Spontaneously hypertensive rat as a model of vascular brain disorder: Microanatomy, neurochemistry and behavior

Tayebati, Seyed Khosrow; Tomassoni, Daniele; Amenta, Francesco

doi:10.1016/j.jns.2012.05.047

Cited by 64 publications

(52 citation statements)

References 133 publications

(168 reference statements)

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“…(Jiwa et al 2010;Joutel et al 2010). The hippocampus was significantly smaller, specifically the density of the CA1 nuclei, in 6-month-old SHR compared to normotensive controls (Tayebti et al 2012).…”

Section: Cerebral Small Vessel Disease Modelmentioning

confidence: 83%

Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Gooch

Wilcock

2016

Cell Mol Neurobiol

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Although SHRSP develop severe hypertension, milder chronic hypertension is induced by supplementing drinking water with the NOS-inhibitor L-N-Nitroarginine methyl ester, 39 or chronic infusion of angiotensin II by minipump. 40 Mice receiving a subpressor infusion of angiotensin II develop mild hypertension (mean arterial blood pressure 90 mm Hg, relative to 70 mm Hg in saline-infused controls). 40 In addition to vascular actions, subpressor concentrations of the hyper-tensive agent may have direct effects on neural organization and metabolism. Hyperhomocysteinemia in Mice and Rats Elevated plasma concentration of the nonessential amino acid homocysteine, termed hyperhomocysteinemia, is a risk factor for VCID. 41 In wild-type mice, a diet deficient in 3 B vitamins (B6, B9-folate, and B12) resulted in hyperhomocysteinemia within 10 weeks, accompanied by reduced capillary density in brain tissue and impaired performance in Morris water maze.

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Section: Cerebral Small Vessel Disease Modelmentioning

confidence: 83%

Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Gooch

Wilcock

2016

Cell Mol Neurobiol

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“…In fact, it could be considered as a free radical generating source (14) and, therefore, SHR can be used as an animal model of oxidative stress. Hypertension-dependent organ damage was demonstrated (13,(15)(16)(17). These studies have shown that different organs of SHR (e.g., kidney, heart and brain), undergo to hypertension-related ROS-depended damage (18).…”

Section: Introductionmentioning

confidence: 96%

Effect of treatment with the antioxidant alpha-lipoic (thioctic) acid on heart and kidney microvasculature in spontaneously hypertensive rats

Tayebati

Tomassoni

Mannelli

et al. 2015

Clinical and Experimental Hypertension

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Endothelial cells represent an important vascular site of signaling and development of damage during ischemia, inflammation and other pathological conditions. Excessive reactive oxygen species production causes pathological activation of endothelium including exposure of cell to adhesion molecules. Intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and platelet-endothelial cell adhesion molecule-1 (PECAM-1) are members of the immunoglobulin super-family which are present on the surface of endothelial cells. These molecules represent important markers of endothelial inflammation. The present study was designed to investigate, with immunochemical and immunohistochemical techniques, the effect of treatment with (+/À)-alpha lipoic (thioctic) acid and its enantiomers on heart and kidney endothelium in spontaneously hypertensive rats (SHR). Arterial hypertension is accompanied by an increased oxidative stress status in the heart characterized by thiobarbituric acid reactive substances (TBARS) and nucleic acid oxidation increase. The higher oxidative stress also modifies adhesion molecules expression. In the heart VCAM-1, which was higher than ICAM-1 and PECAM-1, was increased in SHR. ICAM-1, VCAM-1 and PECAM-1 expression was significantly greater in the renal endothelium of SHR. (+/À)-Alpha lipoic acid and (+)-alpha lipoic acid treatment significantly decreased TBARS levels, the nucleic acid oxidation and prevented adhesion molecules expression in cardiac and renal vascular endothelium. These data suggest that endothelial molecules may be used for studying the mechanisms of vascular injury on target organs of hypertension. The effects observed after treatment with (+)-alpha lipoic acid could open new perspectives for countering heart and kidney microvascular injury which represent a common feature in hypertensive end-organs damage.

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“…The spontaneously hypertensive rat (SHR) is probably the model more widely investigated. It is characterized by arterial hypertension, increased oxidative stress, and overproduction of ROS [22]. Hence, SHR can be used as an animal model of oxidative stress and for investigating the activity of antioxidants.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury

Tomassoni

Amenta

Mannelli

et al. 2013

BioMed Research International

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Peripheral neuropathies are heterogeneous disorders presenting often with hyperalgesia and allodynia. This study has assessed if chronic constriction injury (CCI) of sciatic nerve is accompanied by increased oxidative stress and central nervous system (CNS) changes and if these changes are sensitive to treatment with thioctic acid. Thioctic acid is a naturally occurring antioxidant existing in two optical isomers (+)- and (−)-thioctic acid and in the racemic form. It has been proposed for treating disorders associated with increased oxidative stress. Sciatic nerve CCI was made in spontaneously hypertensive rats (SHRs) and in normotensive reference cohorts. Rats were untreated or treated intraperitoneally for 14 days with (+/−)-, (+)-, or (−)-thioctic acid. Oxidative stress, astrogliosis, myelin sheets status, and neuronal injury in motor and sensory cerebrocortical areas were assessed. Increase of oxidative stress markers, astrogliosis, and neuronal damage accompanied by a decreased expression of neurofilament were observed in SHR. This phenomenon was more pronounced after CCI. Thioctic acid countered astrogliosis and neuronal damage, (+)-thioctic acid being more active than (+/−)- or (−)-enantiomers. These findings suggest a neuroprotective activity of thioctic acid on CNS lesions consequent to CCI and that the compound may represent a therapeutic option for entrapment neuropathies.

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Spontaneously hypertensive rat as a model of vascular brain disorder: Microanatomy, neurochemistry and behavior

Cited by 64 publications

References 133 publications

Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Animal Models of Vascular Cognitive Impairment and Dementia (VCID)

Effect of treatment with the antioxidant alpha-lipoic (thioctic) acid on heart and kidney microvasculature in spontaneously hypertensive rats

Neuroprotective Activity of Thioctic Acid in Central Nervous System Lesions Consequent to Peripheral Nerve Injury

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