Spontaneous Thyroid-containing Teratoma Associated with Impaired Development in the African Clawed Frog, Xenopus laevis

Cheong, Seon Woo; Fukui, Akihiro; Asashima, Makoto; Pfeiffer, Carl J.

doi:10.1053/jcpa.2000.0400

Cited by 14 publications

(8 citation statements)

References 14 publications

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“…In our Xenopus colony, we estimate that such hepatomas affect about 5% of our animals per year. Spontaneous thyroid-containing teratomas have also been described recently in Xenopus laevis (18). This teratoma was associated with developmental defects in multiple sibling frogs suggesting a genetic basis for this disease.…”

Section: Tumor Occurrence In Xenopusmentioning

confidence: 90%

Tumorigenesis and anti-tumor immune responses in Xenopus

Goyos

Robert²

2009

Front Biosci

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Despite intense study, the role of the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia remains elusive. We present here a comparative view of the complex interactions between neoplasia and the host immune system. We provide evidence, in the amphibian Xenopus laevis, consistent with an evolutionarily conserved and crucial role of the immune system in controlling neoplasia, which involves a striking variety of anti-tumoral immune effectors including conventional CTLs, classical MHC class Ia unrestricted CTLs (CCU-CTLs) that interact with nonclassical MHC class Ib molecules, CD8 NKT-like cells and NK cells. We also review the tumors found in X. laevis with an emphasis on thymic lymphoid tumors and a rare ovarian dysgerminoma. Finally, we consider the use of X. laevis for in vivo study of tumorigenesis. Given our current knowledge, the experimental systems already established in X. laevis, and the rapid accumulation of genetic resources for the sister species Silurana (Xenopus) tropicalis, it is our conviction that these species provide an ideal alternative to the murine system for studying tumorigenesis and tumor immunity.

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Section: Tumor Occurrence In Xenopusmentioning

confidence: 90%

Tumorigenesis and anti-tumor immune responses in Xenopus

Goyos

Robert²

2009

Front Biosci

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“…The sections were then stained with H–E (Delafield's hematoxylin–0.5% eosin Y). The histological results of the amphibian teratomas were examined according to the method of Asashima et al (1987) and Cheong et al (2000).…”

Section: Methodsmentioning

confidence: 99%

Numerical variations and spontaneous malformations in the early embryos of the Korean salamander, Hynobius leechii, in the farmlands of Korea

Park

Yoon

Kim³

et al. 2010

Environmental Toxicology

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Embryo sacs of the Korean salamander, Hynobius leechii, were collected from nine farmlands in Gyeongsangnam-Do, Korea, in early spring of 2002 and 2004. The variations in the number of embryos within each embryo sac and the mortality and abnormality rates among the embryos were investigated. We also analyzed the patterns of spontaneous embryonic malformations and the residual chemicals in the soil of the habitats using multiple-residue GC/MS. A total of 79,195 embryos were obtained from 1933 embryo sacs. There were regional variations in the length of individual embryo sacs and the number of embryos in each. The longest embryo sac averaged by region measured 20.67 cm ± 3.51 and was obtained from 2-Banseong in 2002. Of the embryos collected, 13.71% either died or stopped developing, and 3.54% of the hatched embryos developed abnormally; the latter were classified according to the patterns of malformation. External gill dysplasia was the most frequent malformation, and caudal dysplasia, abdominal blisters, and dysplasia of the fin were also observed frequently. Histopathological analysis showed neural tube abnormalities, acrania, curved notochords, thyroid teratoma, and various other kinds of endodermal developmental abnormalities. In the analysis of the residual pesticides in the soil, carbofuran, endosulfan-sulfate, and endosulfan-β were detected in the regions with high mortality and malformation rates. These results indicate that various agricultural chemicals and other unknown factors may cause the aforementioned forms of spontaneous malformations in the embryos of Hynobius leechii.

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“…In our large X. laevis colony, we estimate that such hepatomas affect about 5% of our animals per year. Notably, spontaneous teratomas containing significant thyroid carcinoma components have been described in X. laevis [76]. These teratomas were associated with developmental defects in multiple sibling frogs suggesting a genetic basis for this disease.…”

Section: Evidence Of Neoplasia In Metazoanmentioning

confidence: 99%

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

Robert

2010

Developmental & Comparative Immunology

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Despite intense study in mammals, the different roles played by the immune system in detecting (immunosurveillance), controlling and remodeling (immunoediting) neoplasia, and perhaps in metastasis are not fully understood. In this review, I will present evidence of neoplasia and invasive malignancy, as well as tumor immunity in invertebrates and nonmammalian vertebrates. I will also present a comparative and evolutionary view of the complex interactions between neoplasia and the host immune system. Overall, I wish to go beyond the too simplistic dichotomy between invertebrates with innate immunity that are only affected with benign neoplasia and vertebrates with adaptive immunity that are affected by metastatic malignancies or cancer.

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Spontaneous Thyroid-containing Teratoma Associated with Impaired Development in the African Clawed Frog, Xenopus laevis

Cited by 14 publications

References 14 publications

Tumorigenesis and anti-tumor immune responses in Xenopus

Tumorigenesis and anti-tumor immune responses in Xenopus

Numerical variations and spontaneous malformations in the early embryos of the Korean salamander, Hynobius leechii, in the farmlands of Korea

Comparative study of tumorigenesis and tumor immunity in invertebrates and nonmammalian vertebrates

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