Spread and predominance in Japan of novel G1P[8] double-reassortant rotavirus strains possessing a DS-1-like genotype constellation typical of G2P[4] strains

Fujii, Yoshiki; Nakagomi, Toyoko; Nishimura, Naoko; Noguchi, Atsuko; Miura, Sinobu; Ito, Hisato; Doan, Yen Hai; Takahashi, Tsutomu; Ozaki, Takao; Katayama, Kazuhiko; Nakagomi, Osamu

doi:10.1016/j.meegid.2014.08.001

Cited by 60 publications

(80 citation statements)

References 35 publications

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“…While the cause of such yearly variation is not known, different circulating strains are often suspected. Thus, the predominant genotype in this study (G1P [8]) was the same as that reported by Fujii et al (17). G1P [8] was detected in both regions with a nearly identical frequency: 32 (73z) of 44 rotaviruspositive specimens collected in the Yuri district and 13 (72z) of 18 rotavirus-positive specimens in the Nantan district.…”

Section: Discussionsupporting

confidence: 89%

Regional Variations in the Incidence of Rotavirus Hospitalization in Children Living in Defined Regions of Akita and Kyoto Prefectures, Japan

et al. 2017

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SUMMARY: Variable incidence rates of rotavirus gastroenteritis hospitalizations have been reported in Japan. However, it is not known whether the observed regional differences were due to the real difference in the occurrence of severe disease or other causes. This study aimed to determine the incidence rates of rotavirus hospitalization among children aged ＜5 years in the Yuri district in Akita prefecture and the Nantan district in Kyoto prefecture between March 2012 and February 2013. During this period, rotavirus vaccine uptake rates were equally low in both regions. All specimens were evaluated using the standardized case definition, severity scores, and the same assays. There were 44 rotavirus cases (44z) among 101 acute gastroenteritis-related hospitalizations in the Yuri district with a catchment population of 3,853, and 18 rotavirus cases (47z) among 38 acute gastroenteritis-related hospitalizations in the Nantan district with a catchment population of 5,128. While the severity score at the time of the hospitalizations was 11 in both hospitals, the incidence rates in Akita and Kyoto were 11.7 (95z confidence interval [CI]: 8.5-15.6) and 3.9 (95z CI: 2.1-5.5) per 1,000 child-years, respectively. Thus, there was a real difference in the occurrence rate of severe rotavirus infections between the 2 regions.

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Section: Discussionsupporting

confidence: 89%

Regional Variations in the Incidence of Rotavirus Hospitalization in Children Living in Defined Regions of Akita and Kyoto Prefectures, Japan

et al. 2017

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“…In several studies, the rapid spread and predominance of unusual DS-1-like G1P [8] rotavirus were reported during 2011-2013 in various locations across Japan. The increase in G1P [8] strains after vaccine introduction in Tsu City and Kurashiki City may be related to an increase in this unusual strain (14)(15)(16). On the other hand, the genotype distribution was quite different in Isumi City.…”

Section: Discussionmentioning

confidence: 94%

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

et al. 2017

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“…The migration profile of RNA segments of RVAs on PAGE is termed the electropherotype, and two major RNA migration patterns, long and short, are differentiated based on the migration rate of the NSP5 gene. Interestingly, G1P[8] (Japan) and G3P[8] (Australia and Thailand) with a short RNA pattern emerged in 2012 and 2013, respectively, and whole genomic analysis showed that the G1P[8] and G3P[8] strains with a short RNA profile had a DS‐1‐like genetic backbone: a G1 or G3‐P[8]‐I2‐R2‐C2‐M2‐A2‐N1/2‐T2‐E2‐H2 genome constellation . G3P[8] strains with a short RNA profile are described as DS‐1‐like (equine‐like) G3P[8] strains since their VP7 gene sequences are highly related to those of RVAs detected in horses .…”

Section: Introductionmentioning

confidence: 99%

High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

Tacharoenmuang

Komoto

Guntapong

et al. 2019

Journal of Medical Virology

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Group A rotavirus (RVA) is a major cause of acute gastroenteritis in infants and young children worldwide. This study aims to clarify the distribution of G/P types and genetic characteristics of RVAs circulating in Thailand. Between January 2014 and September 2016, 1867 stool specimens were collected from children and adults with acute gastroenteritis in six provinces in Thailand. RVAs were detected in 514/1867 (27.5%) stool specimens. G1P[8] (44.7%) was the most predominant genotype, followed by G3P[8] (33.7%), G2P[4] (11.5%), G8P[8] (7.0%), and G9P[8] (1.3%). Unusual G3P[9] (0.8%), G3P[10] (0.4%), G4P[6] (0.4%), and G10P[14] (0.2%) were also detected at low frequencies. The predominant genotype, G1P[8] (64.4%), in 2014 decreased to 6.1% in 2016. In contrast, the frequency of G3P[8] markedly increased from 5.5% in 2014 to 65.3% in 2015 and 89.8% in 2016. On polyacrylamide gel electrophoresis, most (135/140; 96.4%) of the G3P[8] strains exhibited a short RNA profile. Successful determination of the nucleotide sequences of the VP7 genes of 98 G3P[8] strains with a short RNA profile showed that they are all equine‐like G3P[8] strains. On phylogenetic analysis of genome segments of two representative Thai equine‐like G3P[8] strains, it was noteworthy that they possessed distinct NSP4 genes, one bovine‐like and the other human‐like. Thus, we found that characteristic equine‐like G3P[8] strains with a short RNA electropherotype are becoming highly prevalent in children and adults in Thailand.

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Spread and predominance in Japan of novel G1P[8] double-reassortant rotavirus strains possessing a DS-1-like genotype constellation typical of G2P[4] strains

Cited by 60 publications

References 35 publications

Regional Variations in the Incidence of Rotavirus Hospitalization in Children Living in Defined Regions of Akita and Kyoto Prefectures, Japan

Regional Variations in the Incidence of Rotavirus Hospitalization in Children Living in Defined Regions of Akita and Kyoto Prefectures, Japan

Changes in Rotavirus Genotypes before and after Vaccine Introduction: a Multicenter, Prospective Observational Study in Three Areas of Japan

High prevalence of equine‐like G3P[8] rotavirus in children and adults with acute gastroenteritis in Thailand

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