Spontaneously Arising Tumours and Tumour-like Lesions of the Cervix and Uterus in 83 Pet Guinea Pigs ( Cavia porcellus )

Laik-Schandelmaier, Claudia; Klopfleisch, Robert; Schöniger, Sandra; Weiffenbach, G.; Staudacher, Marlies; Aupperle, H.

doi:10.1016/j.jcpa.2017.03.002

Cited by 12 publications

(4 citation statements)

References 24 publications

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“…In a UK survey of 4,590 guinea pig owners, 39.8% reported not knowing the breed of their pet [ 6 ]. This limited awareness or recognition of breed status in guinea pigs is consistent with previous retrospective studies where breed in guinea pigs has either not been recorded or discussed [ 13 , 28 ], or poorly reported in the data [ 14 , 29 ]. In general, bodyweight was highly consistent across the breeds recorded in our study, suggesting limited selection towards extreme conformation as yet in guinea pigs, in contrast to increasing moves towards extreme conformations in pet rabbit breeds [ 30 ].…”

Section: Discussionsupporting

confidence: 87%

Demography, commonly diagnosed disorders and mortality of guinea pigs under primary veterinary care in the UK in 2019—A VetCompass study

O’Neill,

Taffinder,

Brodbelt

et al. 2024

PLoS ONE

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Introduction Guinea pigs are popular as domestic pets but there is limited information on the health of the wider pet population. This study aimed to report demography, commonly diagnosed disorders and mortality of guinea pigs under UK primary veterinary care. Methods Diagnosis and mortality information on guinea pigs was extracted from anonymised UK primary-care clinical records in VetCompass. Results From 51,622 guinea pigs under primary veterinary care during 2019, a specific breed was not recorded in 50,098 (97.05%). Of guinea pigs with information recorded, 23,206 (47.33%) were female and 25,828 (52.67%) were male. There were 1,020 (2.08%) neutered and 48,014 (97.92%) entire. Median adult bodyweight overall was 1.05kg (interquartile range [IQR] 0.90–1.19, range 0.40–2.66). From a random sample of 3,785/51,622 (7.33%) guinea pigs, the most prevalent disorders were overgrown nail(s) (n = 1,005, 26.55%, 95% confidence interval [CI] 25.15–27.99), dermatophytosis (228, 6.02%, 95% CI 5.29–6.83) and corneal ulceration (189, 4.99%, 95% CI 4.32–5.74). Among the 30 most common disorders, females showed predisposition for 3 disorders and males showed predisposition for 5 disorders. The disorder with the youngest age of affected animals was dermatophytosis (1.11 years) while weight loss had the oldest age of affected animals (4.64 years). From 757 recorded deaths, the median age at death overall was 4.03 years (IQR 2.56–5.44, range 0.17–10.00). Among deaths with a recorded cause, the most common causes of death were anorexia (n = 82, 13.87%, 95% CI 11.19–16.93), collapsed (58, 9.81%, 95% CI 7.54–12.50) and peri-anaesthetic death (20, 3.38%, 95% CI 2.08–5.18). Conclusions These results can assist veterinarians and owners by providing demographic, disorder and mortality benchmarks that support improved clinical care and welfare outcomes in guinea pigs. Many common disorders in guinea pigs were husbandry related.

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Section: Discussionsupporting

confidence: 87%

Demography, commonly diagnosed disorders and mortality of guinea pigs under primary veterinary care in the UK in 2019—A VetCompass study

O’Neill,

Taffinder,

Brodbelt

et al. 2024

PLoS ONE

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“…Ectopic endometrium was not observed. Endometrial polyp has been described not only in humans but also in chimpanzees, 10 dogs, 18,29 cats, 18,29 , horses, 22 elephants, 2 African wild dog, 12 rock hyrax, 23 mice, 45 guinea pigs, 30,55 fat sand rats, 15 and hedgehogs. 41 Clinical and pathological features of endometrial polyp have been well studied in the dog and cat.…”

