Sporadic Cajal cell hyperplasia is common in resection specimens for distal oesophageal carcinoma

Agaimy, Abbas; Wünsch, Peter H.

doi:10.1007/s00428-005-0117-x

Cited by 37 publications

(25 citation statements)

References 32 publications

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“…94 These lesions have been variably designated as sporadic Cajal cell hyperplasia, microscopic GISTs, GIST tumorlets, or ''seedling'' GISTs. [95][96][97][98] Although nearly 85% of incidental microscopic lesions harbor KIT mutations, based on statistics, only a small proportion (,1%) progress to clinically significant GISTs. Therefore, these microscopic lesions require additional genetic events to transform into clinically significant neoplasms.…”

Section: Do Gists Arise From Precursor Lesions?mentioning

confidence: 99%

Gastrointestinal Stromal Tumor: Advances in Diagnosis and Management

Patil

Rubin²

2011

Archives of Pathology &Amp; Laboratory Medicine

109

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Context.—Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract and should be differentiated from other mesenchymal tumors. They harbor specific activating mutations in the KIT or platelet-derived growth factor receptor α (PDGFRA) receptor tyrosine kinases, which makes them responsive to pharmacologic inhibitors, such as imatinib mesylate and sunitinib malate. Objectives.—To provide a comprehensive review of the pathogenesis of GIST and the underlying principles of targeted therapy, to review the salient histologic and immunohistochemical features that facilitate the distinction of GIST from other mesenchymal neoplasms of the gastrointestinal tract, and to present the prognostic parameters for risk stratification that guide clinical management. Data Sources.—Review of the English literature through PubMed as well as personal experience. Photographs were taken from cases encountered at the Cleveland Clinic. Conclusions.—The discovery of the KIT-GIST connection has not only improved the diagnostic accuracy of GISTs but also provided us with a better understanding of the histogenesis and molecular pathogenesis of these neoplasms.

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Section: Do Gists Arise From Precursor Lesions?mentioning

confidence: 99%

Gastrointestinal Stromal Tumor: Advances in Diagnosis and Management

Patil

Rubin²

2011

Archives of Pathology &Amp; Laboratory Medicine

109

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“…16 Two re cent stu di es ha ve fo cu sed on spo ra dic in ters ti ti al cell of Ca jal (ICC) hyperp la si a and so-cal led mi nu te scle ro sing stromal tu mors or GIST tu mo ur lets of the sto mach, res pec ti vely. 17 In our se ri es only fi ve GISTs no du les we re gre a ter than 3 cm (12.8%) and lo ca lized pre do mi nantly in the small in tes ti ne. The ICC hyperp la si a and mi nu te scle ro sing tu mors ha ve been fo und in gas tric re sec ti on spe ci men in ca se 2.…”

Section: Discussionmentioning

confidence: 61%

Multiple Gastrointestinal Stromal Tumors and Their Association with Other Rare Tumors: Case Report

