Spontaneous pineal body tumours (pinealomas) in Wistar rats; a histological and ultrastructural study

Zubaidy, A. J. Al; Malinowski, Witold

doi:10.1258/002367784780958295

Cited by 11 publications

(13 citation statements)

References 11 publications

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“…Lymphoma and leukemia accounted for 6% of neoplasms, slightly less than the incidence of 11% noted in our first review and much less than the high frequency of large granular cell leukemia in F344 rats (Solleveld et al, 1984). Neoplasms of nervous system are uncommon in Wistar rats (Dagle et al, 1979;Sumi et al, 1976;Al Zubaidy and Malinowski, 1984;Maekawa et al, 1984) and in this review accounted for 2.1% of tumors in 2.3% of all rats. Unlike our previous review in which astrocytomas were the most common neural neoplasm, granular cell meningiomas were the most common neoplasm in this review.…”

Section: Discussionsupporting

confidence: 46%

Spontaneous Neoplasms in Control Wistar Rats: A Comparison of Reviews

Poteracki¹

1998

Toxicological Sciences

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Section: Discussionsupporting

confidence: 46%

Spontaneous Neoplasms in Control Wistar Rats: A Comparison of Reviews

Poteracki¹

1998

Toxicological Sciences

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“…Based on present findings, this tumor was diagnosed as benign. The formation of a rosette or a pseudo-rosette pattern and smooth muscle fibers in the such stroma have also described in the pineal gland tumors in rats [1,6,9,12], but there were no findings in the present case.…”

supporting

confidence: 41%

“…The malignant pineal gland tumor is characterized by cellular pleomorphism, high mitotic activity, necrosis, and, most important, invasive growth into adjacent tissue [1,8,12]. However, it has been reported that high mitotic activity is common in benign pineal gland tumors in rats [3,[9][10][11]13].…”

mentioning

confidence: 99%

Spontaneous Pinealoma in a Male Crj:CD(SD)IGS Rat.

Furukawa

Kobayashi

Usuda

et al. 1999

The Journal of Veterinary Medical Science

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ABSTRACT. A pinealoma (benign) was found in a 61-week-old male Crj:CD (SD) IGS rat. The neoplasm was located between the cerebral hemispheres and the cerebellum. Histologically, the tumor cells consisted of two cell types: large, pale-staining cells and small darkstaining cells. A fibrovascular stroma divided the tumor cells into incomplete lobules or nest structures. Relatively numerous mitoses were noted in the tumor cells. Ultrastructurally, the tumor cells contained dense-cored vesicles, approximately 120 nm in diameter.-KEY WORDS: Crj:CD (SD) IGS, pinealoma (benign), pinealoma (spontaneous).

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“…( Al Zubaidy and Malinowski 1984 ; Botts et al 1994 ; Capen et al 2001 ; Coca et al 1992 ; Fraser 1986 ; Furukawa et al 1999 ; Götz et al 1992 ; Heath and Winokur 1998 ; Hirato and Nakazato 2001 ; Jouvet et al 2006 ; Koestner and Solleveld 1996 ; Korf et al 1990 ; Krinke et al 1985 ; Krinke et al 2000 ; Maekawa et al 1984 ; Rubinstein 1972 ; Schachner et al 1984 ; Treumann et al 2015 ; Vogel and Fuller 2003 ; Walker et al 1994 ; Yamamoto et al 1991 )…”

Section: Pineal Glandunclassified

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

Brändli-Baiocco

Balme

Bruder³

et al. 2018

J Toxicol Pathol

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The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions in Rats and Mice) Project (www.toxpath.org/inhand.asp) is a joint initiative among the Societies of Toxicological Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) and North America (STP) to develop an internationally accepted nomenclature for proliferative and nonproliferative lesions in laboratory animals. The purpose of this publication is to provide a standardized nomenclature for classifying microscopic lesions observed in the endocrine organs (pituitary gland, pineal gland, thyroid gland, parathyroid glands, adrenal glands and pancreatic islets) of laboratory rats and mice, with color photomicrographs illustrating examples of the lesions. The standardized nomenclature presented in this document is also available electronically on the internet (http://www.goreni.org/). Sources of material included histopathology databases from government, academia, and industrial laboratories throughout the world. Content includes spontaneous and aging lesions as well as lesions induced by exposure to test materials. A widely accepted and utilized international harmonization of nomenclature for endocrine lesions in laboratory animals will decrease confusion among regulatory and scientific research organizations in different countries and provide a common language to increase and enrich international exchanges of information among toxicologists and pathologists.

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Spontaneous pineal body tumours (pinealomas) in Wistar rats; a histological and ultrastructural study

Abstract: SummaryThe pathology of 5 cases of pinealomas in Wistar rats used in long-term toxicological studies is described both grossly, microscopically and ultrastructurally, together with a review of the related literature.

Cited by 11 publications

References 11 publications

Spontaneous Neoplasms in Control Wistar Rats: A Comparison of Reviews

Spontaneous Neoplasms in Control Wistar Rats: A Comparison of Reviews

Spontaneous Pinealoma in a Male Crj:CD(SD)IGS Rat.

Nonproliferative and Proliferative Lesions of the Rat and Mouse Endocrine System

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