Spontaneous Hypoglycemia Associated with Congestive Heart Failure Attributable to Hyperinsulinism

Khoury, H. Jean; Daugherty, Tim; Ehsanipoor, Kaveh

doi:10.4158/ep.4.2.94

Cited by 6 publications

(3 citation statements)

References 4 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Geometric mean parasite densities (GMPD) [95% reference range], median Hb levels (range) and mean body temperature (± standard deviation) in children with severe as compared to mild malaria, were 34,754/µl [24,,820] vs. 39,174/µl [33,325] (P = 0.08), 4.9 g/dl (1.5-13.4) vs. 7.5 g/dl (5.0-11.7) (P < 0.0001), and 38.6 ± 1.1°C vs. 38.7 ± 0.8°C (P = 0.09), respectively. The median age and (range) of the 400 children (200 girls and 200 boys) was 24 months (6-102).…”

Section: Resultsmentioning

confidence: 99%

“…Acidosis and hypoglycemia tend to occur concurrently [28] and acidosis affects gluconeogenesis. Both metabolic conditions may impair myocardial integrity and function [29][30][31][32][33][34][35] and are manifestations of multiple organ failure [36]. At this stage, patients with severe malaria and sepsis exhibit very similar metabolic conditions [36,37] and are clinically almost indistinguishable [38].…”

Section: Discussionmentioning

confidence: 97%

See 1 more Smart Citation

High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria

Ehrhardt

Mockenhaupt

Anemana

et al. 2005

Microbes and Infection

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria

Ehrhardt

Mockenhaupt

Anemana

et al. 2005

Microbes and Infection

View full text Add to dashboard Cite

“…Congestive heart failure is another less common hypoglycemic risk factor. 17–19 Acute pancreatitis and pancreatic cancer have both been associated with hyperglycemia (ie, pancreatogenous diabetes). 20 Given the low prevalence of each of these conditions, we combined them into one category.…”

Section: Methodsmentioning

confidence: 99%

Development and validation of a prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults

Mathioudakis

Everett

Routh

et al. 2018

BMJ Open Diab Res Care

View full text Add to dashboard Cite

ObjectiveTo develop and validate a multivariable prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults.Research design and methodsWe collected pharmacologic, demographic, laboratory, and diagnostic data from 128 657 inpatient days in which at least 1 unit of subcutaneous insulin was administered in the absence of intravenous insulin, total parenteral nutrition, or insulin pump use (index days). These data were used to develop multivariable prediction models for biochemical and clinically significant hypoglycemia (blood glucose (BG) of ≤70 mg/dL and <54 mg/dL, respectively) occurring within 24 hours of the index day. Split-sample internal validation was performed, with 70% and 30% of index days used for model development and validation, respectively.ResultsUsing predictors of age, weight, admitting service, insulin doses, mean BG, nadir BG, BG coefficient of variation (CVBG), diet status, type 1 diabetes, type 2 diabetes, acute kidney injury, chronic kidney disease (CKD), liver disease, and digestive disease, our model achieved a c-statistic of 0.77 (95% CI 0.75 to 0.78), positive likelihood ratio (+LR) of 3.5 (95% CI 3.4 to 3.6) and negative likelihood ratio (−LR) of 0.32 (95% CI 0.30 to 0.35) for prediction of biochemical hypoglycemia. Using predictors of sex, weight, insulin doses, mean BG, nadir BG, CVBG, diet status, type 1 diabetes, type 2 diabetes, CKD stage, and steroid use, our model achieved a c-statistic of 0.80 (95% CI 0.78 to 0.82), +LR of 3.8 (95% CI 3.7 to 4.0) and −LR of 0.2 (95% CI 0.2 to 0.3) for prediction of clinically significant hypoglycemia.ConclusionsHospitalized patients at risk of insulin-associated hypoglycemia can be identified using validated prediction models, which may support the development of real-time preventive interventions.

show abstract

Carbohydrates

Khan¹

2011

Henry's Clinical Diagnosis and Management by Laboratory Methods

View full text Add to dashboard Cite

Spontaneous Hypoglycemia Associated with Congestive Heart Failure Attributable to Hyperinsulinism

Cited by 6 publications

References 4 publications

High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria

High levels of circulating cardiac proteins indicate cardiac impairment in African children with severe Plasmodium falciparum malaria

Development and validation of a prediction model for insulin-associated hypoglycemia in non-critically ill hospitalized adults

Carbohydrates

Contact Info

Product

Resources

About