Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity

Cen, Kaili; Chen, Ming; He, Minfei; Li, Zhenhao; Song, Yinjing; Liu, Pu; Jiang, Qi; Xu, Suzhen; Jia, Yunlu; Shen, Peng

doi:10.3389/fphar.2022.826716

Cited by 14 publications

(20 citation statements)

References 53 publications

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“…Speculatively, this effect may be attributed to KF1 's ability to reduce the generation of reactive oxygen species (ROS) through its antioxidation properties and inhibit the activation of the ERK signaling pathway, consequently diminishing arsenic‐induced skin damage. A recent study has shown that antioxidants actively combat cell damage by effectively reducing ROS production and preventing the activation of the ERK signaling pathway 56 . This research provides experimental evidence to enhance our understanding of KF1 's potential in the prevention and treatment of arsenic‐induced apoptosis.…”

Section: Discussionmentioning

confidence: 72%

“…A recent study has shown that antioxidants actively combat cell damage by effectively reducing ROS production and preventing the activation of the ERK signaling pathway. 56 This research provides experimental evidence to enhance our understanding of KF1's potential in the prevention and treatment of arsenic-induced apoptosis. In addition, this finding raises an important question for future research, prompting the evaluation of KF1's application value in arsenic detoxification through animal experiments or human intervention studies.…”

Section: Discussionmentioning

confidence: 94%

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Assessing the double‐edged of extracellular signal‐regulated kinase/CCAAT‐enhancer‐binding protein beta signaling pathway in arsenic‐induced skin damage and its potential foodborne interventions

Yang

et al. 2023

Environmental Toxicology

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Arsenic exposure is a major environmental public health challenge worldwide. As typical manifestations for arsenic exposure, the pathogenesis of arsenic‐induced skin lesions has not been fully elucidated, as well as the lack of effective control measures. In this study, we first determined the short‐term and high‐dose arsenic exposure can increase the apoptosis rates, while long‐term low‐dose arsenic exposure decrease the apoptosis rates. Then, the HaCaT cells with knockdown and overexpression of CCAAT‐enhancer‐binding protein β (CEBPB) and extracellular signal‐regulated kinase (ERK) were constructed. The results demonstrate that knockdown of CEBPB and ERK can reduce NaAsO2‐induced cell apoptosis by inhibiting ERK/CEBPB signaling pathway and vice versa. Further cells were treated with Kaji‐Ichigoside F1 (KF1). The results clearly show that KF1 can decrease the arsenic‐induced cell apoptosis rates and the expression of ERK/CEBPB signaling pathway‐related genes. These results provide evidence that ERK/CEBPB signaling pathway acts as a double‐edged sword in arsenic‐induced skin damage. Another interesting finding was that KF1 can alleviate arsenic‐induced skin cell apoptosis by inhibiting the ERK/CEBPB signaling pathway. This study will contribute to a deeper understanding of the mechanisms of arsenic‐induced skin cell apoptosis, and our findings will help to identify a potential food‐borne intervention in arsenic detoxification.

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Section: Discussionmentioning

confidence: 72%

Section: Discussionmentioning

confidence: 94%

Assessing the double‐edged of extracellular signal‐regulated kinase/CCAAT‐enhancer‐binding protein beta signaling pathway in arsenic‐induced skin damage and its potential foodborne interventions

Yang

et al. 2023

Environmental Toxicology

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“…Furthermore, Cen et al reported that combining Ganoderma lucidum polysaccharide with cisplatin reduced tumor growth and improved intestinal damage caused by cisplatin via inhibiting ROS-mediated ERK signaling against ovarian cancer. Besides, Ganoderma lucidum polysaccharide significantly sensitized cells to cisplatin in ovarian cancer 18 . Zhao et al showed that Ganoderma lucidum polysaccharide and cisplatin caused cell cycle arrest in the G2/M phase and caused apoptosis by activating caspase 3 and p53 up-regulation.…”

