Sporting Activity Is Reduced 11 Years After First-Generation Autologous Chondrocyte Implantation in the Knee Joint

Erdle, Benjamin; Herrmann, Simon; Porichis, Stella; Uhl, Markus; Ghanem, Nadir; Schmal, Hagen; Suedkamp, Norbert P.; Niemeyer, Philipp; Salzmann, Gian M.

doi:10.1177/0363546517716920

Cited by 7 publications

(8 citation statements)

References 54 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Postoperative sports activity also showed impressive results and demonstrated significant (p < 0.05) correlation with all clinical outcome parameters. These results are in line with previous findings, which also reported significant correlations between pre-and postoperative sports activity and clinical outcome after ACI and microfracture [12,14,23]. All these results suggest that the preoperative performance level is an important indicator of the clinical outcome.…”

Section: Discussionsupporting

confidence: 92%

“…It is therefore possible that based on the surgery result alone, an even higher postoperative sporting level could be achieved. Similar observations have already been made in earlier studies with first-generation ACI [14]. All clinical scores showed highly significant improvements for the considered patient cohort with an average of 8 years (5-14) after third-generation ACI (p < 0.001).…”

Section: Discussionsupporting

confidence: 89%

See 1 more Smart Citation

Third generation autologous chondrocyte implantation is a good treatment option for athletic persons

Niethammer

Altmann

Holzgruber

et al. 2020

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

Purpose Autologous chondrocyte implantation is an established method for the treatment of joint cartilage damage. However, to date it has not been established that autologous chondrocyte implantation is an appropriate procedure for cartilage defects therapy in athletic persons. The aim of this study is to analyze if third-generation autologous chondrocyte implantation is an appropriate treatment for athletic persons with full cartilage defect of the knee joints. Methods A total of 84 patients were treated with third-generation autologous chondrocyte implantation (NOVOCART ® 3D). The mean follow-up time was 8 years (5-14). Sports activity was measured via UCLA Activity Score and Tegner Activity Scale before the onset of knee pain and postoperatively in an annual clinical evaluation. 41 athletic persons and 43 non-athletic persons (UCLA-Cutoff: 7; Tegner Activity Scale-Cutoff: 4) were analyzed. Patient reported outcomes were captured using IKDC subjective, KOOS, Lysholm score and VAS score on movement. Results Patient reported outcomes (IKDC, VAS at rest, VAS on movement) showed significant improvement (p < 0.001) postoperatively. Athletic persons demonstrated significantly better results than non-athletic persons in the analyzed outcome scores (IKDC: p < 0.01, KOOS: p < 0.01, Lysholm score: p < 0.01). 96.4% of the patients were able to return to sport and over 50% returned or surpassed their preinjury sports level. The remaining patients were downgraded by a median of two points on the UCLA-and 2.5 on the Tegner Activity Scale. A shift from high-impact sports to active events and moderate or mild activities was found. Furthermore, it was shown that preoperative UCLA score and Tegner Activity Scale correlated significantly with the patient reported outcome postoperatively. Conclusion Autologous chondrocyte implantation is a suitable treatment option for athletic persons with full-thickness cartilage defects in the knee. The return to sports activity is possible, but includes a shift from high-impact sports to less strenuous activities.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 89%

Third generation autologous chondrocyte implantation is a good treatment option for athletic persons

Niethammer

Altmann

Holzgruber

et al. 2020

Knee Surg Sports Traumatol Arthrosc

View full text Add to dashboard Cite

show abstract

“…Regardless, analysis of the single treatment procedures did not result in significant correlations. Currently, evidence cannot suggest a correlation between the T2-weighted relaxation times and clinical outcomes [22]. Different scores have been introduced for qualitative assessment of the knee joint after cartilage repair.…”

Section: Discussionmentioning

confidence: 99%

Clinical and radiographical ten years long-term outcome of microfracture vs. autologous chondrocyte implantation: a matched-pair analysis

Ossendorff

Franke

Erdle

et al. 2018

International Orthopaedics (SICOT)

