Spontaneous Generation of Carbon Monoxide Within Anesthetic Circuits

Moon, Re; Ingram, Charles T.; Brunner, E A; Meyer, Andrew F.

doi:10.1097/00000542-199109001-00872

Cited by 27 publications

(15 citation statements)

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“…On the other hands, isoflurane has also been reported to be hepatotoxic, cytotoxic and genotoxic compounds in humans (Kenna and Jones, 1972;Kvolik et al, 2005;Anders, 2005). Moreover, it has been reported that patients anesthetized with isoflurane or enflurane have elevated blood carboxyhemoglobin levels, which may induce cytotoxicities (Moon et al, 1991).…”

Section: Discussionmentioning

confidence: 99%

Oxidative damages in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols

Kim

et al. 2006

Toxicology

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Section: Discussionmentioning

confidence: 99%

Oxidative damages in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols

Kim

et al. 2006

Toxicology

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“…This clinical observation received minimal attention until 1990, when it became evident that inhalational anesthetics could form carbon monoxide within the anesthesia machine (203,204). A common finding in these reports was that carbon monoxide accumulation occurred during the first surgical case on Monday mornings.…”

Section: Carbon Monoxidementioning

confidence: 99%

Sevoflurane: Approaching the Ideal Inhalational Anesthetic A Pharmacologic, Pharmacoeconomic, and Clinical Review

2001

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Sevoflurane is a safe and versatile inhalational anesthetic compared with currently available agents. Sevoflurane is useful in adults and children for both induction and maintenance of anesthesia in inpatient and outpatient surgery. Of all currently used anesthetics, the physical, pharmacodynamic, and pharmacokinetic properties of sevoflurane come closest to that of the ideal anesthetic (200). These characteristics include inherent stability, low flammability, non-pungent odor, lack of irritation to airway passages, low blood:gas solubility allowing rapid induction of and emergence from anesthesia, minimal cardiovascular and respiratory side effects, minimal end-organ effects, minimal effect on cerebral blood flow, low reactivity with other drugs, and a vapor pressure and boiling point that enables delivery using standard vaporization techniques. As a result, sevoflurane has become one of the most widely used agents in its class.

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“…However, there are reports of severe CO intoxications [2,3] recently published by Berry et al [14] with desflurane as anesthetic agent. The highest risk develops when fresh gas flow is maintained in a anesthesia system for a few days.…”

Section: Discussionmentioning

confidence: 99%

Carbon monoxide production from five volatile anesthetics in dry sodalime in a patient model: halothane and sevoflurane do produce carbon monoxide; temperature is a poor predictor of carbon monoxide production

2005

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Spontaneous Generation of Carbon Monoxide Within Anesthetic Circuits

Cited by 27 publications

References 0 publications

Oxidative damages in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols

Oxidative damages in the DNA, lipids, and proteins of rats exposed to isofluranes and alcohols

Sevoflurane: Approaching the Ideal Inhalational Anesthetic A Pharmacologic, Pharmacoeconomic, and Clinical Review

Carbon monoxide production from five volatile anesthetics in dry sodalime in a patient model: halothane and sevoflurane do produce carbon monoxide; temperature is a poor predictor of carbon monoxide production

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