Spontaneous splenic rupture in two patients with a blastoid variant of mantle cell lymphoma

Oinonen, R.; Franssila, Kaarle; Elonen, Erkki

doi:10.1007/s002770050252

Cited by 28 publications

(20 citation statements)

References 9 publications

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“…Pathological rupture of the spleen is most commonly seen in the hematological malignancies [31] , in which fragmentation and dissolution of the fibrous capsule of the spleen occur by infiltrating atypical lymphocytes, as seen in lymphoma or leukemia [20] . Giagounidis et al [32] have reported that male sex, adulthood, severe splenomegaly and cytoreductive chemotherapy are factors that are associated more often with rupture of the spleen in hematological malignancies.…”

Section: Discussionmentioning

confidence: 99%

Non-traumatic splenic rupture: Report of seven cases and review of the literature

Gedik¹,

Gırgın²,

Aldemir³

et al. 2008

WJG

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AIM:To evaluate seven patients with non-traumatic splenic rupture (NSR). NSR is an uncommon dramatic abdominal emergency that requires immediate diagnosis and prompt surgical treatment to ensure the patient's survival. METHODS: Within 11 years, seven cases were evaluated for patient characteristics, anamnesis and symptoms, method of diagnosis, findings of laparotomy, and etiology of NSR. RESULTS: There were six (86%) male and one female (14%) patient, whose mean age was 36 ± 12.8 (17-56) years. We report here four cases of Plasmodium vivax malaria (cases Ⅰ-Ⅳ), one case of hemodialysis (case Ⅴ), one case of spontaneous splenic rupture (case Ⅵ), and one case of hairy cell leukemia (case Ⅶ). Splenectomy was performed in all patients. All of them made an uneventful recovery and were discharged in stable condition. CONCLUSION: NSR is a rare entity that needs a high index of suspicion for diagnosis. Using ultrasonography or computer tomography, and peritoneal aspiration of fresh blood may assist in the diagnosis of NSR. Increased awareness of NSR can enhance early diagnosis and effective treatment.

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Section: Discussionmentioning

confidence: 99%

Non-traumatic splenic rupture: Report of seven cases and review of the literature

Gedik¹,

Gırgın²,

Aldemir³

et al. 2008

WJG

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“…Although MCL typically shows indolent histological features with a low proliferation rate, it is known to have a poorer prognosis than the other small cell lymphomas with a median survival of only 3-4 years. A blastoid variant of MCL shows large nuclei, a high proliferation activity, and an aggressive course [1,13,23,25,36,37]. Typically, MCL is presented in middle-aged or elderly patients [31] who have at diagnosis an advanced disease with generalized lymphadenopathy and often extranodal manifestations such as infiltrations of bone marrow, gastrointestinal tract, spleen, or Waldeyer's ring [1,3,5,6,10,22,24,26,28,35,36,38,39].…”

Section: Introductionmentioning

confidence: 99%

Central nervous system involvement in patients with mantle cell lymphoma

Oinonen

Franssila

Elonen

1999

Annals of Hematology

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In small cell lymphomas, central nervous system (CNS) involvement has been considered to be very rare. Mantle cell lymphoma (MCL) is a distinct subtype of non-Hodgkin's lymphomas consisting of small or intermediate lymphatic B-cells. It has a poorer prognosis than the other small cell lymphomas. Only a few MCL patients with CNS involvement have been reported in the literature to date. We analyzed retrospectively the incidence, clinical characteristics, and outcome of CNS involvement in 94 patients with confirmed MCL treated at one center from 1980 to 1997. Four of the 94 patients (4%) developed CNS lymphoma during the median follow-up of 51 months. The diagnosis was based on clinical, cytological and radiological findings. CNS involvement appeared at 4.6, 56, 66, or 86 months from the diagnosis of MCL. All patients had neurological symptoms and a leukemic disease; two cases were seen with a blastoid morphology. Malignant lymphatic cells were detected in spinal fluid in all cases and parenchymal infiltrations in brain in two. All patients were treated with intrathecal chemotherapy, without response. Survival time after diagnosis of CNS lymphoma ranged from 18 to 55 days. At diagnosis, no adverse prognostic factors predictive of CNS lymphoma were found. CNS involvement was associated with a progressive leukemic disease as a late event or a blastoid transformation. The prognosis of MCL patients with CNS involvement is poor.

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“…It should be considered that undetected structural abnormalities within the spleen may cause nontraumatic splenic rupture. Pathological rupture of the spleen is most commonly seen in the hematological malignancies [20], in which fragmentation and dissolution of the fibrous capsule of the spleen occur by infiltrating atypical lymphocytes, as seen in lymphoma or leukemia [21]. The most common symptom is left upper-quadrant abdominal pain.…”

Section: Discussionmentioning

confidence: 99%

Spontaneous splenic rupture and Anisakis appendicitis presenting as abdominal pain: a case report

Valle

Lopera

Sánchez³

et al. 2012

J Med Case Reports

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IntroductionAnisakidosis, human infection with nematodes of the family Anisakidae, is caused most commonly by Anisakis simplex. Acquired by the consumption of raw or undercooked marine fish or squid, anisakidosis occurs where such dietary customs are practiced, including Japan, the coastal regions of Europe and the United States. Rupture of the spleen is a relatively common complication of trauma and many systemic disorders affecting the reticuloendothelial system, including infections and neoplasias. A rare subtype of rupture occurring spontaneously and arising from a normal spleen has been recognized as a distinct clinicopathologic entity. Herein we discuss the case of a woman who presented to our institution with appendicitis secondary to Anisakis and spontaneous spleen rupture.Case presentationWe report the case of a 53-year-old Caucasian woman who presented with hemorrhagic shock and abdominal pain and was subsequently found to have spontaneous spleen rupture and appendicitis secondary to Anisakis simplex. She underwent open surgical resection of the splenic rupture and the appendicitis without any significant postoperative complications. Histopathologic examination revealed appendicitis secondary to Anisakis simplex and splenic rupture of undetermined etiology.ConclusionsTo the best of our knowledge, this report is the first of a woman with the diagnosis of spontaneous spleen rupture and appendicitis secondary to Anisakis simplex. Digestive anisakiasis may present as an acute abdomen. Emergency physicians should know and consider this diagnosis in patients with ileitis or colitis, especially if an antecedent of raw or undercooked fish ingestion is present. Spontaneous rupture of the spleen is an extremely rare event. Increased awareness of this condition will enhance early diagnosis and effective treatment. Further research is required to identify the possible risk factors associated with spontaneous rupture of the spleen.

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Spontaneous splenic rupture in two patients with a blastoid variant of mantle cell lymphoma

Cited by 28 publications

References 9 publications

Non-traumatic splenic rupture: Report of seven cases and review of the literature

Non-traumatic splenic rupture: Report of seven cases and review of the literature

Central nervous system involvement in patients with mantle cell lymphoma

Spontaneous splenic rupture and Anisakis appendicitis presenting as abdominal pain: a case report

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