Section: Discussionmentioning

confidence: 99%

Proliferative Lesions of the Endometrium of 50 Four-Toed Hedgehogs (Atelerix albiventris)

et al. 2018

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Uteri from 50 four-toed hedgehogs ( Atelerix albiventris) with clinical signs of uterine disease were histopathologically examined. Sixteen animals (32%) were diagnosed with endometrial hyperplasia, 7 animals (14%) were diagnosed with endometrial polyp, and 27 animals (54%) were diagnosed with endometrial neoplasia. The mean ages of the animals with endometrial hyperplasia, polyp, and neoplasia were 28.7 months, 29.4 months, and 25.2 months, respectively. The neoplasms were classified into 7 endometrial mixed tumors, 12 endometrial stromal nodules, and 8 endometrial stromal sarcomas. However, the endometrial stromal nodules and endometrial stromal sarcomas often developed within or were contiguous with an endometrial polyp or mixed tumor. Interestingly, the stromal tumors and the stromal components of the endometrial polyp and mixed tumor displayed extraendometrial differentiation (eg, into adipocytes, granular cells, smooth muscle cells, and osteoid tissue). The endometrial stromal sarcomas exhibited severe cellular atypia and invaded subendometrial tissue. Immunohistochemical examinations demonstrated that the stromal cells of the hyperplastic lesions as well as the neoplastic lesions were positive for CD10, the progesterone receptor, and Wilms tumor 1. The four-toed hedgehog develops unique uterine neoplasms that are mainly composed of endometrial stromal cells and probably arise from endometrial polyps and/or mixed tumors.

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“… 20 Prevalence of uterine leiomyosarcoma in guinea pigs ranges from reports of 5 of 62 uterine neoplasms 2 to 9 of 83 uterine proliferative lesions. 12 Two uterine leiomyosarcomas were also reported in a case series of 18 reproductive neoplasms in guinea pigs of both sexes, although reproductive neoplasia comprised only 18 of 341 neoplasia cases in that study. 16 Thus, the incidence of uterine leiomyosarcoma in the closest relative of the capybara is also low.…”

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confidence: 74%

Leiomyosarcoma with widespread metastases in a capybara

2022

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A 10.5-y-old intact female capybara ( Hydrochoerus hydrochaeris) with a history of chronic weight loss was euthanized following discovery by palpation of a large intra-abdominal mass. Postmortem examination revealed a large, firm, tan mass expanding the uterine body and extensively adhered to the jejunum and abdominal wall. Numerous pinpoint to 3-cm diameter, tan-to-red, raised masses were present throughout the parietal peritoneum, liver, lungs, and intestinal serosa. Histologic examination of the uterine mass revealed well-differentiated smooth muscle intermixed with abundant collagen, interspersed with a highly anaplastic spindle cell population extending to the serosa; the masses in the lung, liver, and peritoneum were histologically very similar to the anaplastic uterine spindle cells. Immunohistochemical staining of the uterus and lung confirmed smooth muscle origin of the anaplastic cells. To our knowledge, leiomyosarcoma has not been reported previously in a capybara, and the widespread metastases in this case represent an unusually aggressive presentation of this rare malignancy. The animal also had an incidental dermal histiocytoma, a tumor that has also not been reported previously in this species, to our knowledge.

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Spontaneously Arising Tumours and Tumour-like Lesions of the Cervix and Uterus in 83 Pet Guinea Pigs ( Cavia porcellus )

Cited by 12 publications

References 24 publications

Demography, commonly diagnosed disorders and mortality of guinea pigs under primary veterinary care in the UK in 2019—A VetCompass study

Demography, commonly diagnosed disorders and mortality of guinea pigs under primary veterinary care in the UK in 2019—A VetCompass study

Proliferative Lesions of the Endometrium of 50 Four-Toed Hedgehogs (Atelerix albiventris)

Leiomyosarcoma with widespread metastases in a capybara

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