Soyuer¹,

Taşdemi̇r²,

Öztürk³

et al. 2010

Turkiye Klinikleri J Med Sci

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astrointestinal stromal tumors (GISTs) are mesenchymal tumors that arise throughout the gastrointestinal tract and, rarely, in the mesentery or retroperitroneum. They are characterized by strong immunohistochemical staining for CD117 and most contain activating mutations in the KIT receptor thyrosine kinase, particularly at exons 9,11,13 and 17.1,2 Approximately one-third of tumors that are wild type at the KIT gene harbor mutations in the juxtamembrane and thyrosine kinase domains of a related thyrosine kinase receptor, platelet-derived growth factor reTurkiye Klinikleri J Med Sci 2010;30(1) 361Multiple Gastrointestinal Stromal Tumors and Their Association with Other Rare Tumors: Case Report A AB BS S T TR RA AC CT T We iden ti fi ed fo ur pa ti ents with mul tip le gas tro in tes ti nal stro mal tu mors (GIST) in small bo wel. Thre e of the adult pa ti ents ha ve ne u ro fib ro ma to sis type 1 (NF1) and one pa ti ent ha ve ne it her NF1 nor any ot her fa mi li al di sor der. Im mu nos ta ins for CD117, CD34, des min, ac tins, S-100 pro te in, and ke ra tins we re per for med on all of the tu mors. Pa ti ent's ages/gen ders we re 65/F, 66/M, 36/M and 65/F. All of the pa ti ents had mul tip le GISTs in small bo wel; at le ast thre e no du les at the si ze of ave ra ge 3.0 cm (0.2 mm-12 cm). The first pa ti ent had in ci den tal so ma tos ta ti no ma in am pulla va tery at the sa me ti me, and the se cond one had synchro no usly ade nom yo ma in am pul la va tery and gas tric ade no car ci no ma me tac hro no usly, third one was fo und in ci den tally du ring his in va gi nati on ope ra ti on and the fo urth one had gas tro in tes ti nal stro mal tu mor me tas ta sis in li ver and had thyro id pa pil lary car ci no ma (TPC) twenty ye ars be fo re. GISTs may pre sent with ot her ra re tu mors.K Ke ey y W Wo or rd ds s: : Gas tro in tes ti nal stro mal tu mors; ne op lasms, mul tip le pri mary; ne u ro fib ro ma to sis 1 Ö ÖZ ZE ET T İnce bar sak bas kın Gas tro in tes ti nal stro mal tü mör le ri (GİST) olan 4 eriş kin has ta su nul makta dır. Has ta la rın 3'ün de Nö ro fib ro ma to zis Tip 1 (NF1) bu lun mak ta iken di ğer has ta da NF1 ve ya her han gi bir ai le sel has ta lık mev cut de ğil di. Tüm has ta la ra ait tü mör ler de im mu no his to kim ya sal ola rak CD117, CD34, dez min, ak tin, S-100 pro te in ve ke ra tin ça lı şıl dı. Has ta la rın yaş la rı ve cin siyet le ri 65/K, 66/E, 36/E ve 65/K şek lin dey di. Mul tip le GİST has ta la rı mı zın tü mün de in ce bar sak yer le şim li çok sa yı da or ta la ma 3.0 cm (0.2 mm-12 cm) çap ta ol mak üze re en az 3 no dül bu lun maktay dı. İlk has ta mız ay nı za man da rast lan tı sal ola rak am pul la va te ri böl ge si ne yer leş miş so ma tos tati no ma ya, ikin ci has ta mız yi ne am pul la va te ri de ade nom yo ma ya ve fark lı za man da gas tric ade no kar si no ma ya sa hip ti. Üçün cü has ta mız da in va gi nas yon ope ras yo nu sı ra sın da te sa dü fen multip le GİST tes pit edil di. Ay nı za man da ka ra ci ğer me tas taz la rı da olan son has ta ...

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“…Similar cases of ICC hyperplasia were in elderly patients with signs and symptoms of illeus, mechanical illeus , adhesion bands, Adenocarcinoma of colon (12) and in surgical or autopsy samples of GISTs or non GISTs lesions (3,5,6), but these were not congenital or had significant manifestations of constipation for a long time. Associated diseases or disorders with ICC's anomaly are very different, such as Hirschsprung's disease (13) allied Hirschsprung's disease (14) infantile pyloric stenosis (15) and chronic idiopathic intestinal pseudo-obstruction (16), most of them can be presented with constipation but their manifestations and managements are different.…”

Section: Discussionmentioning

confidence: 94%

“…ICCs are CD117-positive CD34-expressing slender bipolar mesenchymal cells that form a network surrounding the autonomic nerves of the Auerbach plexus and are also distributed within the internal and external layer of the muscularis propria (4). The term ICC hyperplasia has been applied to a variety of microscopic CD117-expressing spindle cell lesions founded incidentally in surgical or autopsy specimens harboring larger GISTs or other non-GIST lesions (3,5,6). ICC hyperplasia may either occur as a sporadic (incidental) lesion or present in a syndromic situation known to multiple GIST tumors at different locations.…”

Section: Introductionmentioning

confidence: 99%

Sporadic Congenital Hyperplasia of Interstitial Cell of Cajal of Rectum as a Cause of Chronic Constipation

et al. 2013

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A B S T R A C TGastrointestinal stromal tumors (GIST) are the usual primary mesenchymal neoplasms of the GI tract. Interstitial cells of Cajal (ICCs) are intestinal pacemaker cells that instigate peristalsis in the stomach and intestine, and are measured to be precursors of GIST. We are reporting a 17 year old boy with chronic constipation since childhood and a huge rectum in abdominal radiography, who underwent exploratory laparotomy, resection of huge rectum and construction of sigmoid colostomy. Pathology report was "Hyperplasia of Interstitial Cells of Cajal".

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Sporadic Cajal cell hyperplasia is common in resection specimens for distal oesophageal carcinoma

Cited by 37 publications

References 32 publications

Gastrointestinal Stromal Tumor: Advances in Diagnosis and Management

Gastrointestinal Stromal Tumor: Advances in Diagnosis and Management

Multiple Gastrointestinal Stromal Tumors and Their Association with Other Rare Tumors: Case Report

Sporadic Congenital Hyperplasia of Interstitial Cell of Cajal of Rectum as a Cause of Chronic Constipation

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