Section: Discussionmentioning

confidence: 94%

The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study

Rahimnia,

Akbari,

Yasseri

et al. 2023

Sci Rep

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Ganoderma lucidum polysaccharide is the most widely used complementary therapy in cancer. The present study aims to investigate the possible interaction between Ganoderma lucidum polysaccharide and Docetaxel (a chemotherapy drug) and the first-line medication for prostate cancer treatment (Flutamide) and sensitizing the cells to these treatments. The cytotoxic effects of Ganoderma lucidum polysaccharide in combination with Docetaxel and Flutamide on prostate cancer cells were investigated by the MTT test, Hoechst staining, and flow cytometry. In addition, the expression of genes related to apoptosis, angiogenesis, Epithelial-Mesenchymal Transition pathway (EMT), and prostate cancer biomarkers by Real-Time PCR was investigated. The results demonstrated that IC50 values for Ganoderma lucidum polysaccharide (30 μM and 20 μM), Docetaxel (10 μM and 5 μM), and Flutamide (20 μM and 12 μM) with MTT were confirmed by flow cytometry in a dose and time-dependent manner. Regarding the high efficacy of Ganoderma lucidum polysaccharide in combination with Flutamide and Docetaxel, 10 μM and 5 μM Flutamide were used instead of 20 μM and 12 μM and 5 μM and 2 μM Docetaxel was used instead of 10 μM and 5 μM in PC3 and LNCap, respectively. Moreover, for the first time, it was shown that Ganoderma lucidum polysaccharide alone and in combination with Docetaxel and Flutamide significantly augmented apoptosis, reduced cell migration and colonization, and downregulated expression of KLK2 and EMT pathway genes in both PC3 and LNCap cell line (P < 0.01). Ganoderma lucidum polysaccharide synergistically increased the effect of Docetaxel and Flutamide and increased the sensitivity of the prostate cancer cell lines to these drugs. Therefore, it may provide a new therapeutic strategy against prostate cancer.

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“…Cen et al evaluated the anticancer potential of Ganoderma lucidum against ovarian cancer. The obtained results exhibited the reactive-induced species-induced activation of the ERK pathway [ 146 ]. Thimmaraju et al studied the anti-tumor effect of polysaccharide (HUP-2) isolated from Hypsizygus ulmarius .…”

Section: Mushrooms As a Source Of Anticancer Agentsmentioning

confidence: 99%

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs

Asma

Acaröz

Imre

et al. 2022

Cancers

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Cancer is one of the major deadly diseases globally. The alarming rise in the mortality rate due to this disease attracks attention towards discovering potent anticancer agents to overcome its mortality rate. The discovery of novel and effective anticancer agents from natural sources has been the main point of interest in pharmaceutical research because of attractive natural therapeutic agents with an immense chemical diversity in species of animals, plants, and microorganisms. More than 60% of contemporary anticancer drugs, in one form or another, have originated from natural sources. Plants and microbial species are chosen based on their composition, ecology, phytochemical, and ethnopharmacological properties. Plants and their derivatives have played a significant role in producing effective anticancer agents. Some plant derivatives include vincristine, vinblastine, irinotecan, topotecan, etoposide, podophyllotoxin, and paclitaxel. Based on their particular activity, a number of other plant-derived bioactive compounds are in the clinical development phase against cancer, such as gimatecan, elomotecan, etc. Additionally, the conjugation of natural compounds with anti-cancerous drugs, or some polymeric carriers particularly targeted to epitopes on the site of interest to tumors, can generate effective targeted treatment therapies. Cognizance from such pharmaceutical research studies would yield alternative drug development strategies through natural sources which could be economical, more reliable, and safe to use.

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Sporoderm-Broken Spores of Ganoderma lucidum Sensitizes Ovarian Cancer to Cisplatin by ROS/ERK Signaling and Attenuates Chemotherapy-Related Toxicity

Cited by 14 publications

References 53 publications

Assessing the double‐edged of extracellular signal‐regulated kinase/CCAAT‐enhancer‐binding protein beta signaling pathway in arsenic‐induced skin damage and its potential foodborne interventions

Assessing the double‐edged of extracellular signal‐regulated kinase/CCAAT‐enhancer‐binding protein beta signaling pathway in arsenic‐induced skin damage and its potential foodborne interventions

The effect of Ganoderma lucidum polysaccharide extract on sensitizing prostate cancer cells to flutamide and docetaxel: an in vitro study

Natural Products/Bioactive Compounds as a Source of Anticancer Drugs

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