Spontaneous normalization of ovarian function and pregnancy in a patient with resistant ovary syndrome

Mueller, Andreas; Berkholz, Alexander; Dittrich, Ralf; Wildt, L.

doi:10.1016/s0301-2115(03)00211-2

Cited by 13 publications

(13 citation statements)

References 7 publications

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“…Mueller et al [3] reported there was no indication for any autoimmune disease in a patient with ROS and tests for antinuclear antibodies, antiphospholipid antibodies, lupus anticoagulant and anticardiolipin antibodies were all negative. Arici et al [4] also found no autoantibodies against thyroid, adrenals, or ovaries in two women with ROS.…”

Section: Discussionmentioning

confidence: 99%

“…Attempts to stimulate follicle development with high doses of gonadotropins to override the resistant state seem to be invalid [3, 4, 6]. Indeed we tried to induce follicle growth with 300IU daily hp-HMG for 15 days, but no response.…”

Section: Discussionmentioning

confidence: 99%

“…Little progress has been made in term of reproduction with the patient’s own gamete. Several researchers have reported successful return of menstruation after ovarian biopsy, normalization of ovarian function and subsequent spontaneous pregnancy after hormone replacement therapy in very few cases [2, 3]. Patients with ROS usually have to accept egg donation because ovarian follicles were unresponsive to endogenous or exogenous FSH [4].…”

Section: Introductionmentioning

confidence: 99%

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Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes

Pan

Yuan

et al. 2016

J Ovarian Res

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BackgroundResistant ovary syndrome (ROS) is a rare endocrine disorder characterized with hypergonadotrophic hypogonadism. Infertility is a common complaint of woman presenting with ROS, and little progress has been made in term of reproduction with the patient’s own gamete. So far only one case report of live birth has been reported after in vitro maturation (IVM) of oocytes in a patient suffering from ROS in 2013.Case presentationA secondary infertile woman of 33 years-old was manifested with oligomenorrhea and markedly increased gonadotropin levels around postmenopausal range, but had normal antral follicle count, normal serum inhibin B and anti-Müllerian hormone levels. She had normal karyotype of 46,XX and normal thyroid function. There were no abnormal findings in some autoantibody assays and FSH receptor sequencing. After oral contraceptive pills combined with triptorelin depot were administered, her gonadotropin levels reduced but it showed no response to high doses of exogenous gonadotropins (hp-HMG 300IU/d for 15 days). Then endometrium was prepared with estradiol valerate and IVM from small antral follicles were performed. Five immature oocytes were retrieved. Twenty-four hours after IVM culture, 3 oocytes matured to metaphase II stage and were inseminated by intracytoplasmic sperm injection using her husband’s sperm. Two top-quality embryos were transferred and one embryo was cryopreserved. The patient got pregnant and delivered a healthy boy at term.ConclusionIVM using their own oocytes could be an available treatment for infertile women with ROS.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes

Pan

Yuan

et al. 2016

J Ovarian Res

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“…Some cases of ROS could even recover spontaneously (Mueller et al, 2003), while other ROS had amenorrhea in general, but could get pregnant through hormone therapy more than once (Aslam et al, 2004). Therefore, the treatment of ROS is also according to the severity of the disease.…”

Section: Discussionmentioning

confidence: 99%

Birth Achieved After Effective Ovarian Stimulation Combined With Dexamethasone in a Patient With Resistant Ovary Syndrome: A Case Report and Review of the Literature

H¹,

Chang²,

Mei³

et al. 2020

Preprint

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Background: Resistant ovary syndrome (ROS) was a rare endocrine disorder and there have been few reports of live births. As the ovarian resistance to FSH leading the immature oocytes, some researchers reported few live births after in vitro maturation (IVM) of oocytes, but it didn’t work in all ROS patients. Case presentation: A 30-year-old woman was diagnosed as ROS. GnRH analogue triptorelin acetat was used to administer downregulation, combining with corticosteroid dexamethasone (administered orally at 0.75mg three times daily) from the beginning of the downregulation to the day of oocyte collection. After 28 days of downregulation, gonadotropin (Gonal-f 225 IU and HMG 150 IU per day at first) was given for hyperstimulation. On the 11th day of gonadotropin administration, 10000 IU of hCG was given. 36h later, oocytes were retrieved and followed by IVF procedure. Two months later, the frozen embryos were thawed and transferred. 8 metaphase II oocytes were retrieved and 3 embryos were developed, in which 1 embryo was transplanted after thawed. the β-hCG value in serum was 246.7 mIU/ ml. The patient got pregnant and gave a live birth at the 35th week of pregnancy by Caesarean section. Conclusion This is the first report about treatment ROS patient with ovarian stimulation combined with dexamethasone. In some cases of ROS, high doses of exogenous gonadotropins in combination with immunosuppressive therapy could be an effective approach in patients with ROS.

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“…하지만 다른 나라(북미, 브라질, 일본, 스위스)에서는 이 점돌연변이가 관찰되 지 않았다 [9]. 임상경과를 보면 호르몬 보충요법을 통해 자연임신이 성공된 경우가 보고되고 있고 [10], 난자공여를 통해 배아이식으로 임신에 성공한 경우 도 보고되고 있다 [11]. 일반적으로 조기난소부전 여성의 치료는 46, XX 염색체를 가진 여성에게는 호르몬 보충요법을 하는 것이 필요하다.…”

unclassified

A case of resistant ovary syndrome

Kim

Jeong

et al. 2012

Korean J Obstet Gynecol

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A 21-year-old female with primary amenorrhea, sexual infantilism, and phenotypic female visited our Obstetrics and Gynecology Clinics. The patient showed elevated follicle stimulating hormone and luteinizing hormone, decreased estradiol, normal thyroidstimulating hormone and prolactin level that means hypergonadotropic hypogonadism with normal 46, XX karyotype. Under diagnostic laparoscopy, both ovaries were intact morphology, small but anatomically normal uterus and vagina. Ovarian biopsy was taken and reported abundant primodial follicles and sporadic preantral follicles. We concluded that final diagnosis is resistant ovarian syndrome.

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Spontaneous normalization of ovarian function and pregnancy in a patient with resistant ovary syndrome

Cited by 13 publications

References 7 publications

Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes

Successful live birth in a woman with resistant ovary syndrome following in vitro maturation of oocytes

Birth Achieved After Effective Ovarian Stimulation Combined With Dexamethasone in a Patient With Resistant Ovary Syndrome: A Case Report and Review of the Literature

A case of resistant ovary syndrome

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