Spontaneous Regression of Non-Small Cell Lung Cancer in a Patient with Idiopathic Pulmonary Fibrosis: A Case Report

Hwang, Eu Dong; Kim, Young Jae; Leem, Ah Young; Ji, Ah Young; Choi, Youn Jeong; Jung, Ji Ye; Kim, Se Kyu; Chang, Joon; Park, Ji Hye; Park, Seon Cheol

doi:10.4046/trd.2013.75.5.214

Cited by 9 publications

(10 citation statements)

References 13 publications

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“…Spontaneous regression (SR) implies the complete or partial, temporary or permanent disappearance of some or all parameters of malignant disease without or with adequate medical treatment . SR of metastatic non‐small cell lung cancer (NSCLC) is typically characterized by the synchronous reduction of primary and metastatic tumors . Herein, we present a rare case of the SR pattern in a patient with NSCLC and autoimmune disease in whom the primary tumor regressed after biopsy, but metastasis of mediastinal lymph nodes progressed.…”

Section: Introductionmentioning

confidence: 99%

“…1 SR of metastatic non-small cell lung cancer (NSCLC) is typically characterized by the synchronous reduction of primary and metastatic tumors. [2][3][4][5][6][7][8][9][10][11] Herein, we present a rare case of the SR pattern in a patient with NSCLC and autoimmune disease in whom the primary tumor regressed after biopsy, but metastasis of mediastinal lymph nodes progressed.…”

Section: Introductionmentioning

confidence: 99%

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Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report

et al. 2018

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Spontaneous regression (SR) of cancer implies the partial or complete disappearance of malignant disease without or with adequate medical treatment. Typically, SR of cancer is a sporadic event, especially in non‐small cell lung cancer (NSCLC). Although the underlying mechanism of SR remains unknown, stimulation of an immunological response has been proposed. Herein, we report the case of a 56‐year‐old woman exhibiting SR of NSCLC with a mediastinal disease. Despite regression of the primary site after a lung biopsy, simultaneous progression of mediastinal lymph node metastasis occurred. Specimens obtained by surgical resection pathologically confirmed both primary and metastatic sites. Reportedly, primary and metastatic tumors shrink synchronously in SR of metastatic NSCLCs. Thus, the fact that the SR of NSCLC can present inconsistent development in primary and metastatic sites should be considered, and direct intervention is recommended if physicians diagnose this phenomenon.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report

et al. 2018

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“…Tumor regression, a complete or partial disappearance of malignant tumors without any treatment, is not rare and frequently reported in carcinoma of the urinary bladder, renal adenocarcinoma, embryonal and breast cancer, neuroblastoma, melanoma and sarcoma (22). There were also case reports of tumor regression in lung cancer (23,24). The regression phenomena may be associated with bacterial, viral, fungal infection, which can stimulate the immune system of our body.…”

Section: Discussionmentioning

confidence: 99%

Volume doubling time of lung adenocarcinomas considering epidermal growth factor receptor mutation status of exon 19 and 21: three-dimensional volumetric evaluation

et al. 2017

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Background: The current study was to investigate the volume doubling time (VDT) of lung adenocarcinomas considering epidermal growth factor receptor (EGFR) mutation status of exon 19 and 21, when compared with EGFR wide type.Methods: Eighty-eight patients with pathologically proven adenocarcinomas, which underwent two or more computed tomography (CT) scans spared by 25 or more days, were included. EGFR mutations at exons 19 and 21 were determined using amplification refractory mutation system and all patients were divided into three groups-EGFR wide type group, EGFR mutation in exon 19 and 21 groups. Threedimensional manual segmentations for all tumors were performed on first and latest follow-up CT scans; subsequently, VDTs were calculated and compared among three groups. Clinicopathoradiologic characters were also collected for subgroup analysis.Results: EGFR mutations occurred in 49 (55.7%) patients, 19 in exon 19 and 30 in exon 21, respectively.The median VDT of all patients (33 men, 55 women; median age, 62 years) was 214 days (range, −4,092 to 10,920 days). Highly differentiated adenocarcinomas (median, 408 days) demonstrated longer VDT than those moderately (median, 172 days) or poorly (median, 144 days) differentiated (P=0.04). The VDT distribution was similar among EGFR wide type group (median, 207 days), EGFR mutation in exon 19 group (median, 288 days) and exon 21 group (median, 144 days) (P=0.21). In subgroup analysis, the median VDT of adenocarcinomas with EGFR mutation in exon 19 was longer than that of EGFR wide type for males (P=0.03) or patients without spiculation sign in chest CT (P=0.04). Totally 24 adenocarcinomas presented negative VDTs, most of which tended to be stable. Positive VDT values were used for all median description.Conclusions: Overall VDT of lung adenocarcinomas seems not affected by EGFR mutation status.Researches with large population are warranted for further study.

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“…SR seems even more uncommon in NSCLC [4,5,17]. To our knowledge only 15 cases of SR of NSCLC have been described in the literature [5][6][7][8][9][10][11][12][13][14][15][16]. The mechanisms for spontaneous regression are entirely hypothetical and the pathophysiology remains unclear.…”

Section: Discussionmentioning

confidence: 99%

“…Most of these cases concerned metastatic disease of malignancies that originated outside the thoracic cavity such as renal cell carcinoma (60%), hepatocellular carcinoma, endometrial stromal sarcoma, pleomorphic liposarcoma, esophageal cancer and leiomyosarcoma [5]. Only a few case reports described spontaneous regression of primary thoracic malignancies [5][6][7][8][9][10][11][12][13][14][15][16]. Here, we report on a case of spontaneous regression of pathologically proven non-small-cell lung cancer (NSCLC).…”

Section: Introductionmentioning

confidence: 99%

Spontaneous Regression of Large Cell Carcinoma of the Lung, a Case Report

Kwint

Heuvel²,

Snijders³

et al. 2015

OMICS J Radiol

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Spontaneous regression of malignancies are a rare biological phenomenon, especially in lung cancer. Here, we present a case of an 80-year old man, with a cT2aN3M1b non-small cell lung cancer of the left upper lobe, whose tumor regressed spontaneously without any treatment. The cause of the spontaneous tumor remission remains unknown in this case. We describe this rare case and review the literature pertaining to spontaneous regression of lung cancer.

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Spontaneous Regression of Non-Small Cell Lung Cancer in a Patient with Idiopathic Pulmonary Fibrosis: A Case Report

Cited by 9 publications

References 13 publications

Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report

Spontaneous regression of lung squamous cell carcinoma with synchronous mediastinal progression: A case report

Volume doubling time of lung adenocarcinomas considering epidermal growth factor receptor mutation status of exon 19 and 21: three-dimensional volumetric evaluation

Spontaneous Regression of Large Cell Carcinoma of the Lung, a Case Report

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