and the aunt's son who is a paternal first cousin of the patient.

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Spontaneous Ganglioneuroma Possibly Originating from the Trigeminal Ganglion in a B6C3F1 Mouse

Cited by 6 publications

References 13 publications

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Classification of Neural Tumors in Laboratory Rodents, Emphasizing the Rat

Adult hippocampal ganglioneuroblastoma

Diffuse Gastric Ganglioneuromatosis: Novel Presentation ofPTENHamartoma Syndrome—Case Report and Review of Gastric Ganglioneuromatous Proliferations and a NovelPTENGene Mutation

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