Spray Dried Products—Characterization of Particle Morphology

Walton, D.E.; Mumford, C.J.

doi:10.1205/026387699525846

Cited by 172 publications

(90 citation statements)

References 10 publications

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“…1a and b). Walton and Mumford (1999) observed similar trends for the bulk density. Kha et al (2010); Goula and Adamopoulos (2010) also observed a reduction of powders bulk density with increasing air temperatures, studying the spray drying of Gac (Momordica cochinchinensis) fruit aril powder and orange juice powders, respectively.…”

Section: Bulk Densitysupporting

confidence: 67%

Spray drying of liquorice (Glycyrrhiza glabra) extract

Karaaslan

Dalgıç

2012

J Food Sci Technol

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The objective of this work was to study the influence of spray drying conditions on the physicochemical properties of liquorice (Glycyrrhiza glabra) extract. The stickiness and hydroscopicity problems in the power were overcome by use of dextrose equivalent (DE12) and DE19 maltodextrins as drying agents. The inlet air temperatures of 110°C, 120°C, and 130°C and maltodextrin concentrations of 10 %, 15 %, and 20 % (maltodextrin dry solids/100 g feed mixture dry solids) were the independent variables. Moisture content, bulk density, color change, hygroscopicity, acidity & pH, solubility were analyzed to determine the effects of spray drying conditions. Increases in inlet air temperature were caused an increase in yield, pH, solubility and a decrease in moisture content, bulk density, hygroscopicity, L*, a*, b*, acidity. Increases in maltodextrin concentrations were caused an increase in yield, L*, b*, acidity and a decrease in moisture content, bulk density, hygroscopicity, a*, pH, solubility. Increases in DE maltodextrins were caused an increase in bulk density, hygroscopicity, L*, pH and a decrease in yield, moisture content, a*, b*, acidity, solubility.

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Section: Bulk Densitysupporting

confidence: 67%

Spray drying of liquorice (Glycyrrhiza glabra) extract

Karaaslan

Dalgıç

2012

J Food Sci Technol

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“…Consequentemente, estas partículas apresentam inicialmente um menor teor de umidade e secam mais rápido, estando assim mais passíveis de sofrerem degradação térmica. 22 O tamanho da partícula e a distribuição do tamanho das partículas influenciam nas propriedades de fluxo de um pó. Os pós podem apresentar três tipos de comportamento de fluxo: fluidez livre, semilivre e coesa.…”

Section: Distribuição Do Tamanho Das Microcápsulasunclassified

“…Entretanto, a principal consideração é o grau de aglomeração das partículas. 22 Partículas pequenas aderem-se muito mais fortemente entre si do que partículas grandes, então pós finos apresentam uma maior tendência à aglomeração. A fluidez de um pó aumenta com o aumento do tamanho da partícula.…”

Section: Distribuição Do Tamanho Das Microcápsulasunclassified

Avaliação da porosidade de microcápsulas contendo proteína bioativa por porosimetria de mercúrio e adsorção de nitrogênio