Self Cite

View full text Add to dashboard Cite

show abstract

“…Particularly in a community-level patient cohort (as opposed to professional athletes), a range of factors will affect post-operative activity level above and beyond ongoing knee problems, including family and work commitments, as well as other musculoskeletal and health concerns. Erdle et al 26 recently reported that the pre-morbid level of sporting and recreational activities cannot be achieved at a minimum of 10 years after first-generation chondrocyte implantation, though they did not inquire as to when patients altered their postoperative activity, nor the reasons behind this. The current study did not evaluate other factors that can contribute to post-operative activity, though these reasons for not attaining a higher activity profile must be acknowledged.…”

Section: Discussionmentioning

confidence: 99%

Post-Operative Sport Participation and Satisfaction With Return to Activity After Matrix-Induced Autologous Chondrocyte Implantation in the Knee

Ebert

Janes

Wood

2020

Intl J Sports Phys Ther

View full text Add to dashboard Cite

Background: Returning to a satisfactory activity level is expected by patients after cartilage repair, and may define overall surgical success.Purpose: To investigate: 1) the level and improvement in activity in patients at two years after matrix-induced autologous chondrocyte implantation (MACI), 2) what factors are associated with post-operative (and improvement in) activity level, and 3) whether patients are satisfied with their ability to participate in recreational and/or sporting activities. Study Design: Prospective cohort.Methods: One hundred and fifty patients that underwent MACI were included in this analysis (83 tibiofemoral and 67 patellofemoral). All patients completed the Tegner Activity Scale (TAS) and the Knee Injury and Osteoarthritis Outcome Score (KOOS) presurgery and at two years (range: 24-26 months) post-surgery, as well as a questionnaire evaluating satisfaction with their ability to return to recreational and sporting activities. Results:The TAS significantly improved (p<0.001) from 2.97 (SD 0.92, range 0-7) to 4.09 (SD 1.49, range 0-9), while the KOOS Sport significantly improved (p<0.0001) from 27.5 (SD 23.1, range 0-95) to 61.1 (SD 27.3, range 0-100). Overall, 88 patients (59%) improved ≥1 point on the TAS, while 121 patients (81%) improved ≥10 points on the KOOS Sport, previously reported as the minimal detectable change for each. Patient age, duration of symptoms (DOS) and gender were associated with post-operative activity level, though body mass index (BMI), defect size and concomitant procedures were not. Overall, 128 patients (85%) were satisfied with their ability to return to recreational activities, with 99 (66%) satisfied with sport participation. The two-year TAS, and TAS improvement, were significantly associated with satisfaction in performing recreational activities (two-year TAS, rho=-0.42, p<0.0001; TAS improvement, r=-0.33, p<0.0001) and sport participation (two-year TAS, rho=-0.49, p<0.0001; TAS improvement, r=-0.37, p<0.0001). Conclusions:The TAS and KOOS Sport significantly improved after MACI, though only 59% of patients improved ≥1 point on the TAS. Despite this, 85% and 66% of patients were satisfied with their ability to return to recreational activities and participate in sport, respectively. Age, DOS and gender were associated with activity, and overall these findings can be used to provide realistic activity expectations to patients undergoing MACI.

show abstract

Sporting Activity Is Reduced 11 Years After First-Generation Autologous Chondrocyte Implantation in the Knee Joint

Abstract: The premorbid level of sporting and recreational activities cannot be achieved 11 years after ACI-P. The MRI results determined at this time point did not conclusively correlate with long-term sporting activity.

Cited by 7 publications

References 54 publications

Third generation autologous chondrocyte implantation is a good treatment option for athletic persons

Third generation autologous chondrocyte implantation is a good treatment option for athletic persons

Clinical and radiographical ten years long-term outcome of microfracture vs. autologous chondrocyte implantation: a matched-pair analysis

Post-Operative Sport Participation and Satisfaction With Return to Activity After Matrix-Induced Autologous Chondrocyte Implantation in the Knee

Contact Info

Product

Resources

About