Spontaneous production of eosinophil chemotactic factors by T lymphocytes from patients with subcutaneous angioblastic lymphoid hyperplasia with eosinophilia

Hirashima, Mitsuomi; Sakata, K; Tashiro, Kazuhiro; Ohmori, Jun; Iyama, Ken‐ichi; Tsuda, Hideo; Nagai, Tomoko; Hiraoka, Tomoko; Kimura, Tetsunori

doi:10.1016/0090-1229(86)90087-5

Cited by 13 publications

(4 citation statements)

References 10 publications

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“…[6], In addition, it is well-documented that activated helper T cells augment B cells functions. Therefore, Kimura's disease with lymphoid follicles and high IgE might be precipitated by the activation of CD4* cells.…”

Section: Discussionmentioning

confidence: 99%

Kimura’s Disease with Marked Proliferation of HLA-DR+CD4+ T Cells in the Skin, Lymph Node and Peripheral Blood

Tabata¹,

Ishikawa²,

Ohnishi³

et al. 1992

Dermatology

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A 41-year-old female had atopic dermatitis-like skin lesions since the age of 21, and for the past 6 years many skin tumors developed on the body, lower extremities and other areas. The histological picture of the tumor, eosinophilia and high IgE in the peripheral blood were consistent with a diagnosis of Kimura’s disease. Although the tumors were markedly reduced by oral prednisolone administration, thereafter papules appeared disseminated over the body with swelling of superficial lymph nodes. Immunohistochemical examination indicated marked proliferation of HLA-DR⁺CD4⁺ T cells in the skin and lymph nodes, and two-color flow cytometry confirmed it in the lymph nodes and peripheral blood.

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Section: Discussionmentioning

confidence: 99%

Kimura’s Disease with Marked Proliferation of HLA-DR+CD4+ T Cells in the Skin, Lymph Node and Peripheral Blood

Tabata¹,

Ishikawa²,

Ohnishi³

et al. 1992

Dermatology

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“…LDECF-HES (pi about 6) is produced by OKT4-positive T cells of patients with Kimura's disease [3][4][5], and another ECF, LDECF-PD (pi 8) is produced by OKT4-positive T cells of patients infected with Schistosoma mansoni during antigen or mitogen stimulation [6], The biological functions of LDECF-HES differ from those of LDECF-PD in Fcreceptor expression and effects on eosinophil cationic protein (ECP): the former potentiates FceRII expression and does not affect ECP release, while the latter poten tiates FcyRIII and suppresses ECP release [7], Further more, our established T cell line, STO-2, produces at least five ECF having different pi (5, 6, 7, 8, and 9) [8]. These five STO-2-derived ECF exhibit different biological func tions in enhancement of eosinophil survival, induction of eosinophilic-specific granules, and Fc-receptor expression [8], Among the STO-2-derived ECF, ECF-P17 (M.W.…”

Section: Properties Of Ball-1-induced Ecfmentioning

confidence: 99%

A B Cell Lymphoma Line, BALL-1 Stimulates T Cells to Produce a Unique Eosinophil Chemotactic Factor

Yoshida

Ueno²,

Saita³

et al. 1994

Int Arch Allergy Immunol

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Human mononuclear leukocytes (MNL), probably OKT4-positive T cells, produced an eosinophil chemotactic factor (ECF) when they were cocultured with irradiated BALL-1, a B cell lymphoma line. Treatment of MNL, with anti-IL-2 antibody failed to suppress BALL-1-induced ECF production. Periodate-lysine-paraformaldehyde-fixed but not acetone- and ethanol-fixed BCLL induced evident ECF production. These results suggested that some cell surface molecules play a role in the induction of ECF production. Isoelectric point of BALL-1-induced ECF was around pH 7, whereas that of IL-2-induced ECF was around pH 5. The molecular weight of BALL-1-induced ECF was between 10 and 30 kD. Although a combination of MoAb against IL-3, IL-5, and GM, CSF suppressed the activity of IL-2-induced ECF, it failed to suppress that of BALL-1-induced ECF. Furthermore, BALL-1-induced ECF suppressed fMLP-induced respiratory bursts of eosinophils, while IL-2-induced ECF failed. We propose that at least one reason for eosinophil infiltrate into the stroma of tumors is that the tumor cells stimulate T cells to produce BALL-1-induced ECF, and the eosinophils attracted by the ECF exhibit different functions from those by other ECF.

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“…We have shown that OKT4-positive T cells from patients with Kimura's disease produce an eosinophil chemotactic factor, LDECF-HES, and that T cells from patients with Schistosoma mansoni infection produce another ECF, LDECF-PD [1][2][3][4]. Both ECF exhibit differ ent biological functions on eosinophils in Fc-receptor expression, and release and intracellular level of eosino phil cationic protein [5], We have recently established a T cell line, ST02, constitutively producing 5 different ECF, (ECF-P15, ECF-P16, ECF-P17, ECF-P18 and ECF-P19) [6], They have functional heterogeneity in Fc-receptor expression, enhancement of eosinophil survival, and in duction of eosinophil specific granules.…”

Section: Introductionmentioning

confidence: 99%

Effects of Eosinophilotropic Cytokines on Differentiation of an Eosinophil Cell Line, YY-1

Ueno

Watanabe

Tsurufuji

et al. 1994

Int Arch Allergy Immunol

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Differentiation of an eosinophilic cell line, YY-1, was induced by treatment with 0.3 mM butyric acid (BA). The effects of eosinophilotropic cytokines, such as IL-3, IL·5, and GM-CSF on BA-induced differentiation, especially in the chemotactic response to ECF, was examined. Five STO-2-derived ECFs, IL·5, C5a, and fMLP were used as eosinophil chemoattractants. The effects of the cytokines on the chemotactic response of YY-1 greatly differed according to the ECF used. It was thus suggested that heterogeneity in the chemotactic response of eosinophils depends on the cytokines which act on eosinophils during differentiation.

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Spontaneous production of eosinophil chemotactic factors by T lymphocytes from patients with subcutaneous angioblastic lymphoid hyperplasia with eosinophilia

Cited by 13 publications

References 10 publications

Kimura’s Disease with Marked Proliferation of HLA-DR<sup>+</sup>CD4<sup>+</sup> T Cells in the Skin, Lymph Node and Peripheral Blood

Kimura’s Disease with Marked Proliferation of HLA-DR<sup>+</sup>CD4<sup>+</sup> T Cells in the Skin, Lymph Node and Peripheral Blood

A B Cell Lymphoma Line, BALL-1 Stimulates T Cells to Produce a Unique Eosinophil Chemotactic Factor

Effects of Eosinophilotropic Cytokines on Differentiation of an Eosinophil Cell Line, YY-1

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