Porte¹,

Leão²,

Porte³

2011

Quím. Nova

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Recebido em 2/3/11; aceito em 27/4/11; publicado na web em 14/6/11 EVALUATION OF POROSITY OF MICROCAPSULES CONTAINING BIOCATIVE PROTEIN BY MERCURY POROSIMETRY AND NITROGEN ADSORPTION. Microcapsules containing lactoferrin were produced by spray drying using dextrin:octenylsuccinate starch, as wall materials. Porosity characteristics of spray-dried microcapsules were investigated by mercury intrusion porosimetry and nitrogen adsorption. The outer and inner structures of microcapsules were studied by Scanning Electron Microscopy and sizes were determined by Laser Diffraction. Results indicate that all microcapsules presents adsorption isotherm of type II and that micropores on the microcapsules surface will be very few or none. Our results show that microstructure, surface area and size of microcapsules are affected by dextrin: octenylsuccinate starch proportion. Pore characteristics for various microcapsules are found to be different.Keywords: porosity; microcapsules; spray drying. INTRODUÇÃOTem surgido um crescente interesse em relação às atividades fisiológicas e biológicas de algumas frações proteicas presentes no soro de leite como, por exemplo, a proteção da flora intestinal contra bactérias enteropatogênicas, proteção do organismo contra íons metálicos livres, transporte fisiológico de ferro e imunorregulação, desempenhadas ou propiciadas pela lactoferrina. Considerando as propriedades únicas que esta proteína pode conferir a determinados alimentos e a demanda atual por sistemas antimicrobianos e funcionais naturais, percebe-se a aplicação potencial da lactoferrina encapsulada na indústria de alimentos, permitindo futuramente a abertura de um novo mercado para a utilização desta proteína em alimentos industrializados.A técnica de spray drying é potencialmente adequada para encapsulação de peptídeos e proteínas por ser uma operação contínua relativamente simples e de menor custo. Contudo, durante o processo de secagem podem ocorrer diferentes graus de colapso, que determinarão a estrutura do produto final. 1A encapsulação é o processo pelo qual um material ou mistura de materiais chamados de núcleo ou material ativo são revestidos com ou contidos dentro de um outro material ou sistema, chamado de material de parede ou encapsulante. 2Para microencapsulação por spray drying, a escolha do material de parede é crítica, pois irá influenciar a estabilidade da dispersão antes da secagem e as propriedades das microcápsulas após a secagem. Os materiais encapsulantes usados consistem de uma grande variedade de polímeros formadores de filme como gomas, carboidratos, celuloses, lipídeos, proteínas e materiais inorgânicos, sendo a escolha destes dependente, dentre outros fatores, das características do núcleo. 3O amido modificado octenilsuccinato possui atividade superficial, sendo capaz de reduzir a tensão superficial de uma solução, podendo ser utilizado como um emulsificante. 4,5 Durante a produção das microcápsulas, devido à alta temperatura de secagem podem ocorrer alterações na estrutura secundária da proteína utili...

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“…EFV is currently marketed as tablets and capsules containing the drug in the crystalline form with controlled particle size. For poorly water soluble drugs, the solid state properties of the drug such as particle size, crystal structure, and physical form greatly influence their dissolution properties and also directly influence their bulk powder properties such as density and flowability (7,8). EFV is a hydrophobic drug with low density and high flow resistance (9).…”

Section: Introductionmentioning

confidence: 99%

Physicochemical Characterization of Efavirenz–Cyclodextrin Inclusion Complexes

et al. 2009

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Abstract. Efavirenz (EFV) is an oral antihuman immunodeficiency virus type 1 drug with extremely poor aqueous solubility. Thus, its gastrointestinal absorption is limited by the dissolution rate of the drug. The objective of this study was to characterize the inclusion complexes of EFV with β-cyclodextrin (β-CD), hydroxypropyl β-CD (HPβCD), and randomly methylated β-CD (RMβCD) to improve the solubility and dissolution of EFV. The inclusion complexation of EFV with cyclodextrins in the liquid state was characterized by phase solubility studies. The solid-state characterization of various EFV and CD systems was performed by X-ray diffraction, differential scanning calorimetry, and scanning electron microscopy analyses. Dissolution studies were carried out in distilled water using US Pharmacopeia dissolution rate testing equipment. Phase solubility studies provided an A L -type solubility diagram for β-CD and A P -type solubility diagram for HPβCD and RMβCD. The phase solubility data enabled calculating stability constants (K s ) for EFV-βCD, EFV-HPβCD, and EFV-RMβCD systems which were 288, 469, and 1,073 M −1 , respectively. The physical and kneaded mixtures of EFV with CDs generally provided higher dissolution of EFV as expected. The dissolution of EFV was substantially higher with HPβCD and RMβCD inclusion complexes prepared by the freeze drying method. Thus, complexation with HPβCD and RMβCD could possibly improve the dissolution rate-limited absorption of EFV.

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Spray Dried Products—Characterization of Particle Morphology

Cited by 172 publications

References 10 publications

Spray drying of liquorice (Glycyrrhiza glabra) extract

Spray drying of liquorice (Glycyrrhiza glabra) extract

Avaliação da porosidade de microcápsulas contendo proteína bioativa por porosimetria de mercúrio e adsorção de nitrogênio

Physicochemical Characterization of Efavirenz–Cyclodextrin Inclusion Complexes

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