Spray-dried chitosan microspheres cross-linked with d, l-glyceraldehyde as a potential drug delivery system: preparation and characterization

Abstract

-Chitosan microspheres of a small particle size and with good sphericity were prepared by a spraydrying method followed by treatment with a cross-linking agent. Owing to restrictions on the use of crosslinked chitosan microspheres in the pharmaceutical field, d,l-glyceraldehyde, a biocompatible reatant was used. The parameters studied affecting extent of cross-linking were cross-linking time and concentration of the cross-linking agent. Glutaraldehyde, the aldehyde most frequently employed as chemical cross-linking agent for proteins, was also used as a control. The cross-linked spray-dried chitosan microspheres were analyzed with respect to their morphological aspects, particle size, zeta potential and water uptake capacity. It was found that an increase either in d,l-glyceraldehyde concentration or in duration of cross-linking caused a decrease in both the swelling capacity and the zeta potential of the chitosan microspheres. Compared to glutaraldehyde, d,l-glyceraldehyde appears to be a good cross-linking agent for chitosan microspheres with the advantage that it is nontoxic.

Pulmonary delivery of antitubercular drugs using spray-dried lipid–polymer hybrid nanoparticles

“…Moisture content of the dry powders was checked by the Karl Fisher volumetric titration method. Th e sample (approximately 15 mg) was weighed and analyzed using Karl Fischer titrimetry for the moisture content (Oliveira et al 2005).…”

Spray-dried chitosan microspheres containing 8-hydroxyquinoline -5 sulphonic acid as a new adsorbent for Cd(II) and Zn(II) ions

“…This is mainly attributed to complexing agents which are not covalently bonded, and, consequently, the ligand is not rigidly attached to the adsorbent [8,9]. Chitosan is an excellent support, extensively used in the microencapsulation of drugs [10]. It is obtained from the partial deacetylation of chitin in concentrated alkaline solutions.…”

Surface morphology of spray-dried nanoparticle-coated microparticles designed as an oral drug delivery system

“…One of these methods, the spray drying technique, has been successfully employed in the preparation of microparticulated delivery systems (Conte et al, 1994;Blanco et al, 2003;Huang et al, 2003;Oneda and Ré, 2003;Oliveira et al, 2005). This method offers advantages such as a rapid and one-step process, applicability to heat-sensitive materials and the possibility of scaleup (Wan et al, 1992).…”