Spontaneous Lysis of Aspergillomata

Hammerman, Kenneth J.; Christianson, Charles S.; Huntington, Ione; Hurst, George A.; Zelman, Morris; Tosh, Fred E.

doi:10.1378/chest.64.6.697

Cited by 70 publications

(20 citation statements)

References 9 publications

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“…Most are stable and do not progress under observation. Some increase in size and ,10% resolve spontaneously [74]. Data from our centre (Inova Fairfax Hospital) suggest that the presence of aspergillomas does appear to be associated with worse outcomes ( fig.…”

Section: Parenchymal Complications Cavities and Mycetomasmentioning

confidence: 74%

Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation

Shlobin¹,

Nathan²

2012

Eur Respir J

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Sarcoidosis is not only a multisystem, but also a multinational disease that is prevalent throughout the world, including Europe, the USA and Japan. Lung involvement in sarcoidosis is seemingly invariable, with up to 95% of patients manifesting some form of pulmonary disease during the course of their lifetime. The natural history of sarcoidosis in the lung is quite variable and spans the spectrum from spontaneous resolution to advanced fibrocystic disease in ,5% of cases. Advanced sarcoidosis will be the subject of this review with a special focus on pulmonary hypertension and lung transplantation as a last-resort treatment option for some patients with end-stage disease.

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Section: Parenchymal Complications Cavities and Mycetomasmentioning

confidence: 74%

Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation

Shlobin¹,

Nathan²

2012

Eur Respir J

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“…Somepatients are asymptomatic or symptomsmay resolve spontaneously while some manifest with tissue damageand severe symptoms(particularly, lifethreatening hemoptysis) (1)(2)(3). However, there is a lack of serummarkers that reflect their symptomssuch as hypoxia and the likelihood of developing hemoptysis (4,5).…”

Section: Discussionmentioning

confidence: 99%

“…Someare asymptomatic or symptomsmayresolve spontaneously (1,2) while some manifest with severe symptoms such as life-threatening hemoptysis (3). There is also a lack of serumscreening markers to evaluate the severity of PA (4,5).…”

Section: Introductionmentioning

confidence: 99%

“…Vascular endothelial growth factor (VEGF), a cytokine associated with malignant neoplasms (6), has recently been reported to be associated with inflammatory diseases (7,8). However, little is known about VEGFin PA, an inflammatory disorder caused by Aspergillusfumigatus ( 1 ). In order to clarify the predictive value of VEGFin PA, we measuredserum VEGF levels in PA patients and performed immunohistochemical analysis of VEGFin resected lungs of PA patients.…”

Section: Introductionmentioning

confidence: 99%

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Expression of Vascular Endothelial Growth Factor in Pulmonary Aspergilloma.

et al. 2001

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“…The entire procedure was repeated three times a day. After four days in hospital the treatment was completed on an outpatient basis for a total of 5-6 g potassium iodide (15)(16)(17)(18)(19)(20) …”

Section: Resultsmentioning

confidence: 99%

Topical treatment of life threatening haemoptysis from aspergillomas.

Rumbak

Köhler

Eastrige

et al. 1996

Thorax

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Background -The efficacy oftopical treatment of 12 episodes of severe life threatening haemoptysis from a pulmonary aspergilloma in 11 patients is reviewed. Methods -A retrospective review was performed on five white and six AfricanAmerican patients of mean age 49 years. The underlying diseases were bronchiectasis, sarcoidosis, tuberculosis, or histoplasmosis. The patients were prospectively considered poor surgical risks because they had a forced expiratory volume in one second (FEV1) of <50% predicted and an arterial oxygen tension (Pao2) of <7*95 kPa breathing room air. As surgical intervention was not possible, local intracavitary instillation of sodium or potassium iodide was performed. Two patients were previously treated with amphotericin B. In one patient sodium iodide alone was used and in the remaining eight potassium iodide alone was instilled. The transcricothyroid approach was used in six patients and the percutaneous approach in five. Results -Haemoptysis ceased within 72 hours in all patients after the instillation of sodium or potassium iodide. There was no morbidity or mortality, and side effects included slight irritation on instillation of the iodide solution and occasional cough which was easily controlled. All patients were alive at least one year later.Conclusion -Intracavitary treatment is a viable option in the poor risk patient with life threatening haemoptysis from an aspergilloma. (Thorax 1996;51:253-255) Keywords: haemoptysis, Aspergillus, topical treatment.Haemoptysis is the most common complication of a pulmonary aspergilloma occurring in up to 74% of cases.' Massive haemoptysis (> 600 ml/24 hours) has been fatal in 28% of these patients.2 Surgical resection remains the treatment of choice for patients with adequate pulmonary reserve. 12 Even in cases with a good pulmonary reserve, 5% of patients in one series died of complications after surgery and 15% of the survivors developed significant haemorrhage and bronchopleural fistulae.3 There are many patients whose general medical condition precludes surgical resection and topical treatment with various drugs has been attempted.

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Spontaneous Lysis of Aspergillomata

Cited by 70 publications

References 9 publications

Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation

Management of end-stage sarcoidosis: pulmonary hypertension and lung transplantation

Expression of Vascular Endothelial Growth Factor in Pulmonary Aspergilloma.

Topical treatment of life threatening haemoptysis from aspergillomas.

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