Transient spontaneous regression of aggressive non-Hodgkin's lymphoma confined to the adrenal glands

Fujiwara, Tetsuro; Kawamura, Minoru; Sasaki, Akira; Asahi, Hiroshi; Sasou, Shunichi; Itoh, Shuu; Hiramori, Katsuhiko

doi:10.1007/s002770100335

Cited by 12 publications

(2 citation statements)

References 17 publications

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“…The final group of tumours reported to regress spontaneously did so without any prior intervention. This phenomenon has been described previously for diffuse large B‐cell lymphomas on rare occasions in the lumbar spine 15 and adrenal glands 16 in a single case each and in the central nervous system 17, 18. In each case the initial diagnosis was radiological, histological confirmation only being made on relapse.…”

Section: Discussionsupporting

confidence: 67%

Spontaneous regression of an EBV‐associated monoclonal large B cell proliferation in the mastoid of a young child following surgical biopsy

McCabe

Hook

Burke

2008

Pediatric Blood & Cancer

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We report the spontaneous regression of an Epstein-Barr virus-associated monoclonal lymphoid proliferation in an immunocompetent child. A 2-year-old male with acute otitis media presented with a right-sided facial palsy secondary to acute mastoiditis. During mastoid decompression a polypoid mass, a histologically diffuse large B cell lymphoma, was found. Staging revealed localized disease. At surgical re-exploration 5 weeks later the disease had resolved. Retrospective serological testing was consistent with an acute Epstein-Barr viral infection and in situ hybridization of the tumour tissue was positive for Epstein-Barr RNA.

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Section: Discussionsupporting

confidence: 67%

Spontaneous regression of an EBV‐associated monoclonal large B cell proliferation in the mastoid of a young child following surgical biopsy

McCabe

Hook

Burke

2008

Pediatric Blood & Cancer

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“…The longest reported survival in a case treated with primary CHOP chemotherapy has been 50 months (Kuyama et al, 2000); the patient achieved a complete remission after 4 cycles, but continued to need steroid replacement. Transient clinical improvement without treatment, considered to be due to spontaneous transient regression of NHL (unconfirmed on histology) inspite of aggressive histology has been reported and may identify a favorable subset of patients (Fujiwara et al, 2001).…”

Section: Discussionmentioning

confidence: 99%

Adrenal Insufficiency Due to Primary Bilateral Adrenal Non-Hodgkin's Lymphoma

Zargar

Laway²,

Bhat³

et al. 2004

Exp Clin Endocrinol Diabetes

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A case of primary adrenal insufficiency, secondary to primary bilateral adrenal lymphoma is reported. A 50-year-old woman presented with features of primary adrenal insufficiency (darkening of skin, asthenia, anorexia, constipation) for at least 8 months. Clinical examination was unremarkable except for low body mass index and generalized skin and buccal mucosal pigmentation. Routine investigations including complete hemogram, serum chemistry, urine analysis, chest radiograph and electrocardiogram were normal; serum lactate dehydrogenase was moderately elevated. Primary adrenal insufficiency was confirmed on cortisol dynamics (very low basal and peak cortisol) after insulin-induced hypoglycemia. Routinely detected adrenal masses on ultrasonography were confirmed by contrast enhanced CT abdomen. A diagnosis of primary adrenal non- Hodgkin's lymphoma (B-cell) was made after exploratory laprotomy and further staging. The patient was put on combination chemotherapy (CHOP) protocol, but was lost to follow-up after receiving two cycles of treatment. Primary adrenal lymphoma, although a rare entity, needs to be suspected in patients with features of primary adrenal insufficiency who have evidence of bilateral adrenal masses on imaging.

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Retracted: Autonomous histopathological regression of primary tumours associated with specific immune responses to cancer antigens

Saleh

Crotty

Hersey

et al. 2003

The Journal of Pathology

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Spontaneous histopathological regression of cancer has been reported. The involvement of the immune system in such regression has been advocated, leading to the theory of immunological surveillance against cancer. A prediction of this theory is that common tumour antigens can be recognized upon repeated exposure by cell-mediated immunity, which leads to tumour regression and the subsequent appearance of tumour antigen-loss variants. However, no direct evidence has been provided in non-viral-induced experimental animal models of primary malignancy or in human primary cancer. This study examined two groups of melanoma patients where histopathological regression of the primary tumour was observed. Many of the 23 patients with multiple (> or =3) primary melanomas showed significant regression of their last melanoma (median 33%, mean 40) compared with matched melanomas from patients with a single primary melanoma (median 0%, mean 12) (p=0.0080), or compared with their first primary melanoma (p=0.0013). Regression was consistent with an 'immunization effect' seen in murine tumour transplantation studies, where inoculation with > or =3 asynchronous tumours induces transplantation rejection on subsequent challenge. A significant decrease in the expression of the melanoma common tumour antigen MART-1 in the last primary tumour from multiple melanoma patients (median 8%, mean 24) versus matched single melanoma patients (median 79%, mean 68) (p=0.0041) and in the last versus first tumour in multiple primary patients was found (p=0.0083). Metastases from 17 patients whose primary skin melanomas had completely regressed (occult primary melanoma) also showed significant MART-1 loss (median 0%, mean 11) compared with matched metastases from patients with non-regressing primary melanoma (median 51%, mean 50) (p=0.0013). MART-1 antigen-loss variants observed in the multiple primary and occult primary patients correlated with the presence of peripheral blood MART-1-specific cytotoxic T lymphocytes (CTLs) (p=0.03). No similar effects were observed with two other melanoma antigens, gp100 and CD63. Thus, in two groups of human melanoma patients, evidence is provided for histopathological tumour regression associated with cancer immune surveillance.

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Transient spontaneous regression of aggressive non-Hodgkin's lymphoma confined to the adrenal glands

Cited by 12 publications

References 17 publications

Spontaneous regression of an EBV‐associated monoclonal large B cell proliferation in the mastoid of a young child following surgical biopsy

Spontaneous regression of an EBV‐associated monoclonal large B cell proliferation in the mastoid of a young child following surgical biopsy

Adrenal Insufficiency Due to Primary Bilateral Adrenal Non-Hodgkin's Lymphoma

Retracted: Autonomous histopathological regression of primary tumours associated with specific immune responses to cancer antigens

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