Sporothrix brasiliensis genotyping reveals numerous independent zoonotic introductions in Brazil

Spruijtenburg, Bram; Bombassaro, Amanda; Meijer, Eelco F. J.; Rodrigues, Alessandro; Grisolia, Maria Eduarda; Vicente, Vânia Aparecida; Queiroz‐Telles, Flávio; Meis, Jacques F.; Groot, Theun de

doi:10.1016/j.jinf.2023.02.034

Cited by 12 publications

(17 citation statements)

References 9 publications

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“…where the genetic diversity in the S. brasiliensis population observed in human and animal outbreaks suggests independent introductions of the species over time. 58,61 These data reinforce the results observed in the study. The…”

Section: Discussionsupporting

confidence: 89%

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Emergence of zoonotic sporotrichosis due to Sporothrix brasiliensis in Minas Gerais, Brazil: A molecular approach to the current animal disease

Colombo

Bicalho

Oliveira

et al. 2023

Mycoses

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Sporotrichosis is a neglected fungal zoonosis with significant impacts on human and animal health. Accurate diagnosis, treatment, and understanding of the transmission dynamics of Sporothrix species are essential for mitigating the spread of sporotrichosis. This study aimed to identify the Sporothrix species involved in the ongoing outbreaks of animal sporotrichosis in the metropolitan region of Belo Horizonte, Minas Gerais, Brazil, and analyse the phylogenetic relationships between pathogenic species to investigate the outbreak origin. Additionally, to better understand the evolution of the disease, we conducted a retrospective survey of positive feline and canine cases from November 2017 to July 2021 with proven cultures for Sporothrix. A significant increase in animal cases over the last 4 years was observed, with cats being the most affected host. Sporothrix brasiliensis was the predominant agent in 100% of the clinical isolates (n = 180) molecularly identified. Phylogenetic and haplotype analysis points towards the cases isolated from Minas Gerais sharing the haplotype originating from a long‐lasting outbreak of cat‐transmitted sporotrichosis in Rio de Janeiro, however, with a secondary contribution from genotypes circulating in other outbreaks in Brazil. Thus, we present clear evidence of the circulation of different S. brasiliensis genotypes associated with animal sporotrichosis in the metropolitan region of Belo Horizonte. Genetic monitoring can contribute to understanding the causal agent for zoonotic sporotrichosis in epidemiological processes and help to implement disease prevention and control measures.

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Section: Discussionsupporting

confidence: 89%

“…Similar events were seen in Curitiba, where the genetic diversity in the S . brasiliensis population observed in human and animal outbreaks suggests independent introductions of the species over time 58,61 …”

Section: Discussionmentioning

confidence: 96%

Emergence of zoonotic sporotrichosis due to Sporothrix brasiliensis in Minas Gerais, Brazil: A molecular approach to the current animal disease

Colombo

Bicalho

Oliveira

et al. 2023

Mycoses

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“…Furthermore, AFLP genotyping demonstrated that the human and feline isolates did not cluster separately, suggesting probable zoonotic transmission from infected cats. This was also recently shown with microsatellite genotyping (REF) 42 . AFLP is an easily executable method with low costs, while drawbacks of this method include reproducibility and discriminatory power.…”

Section: Discussionmentioning

confidence: 77%

“…This was also recently shown with microsatellite genotyping (REF). 42 AFLP is an easily executable method with low costs, while drawbacks of this method include reproducibility and discriminatory power. Moreover, it has to be noted that selective bases influence AFLP-generated fingerprints.…”

Section: Discussionmentioning

confidence: 99%

Genotyping and antifungal susceptibility testing of Sporothrix brasiliensis isolates from Southern Brazil

Bombassaro

Spruijtenburg

Medeiros

et al. 2023

Mycoses

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“…Instead, atypical cases can occur from the beginning of S. brasiliensis reports, which can be attributed to fungi strain characteristics, considering that they exhibit distinct virulence profiles and genotypes [94,95]. In fact, it has been demonstrated that at least seven genotypes of S. brasiliensis are currently circulating in the Brazilian territory [95,96] and that these different genotypes can vary in terms of virulence profiles and susceptibility to antifungal drugs. Considering the incidence of different clinical patterns in distinct Brazilian states, which can be associated with the genotypes and the evolution of fungi from different environmental conditions, in addition to the well-known importance of cats on the sporotrichosis epidemiological chain, a One Health approach is necessary together with the investigation of clinical patterns in humans and distinct genotypes of S. brasiliensis to clarify these points.…”

Section: Discussionmentioning

confidence: 99%

Sporothrix brasiliensis Causing Atypical Sporotrichosis in Brazil: A Systematic Review

Poester,

Xavier,

Munhoz

et al. 2024

JoF

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Zoonotic sporotrichosis, a subcutaneous mycosis caused by Sporothrix brasiliensis, has become hyperendemic and a serious public health issue in Brazil and an emerging disease throughout the world. Typical sporotrichosis is defined as fixed or lymphocutaneous lesion development, however, reports of atypical presentations have been described in hyperendemic areas, which may result in a worse prognosis. Thus, considering an increase in atypical cases and in more severe extracutaneous cases and hospitalizations reported in Brazil, we aimed to perform a systematic review to search for hypersensitivity reactions (HRs) and extracutaneous presentations associated with zoonotic sporotrichosis. A systematic review was performed, following the PRISMA guidelines to search for atypical/extracutaneous cases (mucosal, osteoarthritis, HRs, pulmonary, meningeal) of zoonotic sporotrichosis. A total of 791 published cases over 26 years (1998–2023) in eleven Brazilian states were reviewed. Most cases corresponded to a HR (47%; n = 370), followed by mucosal (32%; n = 256), multifocal (8%; n = 60), osteoarthritis (7%; n = 59), meningeal (4%; n = 32), and pulmonary (2%; n = 14) infections. When available (n = 607), the outcome was death in 7% (n = 43) of cases. Here, we show a frequent and worrisome scenario of zoonotic sporotrichosis in Brazil, with a high and dispersed incidence of atypical/extracutaneous cases throughout the Brazilian territory. Therefore, educational measures are necessary to make health professionals and the overall population aware of this fungal pathogen in Brazil as well as in other countries in the Americas.

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Sporothrix brasiliensis genotyping reveals numerous independent zoonotic introductions in Brazil

Cited by 12 publications

References 9 publications

Emergence of zoonotic sporotrichosis due to Sporothrix brasiliensis in Minas Gerais, Brazil: A molecular approach to the current animal disease

Emergence of zoonotic sporotrichosis due to Sporothrix brasiliensis in Minas Gerais, Brazil: A molecular approach to the current animal disease

Genotyping and antifungal susceptibility testing of Sporothrix brasiliensis isolates from Southern Brazil

Sporothrix brasiliensis Causing Atypical Sporotrichosis in Brazil: A Systematic Review

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