Spontaneous Remission of Acute Myeloid Leukemia: Report of Three Cases and Review of the Literature

Jain, Nitin; Hubbard, Julie C.; Vega, Francisco; Vidal, Gabriela; Borthakur, Gautam

doi:10.3816/clk.2008.n.008

Cited by 7 publications

(8 citation statements)

References 31 publications

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“…Spontaneous remission of acute myeloid leukemia is an extremely rare and almost always transient event, with a mean duration in the literature of 7.7 months (range 1–36) . Since 1979, approximately thirty cases of AML SR have been reported , although the underlying mechanisms involved remain unclear. A potential role of bacterial and/or fungal infections and blood transfusions was suggested in SR occurrence by triggering an immune and antileukemic response.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous remission in three cases of AML M5 with NPM1 mutation

Camus

Étancelin

Jardin

et al. 2015

Clinical Case Reports

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Section: Discussionmentioning

confidence: 99%

Spontaneous remission in three cases of AML M5 with NPM1 mutation

Camus

Étancelin

Jardin

et al. 2015

Clinical Case Reports

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“…The proinflammatory molecule IL-2, which enhances tumor cytotoxicity by inducing proliferation and activation of T and NK cells, is the cytokine that has been most extensively studied in adult as well as childhood AML [ 12 , 13 ]. Though a rare phenomenon, various case reports have reported spontaneous remission of AML following episodes of infection [ 14 – 17 ], suggesting that triggered T cell-driven immune responses likely via cytokine activation can induce myeloid leukemia cell remission. More specifically, cytokines such as TNF and IL-2, both of which are released during active infections, have been suggested to play a potential role in inducing spontaneous AML remission [ 18 , 19 ].…”

Section: Discussionmentioning

confidence: 99%

Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia

Huang

Owen

Myers

et al. 2015

Case Reports in Hematology

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Background. Childhood AML patients are at increased risk for early fatal pulmonary complications. Pulmonary leukostasis and systemic inflammatory response syndrome (SIRS) following leukemia cell lysis are the likely etiologies. Observation. Soon after initiation of AML chemotherapy, an 18-month-old female who met SIRS criteria sustained cardiopulmonary failure requiring ECMO support. Upon recovery, the patient went on to complete therapy and remains in remission without permanent neurologic or cardiac sequelae. Conclusion. Cytokine release syndrome from rapid cell lysis was the likely cause as infectious workup failed to reveal a definitive etiology and drug hypersensitivity testing to the chemotherapy agents was negative.

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“…Between 1979 and 2008 about thirty patients were described manifesting SR of AML. The median duration of remission was generally short (the mean was about 6 months); however, even long-term and complete cytogenetic remissions were documented [ 9 , 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Infections and/or blood transfusions are postulated as the main causes of SR but there were also patients with SR reported who had neither infections nor transfusions [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Spontaneous hematological remission of acute myeloid leukemia

Kaźmierczak¹,

Szczepaniak²,

Czyż³

et al. 2014

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Spontaneous remission (SR) of acute myeloid leukemia (AML) in adults is observed very rarely. To date, about 100 cases have been presented in the literature. To our best knowledge, we describe the first adult Polish patient suffering from acute myelomonocytic leukemia (48, XY, +13, +21/46, XY), in whom after supportive therapy, including non-irradiated, non-leukocyte depleted red cell transfusions and low-dose corticosteroid, we observed resolution of the disease without cytogenetic remission. We suggest a potential transfusion-associated graft versus-host-diseases (TA-GVHD) and graft-versus leukemia (GVL) reaction which might lead to spontaneous hematological remission. However, we did not observe clinical symptoms of such reactions apart from a short episode of non-infectious diarrhea. Additionally, steroids were administered but their role in inducing SR, in our opinion, seems less probable. This 77-year-old man remained in SR for 7 months, when repeated analysis showed AML recurrence. He died due to septic shock 2.5 months later. Additionally, we present a review of the literature.

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Spontaneous Remission of Acute Myeloid Leukemia: Report of Three Cases and Review of the Literature

Cited by 7 publications

References 31 publications

Spontaneous remission in three cases of AML M5 with NPM1 mutation

Spontaneous remission in three cases of AML M5 with NPM1 mutation

Cardiopulmonary Failure Requiring ECMO Bypass Resulting from Leukemia Cell Lysis in a Patient with Childhood Acute Myelomonocytic Leukemia

Spontaneous hematological remission of acute myeloid leukemia

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