Sporotrichosis

Lurie, H. I.

doi:10.1007/978-3-662-12027-9_14

Cited by 4 publications

(1 citation statement)

References 95 publications

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“…In any case, it is well known that there is considerable variation in individual response to fungal infections. Spontaneous healing of cutaneous lesions in human cases of sporotrichosis has been reported previously [3,6]. The frequency of spontaneous healing in sporotrichosis may be more common than is realized because positive skin tests to Sporothrix yeast cell antigen may be present in persons with no reported history of previous infection [5, 6, 101 . In humans, clinical reports show that disseminated sporotrichosis and sporothrix arthritis were diagnosed mostly in persons with some form of compromised immune defenses.…”

Section: Discussionmentioning

confidence: 97%

Reappearance ofSporothrix schenckiilesions after administration of Solu-Medrol^Rto infected cats

1980

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In 10 of 34 adult cats infected with Sporothrix schenckii, demonstrable lesions healed spontaneously in 31 to 88 days after inoculation of the organism. None of 5 untreated cats developed additional visible lesions during the period of observation, nor were they positive for S. schenckii by culture at necropsy. Five animals were treated with Solu-Medrol R to determine if the apparent clinical cure was also accompanied by a mycological cure. Lesions reappeared at, or near, the site of the original lesions in 3 of the 5 treated cats from 4 to 6 months after the initial lesions healed. Fungi were cultured both from the regional lymph node and from exudate of the skin lesions. Thus, it appears that viable S. schenckii may be sequestered in tissues for at least 6 months without showing clinical evidence of their presence. Moreover, apparently "healed" lesions may be reactivated and progress to typical demonstrable skin lesions following immuno-suppression.Previous work in our laboratory [1,2] has demonstrated that the domestic cat can be used as an experimental host to study various aspects of sporotrichosis. As part of a larger study to test the effects of various drugs on skin lesions produced by Sporothrix schenckii, 34 cats were infected with S. schenckii and all showed demonstrable lesions. In 10 of these animals, lesions healed spontaneously without medication. In an effort to determine if this apparent clinical cure was also a mycological one, 5 cats were given a course of methyl-predisolone sodium succinate (Solu-Medrol R) to suppress immune responses. This report documents the response observed in these animals following administration of the drug. MATERIAL AND METHODS FungusThe organism used in this study was the Fossler strain ATCC 14804 originally isolated from a typical lymphatic lesion on the arm of an adult male in 1960. Yeast phase cells were used for inoculation and were grown for 10-14 days on modified Kelley's media agar slants at 37 °C [13]. They were harvested by washing them from the agar slants with sterile buffered saline. This buffer was also used to wash the cells twice and to suspend them at the desired concentration. Experimental animalsAdult domestic cats of either sex and of varied background were immunized against feline distemper and pneumonitis before use in this experiment. All animals were maintained in individual cages in the same room and were examined regularly

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Section: Discussionmentioning

confidence: 97%

Reappearance ofSporothrix schenckiilesions after administration of Solu-Medrol^Rto infected cats

1980

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Spontaneous feline sporotrichosis: A fine structural study

et al. 1979

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Fine structural details of the parasitic yeastlike phase of Sporothrix schenckii contained in biopsy tissue from a naturally-occurring case of disseminated feline sporotrichosis are described and illustrated by electron microscopy. Both free and phagocytosed fungal cells were observed. The fungal cells were contained within an extracellular, electron transparent vacuolar area which was bounded by a limiting membrane of probable host origin. The yeastlike cells were characterized by a conspicuous layer of osmiophilic microfilaments which occurred along the outermost surface of the cell wall. In many yeastlike cells, scattered, membrane-bound vacuoles containing electron opaque material were observed in the cytoplasm. Asteroid bodies were not observed.

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Epidemiology of sporotrichosis in Venezuela

et al. 2013

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Sporotrichosis is an endemic subcutaneous mycosis in Venezuela. There are no reports to this date of disseminated forms of the disease, even amongst patients with acquired immunodeficiency syndrome. Direct microscopic examination of wet mount slides with saline solution or distilled water in the search for asteroid bodies is paramount. Saturated sodium and potassium iodine solutions continue to be extremely efficacious and affordable to most of our patients, therefore our treatment of choice.

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Sporotrichosis

Cited by 4 publications

References 95 publications

Reappearance ofSporothrix schenckiilesions after administration of Solu-Medrol^Rto infected cats

Reappearance ofSporothrix schenckiilesions after administration of Solu-Medrol^Rto infected cats

Spontaneous feline sporotrichosis: A fine structural study

Epidemiology of sporotrichosis in Venezuela

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Sporotrichosis

Cited by 4 publications

References 95 publications

Reappearance ofSporothrix schenckiilesions after administration of Solu-MedrolRto infected cats

Reappearance ofSporothrix schenckiilesions after administration of Solu-MedrolRto infected cats

Spontaneous feline sporotrichosis: A fine structural study

Epidemiology of sporotrichosis in Venezuela

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Reappearance ofSporothrix schenckiilesions after administration of Solu-Medrol^Rto infected cats

Reappearance ofSporothrix schenckiilesions after administration of Solu-Medrol^Rto infected cats