Sporadic versus syndromic keratocysts—Can we predict treatment outcome? A review of 102 cysts

Noy, Dani; Rachmiel, Adi; Zar, Keidar; Emodi, Omri; Nagler, Rafael M.

doi:10.1111/odi.12687

Cited by 20 publications

(21 citation statements)

References 18 publications

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“…This syndrome is an autosomal dominant inherited condition that exhibit many specific features including multiple OKCs [12]. Noy et al described the recurrence rate of syndromic OKCs compared with sporadic OKCs and observed that there was a 3.4 times increased risk of developing recurrence in patients affected by Gorlin Goltz syndrome independently from the kind of treatment performed [12]. This increased tendency to relapse in syndromic lesions may represent a bias of this study influencing the results.…”

Section: Discussionmentioning

confidence: 86%

“…In our study, Carnoy's solution was used only in patients with Gorlin Goltz syndrome in which a preoperative diagnosis of odontogenic keratocyst has been done. This syndrome is an autosomal dominant inherited condition that exhibit many specific features including multiple OKCs [12]. Noy et al described the recurrence rate of syndromic OKCs compared with sporadic OKCs and observed that there was a 3.4 times increased risk of developing recurrence in patients affected by Gorlin Goltz syndrome independently from the kind of treatment performed [12].…”

Section: Discussionmentioning

confidence: 99%

“…The recurrence rate described in literature ranges between 5% and 62% [12]; this discrepancy may be related to characteristics of the lesion and the kind of treatment performed.…”

Section: Introductionmentioning

confidence: 97%

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Factors influencing the recurrence of keratocysts: monocentric study

Giovacchini

Bensi

Paradiso

et al. 2019

J Oral Med Oral Surg

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Introduction: The purpose of the study was to retrospectively analyse the recurrence rate of odontogenic keratocysts and to identify eventual features of the lesions that may influence recurrence. Material and methods: This was a retrospective study carried out for a period of 3 years. The medical records of patients treated in our institution were analysed to identify all the cases of odontogenic keratocysts. Results: A total of 16 odontogenic keratocysts were recorded. These lesions were treated with simple enucleation with or without adjuvant Carnoy's solution. The relapse occurred in 4 patients treated with simple enucleation and in none of the patients that underwent enucleation and Carnoy's solution application. The kind of treatment appeared not to influence recurrence rate at statistical analysis. Conclusions: Odontogenic keratocyst is a lesion with a locally aggressive behavior and a high tendency to relapse. This tendency of recurrence may be greater with syndromic presentation of odontogenic keratocyst, with soft tissue involvement, and with teeth proximity to the lesion. The application of Carnoy's solution may be useful to minimize recurrence rate in those odontogenic keratocysts with an aggressive clinical behavior and secondly may be used for all the other lesions treated with simple enucleation that experienced relapse.

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Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

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Factors influencing the recurrence of keratocysts: monocentric study

Giovacchini

Bensi

Paradiso

et al. 2019

J Oral Med Oral Surg

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“…Porém, foi descrito com detalhes histológicos apenas em 1970 e 1971 com as publicações de Browne. Este autor detalhou características histológicas importantes, bem como a sua alta capacidade de recidiva (Noy, Rachmiel, Zar, Emodi, & Nagler, 2017).…”

Section: Introductionunclassified

“…Sabe-se que o ceratocisto tem origem histológica dos restos celulares da lâmina dentária. Este cisto, diferentemente de outras entidades císticas, parece ter seu crescimento associado tanto a pressão osmótica como a fatores enzimáticos ligados a própria parede cística, fatos que levaram a ser considerado como uma lesão neoplásica até um passado recente (Noy, Rachmiel, Zar, Emodi, & Nagler, 2017).…”

Section: Introductionunclassified

Síndrome de gorlin-goltz – relato de caso

Jardim

Barros

Araújo

et al. 2021

RSD

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Introdução: A síndrome de Gorlin-Goltz é também denominada de síndrome do nevo basocelular ou síndrome do carcinoma nevóide de células basais. Esta é uma rara desordem hereditária autossômica dominante, causada pela mutação no gene supressor de tumor PTCH1. Relato de caso: Paciente do gênero masculino, 15 anos de idade, procurou o serviço de Cirurgia e Traumatologia Buco-Maxilo-Facial, relatando dores discretas na região retromolar direita, sendo solicitada uma ortopantomografia, notando-se a presença de 1 lesão na maxila e 2 lesões na mandíbula (esquerda e direita), todas associadas a dentes impactados. Na investigação, encontrou-se calcificação da foice cerebral, pontificação da sela túrcica, e depressões na região plantar dos pés. Foi realizada a enucleação e curetagem das lesões maxilares e remoção dos dentes impactados. Ao exame histopatológico, foi diagnosticado Ceratocisto Odontogênico. Discussão: A SGG consiste em um transtorno neurocutâneo, que se manifesta principalmente em pacientes jovens, sem predileção por gênero. Kimonis et Al (1997) determinam uma forma de diagnóstico através da presença de critérios maiores e critérios menores. No caso relatado foi encontrado três critérios maiores e um critério menor. Conclui-se, portanto, que apesar dos diversos achados para diagnóstico, o de maior relevância para o cirurgião Buco-Maxilo-Facial são os ceratocistos, tendo um alto poder de recidiva e destruição, estando presente em 70% dos casos de SGG, sendo mais frequente na mandíbula e associado a dentes inclusos. Até o momento, o diagnóstico e tratamento do caso mencionado foi satisfatório, fazendo-se necessário também um acompanhamento multiprofissional.

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Radiolucencies

MacDonald¹

2019

Oral and Maxillofacial Radiology

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Sporadic versus syndromic keratocysts—Can we predict treatment outcome? A review of 102 cysts

Abstract: Postsurgical complications may be expected in: older patients, upper jaw location, extensive lesions, and sporadic KCOT. Most KCOT recurrence is diagnosed 3 years from treatment.

Cited by 20 publications

References 18 publications

Factors influencing the recurrence of keratocysts: monocentric study

Factors influencing the recurrence of keratocysts: monocentric study

Síndrome de gorlin-goltz – relato de caso

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