Spray coating of dual antibiotic-loaded nanospheres on orthopedic implant for prolonged release and enhanced antibacterial activity

Indwelling urinary catheter assembled with lidocaine‐loaded polymeric strand for local sustained alleviation of bladder discomfort

“…In previous studies, IUC has been mostly dip-coated or spray-coated with a solution of drug or a mixture of drug and polymer, which allows local and sustained drug release -- (Horprasertkij, Dwivedi, Riansuwan, Kiratisin, & Nasongkla, 2019;Park et al, 2003;Srisang & Nasongkla, 2019a, 2019bSrisang et al, 2020;Tambunlertchai, Srisang, & Nasongkla, 2017). Thus, the material of the IUC itself and/or the coated polymer serves as the drug diffusion mediator to allow for sustained drug release.…”

Antibacterial Layer-by-Layer Coatings for Medical Implants

“…Vancomycin is loaded into niosomes, which are assembled in an LbL coating formulated as follows: Vancomycin/poly(lactic acid) (PLA)/niosomes, with 40 tri-layers deposited on top of the orthopaedic implant (bone plates made from stainless steel) [ 102 ]. The same research group recently reported other coatings strategies based on niosomes containing antibiotics [ 103 , 104 ]. They have coated dental implants alternating niosomes and PLA comprising two types of niosomes, i.e., the first ones made of sorbitan stearate (span 60) and the others of cholesterol with encapsulated minocycline [ 103 ].…”

Biocompatibility and stability during storage of Foley urinary catheters coated chlorhexidine loaded nanoparticles by nanocoating: in vitro and in vivo evaluation

“…A urinary catheter is surface device and depends on the contact duration (limited, prolonged, and permanent). It must be tested to evaluate its cytotoxicity, sensitization, irritation, and hemolysis to confirm its biosafety 1‐8 . A long‐term catheterization is called an indwelling catheterization, which allows bacteria in the urinary tract try to dwell on the catheter surface and then become a biofilm, which results in infection.…”

“…It must be tested to evaluate its cytotoxicity, sensitization, irritation, and hemolysis to confirm its biosafety. [1][2][3][4][5][6][7][8] A long-term catheterization is called an indwelling catheterization, which allows bacteria in the urinary tract try to dwell on the catheter surface and then become a biofilm, which results in infection. Various reports have presented strategies to prevent biofilm formation.…”

“…For our previous studies, nanocoating via chlorhexidine-loaded nanoparticles (CHX-loaded NPs) on a urinary catheter's surface represented the reduction of biofilm formation and anti-infection in the urinary tract, which also presented no cytotoxicity with the L929 fibroblast cell. 2,[5][6][7] However, prior to the abovementioned study, it is necessary to assess the adverse toxic effects of medical devices in animal tests.…”