Spray cryotherapy for the treatment of glottic and subglottic stenosis

Krimsky, William; Rodrigues, Michael P.; Malayaman, Navara; Sarkar, Saiyad

doi:10.1002/lary.20794

Cited by 44 publications

(44 citation statements)

References 12 publications

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“…While the use of cryotherapy for esophageal cancer is relatively recent, it has been used for some time in the treatment of glottic and subglottic stenosis, radiation proctitis, and for skin conditions such as warts also. [2122]…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, cryotherapy treatment was associated with a complete eradication of Barrett's HGD in 72-100% of patients whereas early stage esophageal cancer patients, a complete response to cryotherapy treatment was observed in 61-100% of patients. [202122]…”

Section: Discussionmentioning

confidence: 99%

“…As nitrous oxide gas is released from a high pressure to a low pressure into the cryotip, the drop in temperature results in freezing of tissues which is in accordance with the fact that for cell death to occur, temperature must fall below −20°C. [2021] During the freeze cycle, the drop in temperature results in (a) crystallization of extracellular water and (b) reduction of cell resistance to shrinkage due to membrane lipid hardening. Besides, the electrolyte concentration increases with depleting stores of extracellular water.…”

Section: Discussionmentioning

confidence: 99%

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Cryotherapy for treatment of mouth mucocele

Aulakh¹,

Brar²,

Azad³

et al. 2016

Niger J Surg

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A mucocele is a common salivary gland disorder that most commonly affects young adults. A 35-year-old female patient reported to the Department of Oral and Maxillofacial Surgery, with the chief complaint of swelling on the left side of floor of mouth. The aim of this case report is to present the management of mucocele present in floor of the mouth in a young female patient using liquid nitrogen cryosurgery. The present case report has also discussed mechanism of action, current protocol of cryosurgery with emphasis on clinical pros and cons along with the clinical outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Cryotherapy for treatment of mouth mucocele

Aulakh¹,

Brar²,

Azad³

et al. 2016

Niger J Surg

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“…Due to concerns about barotrauma, it was slower to adapt this technology in the airway. Krimsky et al published a case series in 2010 where they used SCT for the treatment of three patients with glottic and subglottic stenosis which resulted in patency of the stenosed areas with some degree of normalization of the mucosa (15). In 2011 and 2012, Fernando and Finley described two multicenter studies using SCT with the first generation device in the treatment of benign and malignant airway disease.…”

Section: Brief History Of Cryotherapymentioning

confidence: 99%

Current status of spray cryotherapy for airway disease

Moore¹,

Lile²,

Abbas³

2017

J. Thorac. Dis.

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The use of liquid nitrogen to treat skin and mucosal lesions is well understood in the dermatologic and gastrointestinal literature. Direct spray cryotherapy (SCT) in the airway has shown promising results in the treatment of esophageal premalignant and even invasive lesions. In the airway, several studies have shown it to be a safe, effective treatment for both benign and malignant disease. It is easily administered in the outpatient setting and can be repeated several times without undue side effects. In this article, we review the current literature on the use of SCT for the treatment of endobronchial lesions and also describe our own institutional experience of the use of SCT in the airway. The use of proper technique and airway venting is important in mitigating the complications of barotrauma from massive expansion of nitrogen upon conversion from the liquid to gaseous state. We also review some of the basic science principals behind the use of the cryotherapy to treat lesions in different tissues. We feel that SCT is a potential area for further research at both clinical and basic science level.

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“…Therapeutic bronchoscopic modalities include balloon dilatation, laser, APC, electrocauterization, cryotherapy, stent placement, endobronchial chemotherapy and brachiotherapy [28][29][30][31]. When therapeutic bronchoscopy is compared with surgical therapy it is more comfortable and less risky for the patients [6].…”

Section: Discussionmentioning

confidence: 99%

Palliative Therapy with Argon Plasma Coagulation in Post-Intubation Tracheal Stenosis

Mertoğlu¹,

Vatansever²,

Balcı³

et al. 2012

Tur Toraks Der

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ÖZETPost-entübasyon trakeal stenozlara genellikle endotrakeal tüp "cuf" larına ait basınç nekrozları neden olmaktadır. En iyi sonuç-lar trakeal rekonstüksiyon cerrahisi ile alınmasına rağmen, medikal ya da kişisel nedenlere bağlı olarak her olguda operasyon uygulanamamaktadır. Altmış yedi yaşında erkek hasta medikal tedaviye rağmen giderek artan nefes darlığı yakınması ile hastanemize başvurdu. Bronkoskopide trakeada vokal kordların 2 cm altında stenoz saptandı. Bu olguda KOAH'a bağlı solunum yetmezliği cerrahi için kontrendikasyon oluşturuyordu. Argon Plazma Koagülasyonu (APC) ile trakeal stenozun dilatasyonuna karar verildi. Yirmi yaşında genç kadın hasta nefes darlığı ve stridor ile hastanemize başvurdu. Bronkoskopide trakeada vokal kordların 3 cm altında stenoz saptandı. Cerrahi tedaviyi reddettiği için olguda APC ile trakeal dilatasyon kararı alındı. APC cerrahi tedaviyi reddeden ve klinik olarak inoperabl olan iki hastada başarılı palyasyon sağladı. Olguların işlemden hemen sonra semptomlarında düzelme gözlendi. Seçilmiş olgularda APC endobronşial desobstrüksiyonu sağlayan etkin bir alternatif tedavi gibi görünmektedir. ( ABSTRACTPost-intubation tracheal stenosis is usually caused by pressure necrosis at the cuff. Although the best results are obtained by tracheal reconstruction, not all patients are able to undergo this operation for either medical or personal reasons. A 67-year-old male was admitted to our hospital with progressive dyspnea unrelieved by medical management. Bronchoscopy revealed stenosis of the trachea 2 cm below the vocal cord. In this case, as respiratory failure accompanied by COPD constituted a contraindication for tracheal surgery. It was decided to dilate the tracheal stenosis with APC. A 20-year-old female was admitted to our hospital with dyspnea and stridor. Bronchoscopy revealed a stenosis of the trachea 3 cm below the vocal cord. Because surgery was refused it was decided to dilate the tracheal stenosis with APC. APC has been successfully employed in the treatment of post-intubation tracheal stenosis in two surgery-refused and inoperable patients. The patients immediately experienced a relief of symptoms after APC. APC appears to be an effective alternative procedure for endobronchial dilatation in selected patients who are inoperable for either medical or personal reasons. (Turk Toraks Derg 2012; 13: 137-40)

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Spray cryotherapy for the treatment of glottic and subglottic stenosis

Abstract: The use of spray cryotherapy alone or in conjunction with balloon dilation is a promising and effective therapeutic approach to treating glottic and subglottic narrowing.

Cited by 44 publications

References 12 publications

Cryotherapy for treatment of mouth mucocele

Cryotherapy for treatment of mouth mucocele

Current status of spray cryotherapy for airway disease

Palliative Therapy with Argon Plasma Coagulation in Post-Intubation Tracheal Stenosis

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