Spontaneous Regression of Primary Malignant Lymphoma of the Stomach in Two Nontreated Japanese

Shigematsu, Akihiro; Iida, Mitsuo; Lien, Gi Shih; Imamura, Tatsuya; Okada, Mitsuo; Fuchigami, Takeshi; Fujishima, Masatoshi; Itoh, Hideaki; Iwashita, Akinori

doi:10.1097/00004836-198910000-00006

Cited by 14 publications

(9 citation statements)

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“…Shigematsu et al 13 . found massive reactive small lymphocytes in the residual tissue after the regression of the gastric malignant lymphoma and Ohgi et al 14 .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of malignant lymphoma of the breast

Iihara

Yamaguchi

Nishimura

et al. 2004

Pathology International

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A complete spontaneous regression of diffuse large B cell lymphoma involving the right breast, confirmed by aspiration cytology, is reported. The patient visited a hospital due to the rapid growth of a tumor in the right breast. Five years previously she underwent a craniotomy for a brain tumor, diagnosed as B-cell malignant lymphoma, and received several courses of irradiation to the brain. Analysis of the breast tumor cells obtained by aspiration revealed lymphoma cells morphologically, which were similar to the tumor cells in the brain expressing CD20. While waiting for further examination, the tumor regressed rapidly and was not palpable after 20 days. An excisional biopsy of the breast exhibited no definite malignant lymphoma cells among a diffuse population of CD45RO and CD8-positive small lymphocytes. Nucleotide sequencing of HCDR3s of the brain tumor and breast tumor cells showed a completely matched sequence, revealing the breast mass to be a metastatic lesion from the tumor of the brain. Although there was no tumorous lesion, the patient received additional chemotherapy and has shown no sign of recurrence in the breast for 7 years. We were able to confirm that the breast lymphoma shown in the aspiration cytology was a metastatic one, which was not proven histologically prior to chemotherapy, and regard the present case as a malignant lymphoma of the breast showing spontaneous regression. The present case shows a rare occurrence of spontaneous regression of diffuse large B cell malignant lymphoma after aspiration and suggests that CD8-positive T cells might be related to the regression.

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“…Shigematsu et al 13 . found massive reactive small lymphocytes in the residual tissue after the regression of the gastric malignant lymphoma and Ohgi et al 14 .…”

Section: Discussionmentioning

confidence: 99%

Spontaneous regression of malignant lymphoma of the breast

Iihara

Yamaguchi

Nishimura

et al. 2004

Pathology International

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“…Table 1 shows 15 reported cases of SR in aggressive NHL except for the gastric type in patients without any anti-neoplastic treatments till relapse. Several gastric ML cases showing SR have been reported [21][22][23] . However, those cases were not included in table 1 because observations of those tumors require endoscopic examinations, and resection of gastric tumors is usual-ly performed as the first therapy.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous Regression of Diffuse Large B-Cell Lymphoma Harbouring Epstein-Barr Virus: A Case Report and Review of the Literature

Abe

Ogawa

Maruyama

et al. 2007

J Clin Exp Hematopathol

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We report an elderly patient with diffuse large B cell lymphoma harbouring Epstein-Barr virus that showed spontaneous regressions with subsequent relapses three times. The patient died of aspiration pneumonia without any anti-neoplastic treatment 5 years 10 months after the initial onset of lymph node swelling. In the literature, there are several reports of aggressive non-Hodgkin's lymphoma cases that showed spontaneous regressions without relapse till the last observation. Over half of the cases were the extra-nodal type. The tendency toward regression of swollen lymph nodes detected by clinicians occurs within 2 weeks after biopsy. If the remaining lymph nodes show a tendency to decrease in size after biopsy without any anti-tumor therapies, the patient may develop spontaneous regression.

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“…However, this NHL with aggressive histology temporarily underwent spontaneous regression before treatment. Although spontaneous regression of NHL has been observed to occur in various extranodal sites, including the stomach [9], Waldeyer's ring [10], and the skin [11], this event has not been reported in an adrenal gland (MEDLINE search from 1966 to November 2000).…”

Section: Introductionmentioning

confidence: 99%

Transient spontaneous regression of aggressive non-Hodgkin's lymphoma confined to the adrenal glands

et al. 2001

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A 72-year-old-man with night sweats and a low-grade fever was found to have bilateral adrenal enlargement associated with incipient adrenal insufficiency. Without any intervention, these adrenal lesions regressed spontaneously, accompanied by disappearance of clinical symptoms. Seven months later, however, the lesions became enlarged and exceeded their initial size while remaining confined to the adrenals, associated with reappearance of nights sweats and overt adrenal insufficiency. Upon unilateral laparoscopic adrenalectomy, the lesion proved histopathologically to be diffuse large B cell non-Hodgkin's lymphoma (NHL). After contralateral laparoscopic adrenalectomy and adjuvant chemotherapy, the patient remains alive with no recurrence at 26 months. Treatment with bilateral adrenalectomy and chemotherapy is effective for aggressive NHL confined to bilateral adrenal glands. A transient clinical improvement without treatment was considered to be due to a spontaneous regression of NHL, although we could not confirm the histological results before the regression. Such tumor behavior showing spontaneous regression in spite of aggressive histology may also be related to the favorable outcome, even though regression was transient.

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Spontaneous Regression of Primary Malignant Lymphoma of the Stomach in Two Nontreated Japanese

Cited by 14 publications

References 0 publications

Spontaneous regression of malignant lymphoma of the breast

Spontaneous regression of malignant lymphoma of the breast

Spontaneous Regression of Diffuse Large B-Cell Lymphoma Harbouring Epstein-Barr Virus: A Case Report and Review of the Literature

Transient spontaneous regression of aggressive non-Hodgkin's lymphoma confined to the adrenal glands

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