Spontaneously Improving Michelin Tire Baby Syndrome

Abstract

Michelin tire syndrome is described in a 22-month-old girl of Indian origin who had generalized folding of the skin, esotropia, epicanthic folds, and delayed speech. Histopathology showed diffuse lipomatous hypertrophy. The skin changes showed partial improvement on follow-up. We report this case because of its rarity. Furthermore, the spontaneous improvement is significant, unlike the persistent course of other congenital nevi.

Self-healing congenital generalized skin creases: Michelin tire baby syndrome

“…[1][2][3] Normal skin histopathology, as in our case, is also reported. 4 Reports of familial occurrence suggest that MTBS is an autosomal dominant disorder, 4,5 but it may also occur sporadically.…”

“…3 Mental retardation and developmental delay are reported in a few MTBS patients. 2 These associations were different in each case. In our MTBS pedigree, a cleft palate was observed only in the fourth generation.…”

“…4 Reports of familial occurrence suggest that MTBS is an autosomal dominant disorder, 4,5 but it may also occur sporadically. 2 It is unclear if cases of MTBS with differing histopathologic features, genetic backgrounds, or associated anomalies …”

New Described Dermatological Disorders

“…The pathophysiology of these skin creases is not clear. It may result from a variety of underlying abnormalities including nevus lipomatosus, smooth muscle hamartoma, fragmented elastic fibers with smooth muscle hamartoma or the skin may be normal histopathologically [2–5]. …”

Familial michelin tire baby syndrome

“…have reported a case of spontaneously improving MTBS. [12] Palit et al . have reported a second case of MTBS from India.…”