Spread of extended-spectrum β-lactamase genes of bla OXA-10, bla PER-1 and bla CTX-M in Pseudomonas aeruginosa strains isolated from burn patients

Farshadzadeh, Zahra; Khosravi, Azar Dokht; Alavi, Seyed Mohammad; Parhizgari, Najmeh; Hoveizavi, Hajar

doi:10.1016/j.burns.2014.02.008

Cited by 34 publications

(27 citation statements)

References 20 publications

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“…Analysis of P. aeruginosa isolates from the burn ward of a hospital in Khuzestan showed that 176 (95.13%) isolates were MDR, and the prevalence of ESBL was higher than that of a similar study in Yazd Province (Farshadzadeh et al, 2014). During the study period between 2009 and 2010 in Fars Province, K. pneumoniae was collected from Intensive Care Units (ICUs) of Namazi Hospital in Shiraz and high prevalence (60%) of ESBL-producing K. pneumonia were demonstrated.…”

Section: Southern Part Of Iranmentioning

confidence: 58%

Extended-Spectrum Beta-Lactamase Producing Gram Negative Bacteria in Iran: A Review

Leylabadlo¹,

Pourlak²,

Bialvaei³

et al. 2017

AJID

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Background: The emergence and spread of extended spectrum β-lactamase (ESBL)-producing Gram-negative bacteria (GNB), particularly in Enterobacteriaceae, Acinetobacter baumannii, and Pseudomonas aeruginosa, have increased all over the world. ESBLs are characterized by their ability to hydrolyze β-lactams, early cephalosporins, oxyimino-thiazolyl cephalosporins, and monobactams, but not cephamycins or carbapenems. The rate of nosocomial infections caused by ESBL-producing GNB in Asia Pacific has increased and several studies have identified their prevalence in the region. The aim of this study is to review the prevalence of ESBL-producing GNB in the West Asia and the Middle East with a particular focus on Iran. Materials and Methods: The available evidence from various studies (Microbia and clinical studies, retrieved from the PubMed, and Scopus databases) regarding the ESBL producing Gram negative bacteria in Iran were evaluated. Results:In almost all parts of the country, high resistance has been observed, especially in the central part of Iran. Up to 89.8% Escherichia coli, 72.1% Klebsiella pneumonia, 84.2% Acinetobacter baumannii, and 83.8% Pseudomonas aeruginosa isolates are ESBL positive. Conclusion:The present study showed the increasing prevalence of ESBLs in different regions of Iran, which could be useful to strategic policy towards reducing reduce their prevalence.

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Section: Southern Part Of Iranmentioning

confidence: 58%

Extended-Spectrum Beta-Lactamase Producing Gram Negative Bacteria in Iran: A Review

Leylabadlo¹,

Pourlak²,

Bialvaei³

et al. 2017

AJID

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“…The treatment of infections caused by these resistant organisms is increasingly complicated owing to the high levels of resistance to the most commonly prescribed antibiotics in hospital settings 27 . Several studies carried out by Mirsalehian et al 28 , Farshadzadeh et al 29 , and Shakibaie et al 30 covering three ESBL: extended spectrum β-lactamase.…”

Section: Discussionmentioning

confidence: 99%

“…Farshadzadeh et al, in a study carried out at the Taleghani Burn Hospital in Ahvaz (Iran), reported that 54.2% and 68.7% of ESBL-producing isolates of P. aeruginosa harbored bla PER-1 and bla OXA-10 , respectively 29 . Among the studies reported from Asian countries, Lee and colleagues from South Korea showed that 6.3%, 13.1%, 4.3%, 2.0%, 2.3%, and 0.4% of P. aeruginosa isolates carried the bla PSE-1 , bla , bla OXA-4 , bla OXA-30 , bla OXA-2 , and bla OXA-17 genes, respectively 36 .…”

mentioning

confidence: 99%

Distribution of the bla OXA , bla VEB-1 , and bla GES-1 genes and resistance patterns of ESBL-producing Pseudomonas aeruginosa isolated from hospitals in Tehran and Qazvin, Iran

Amirkamali

Naserpour-Farivar

Azarhoosh

et al. 2017

Rev. Soc. Bras. Med. Trop.

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Introduction:Pseudomonas aeruginosa is one of the most common nosocomial pathogens. The emergence of extended spectrum β-lactamases (ESBLs) has been increasingly reported as a major clinical concern worldwide. The main aim of the present study was to determine the distribution of bla OXA , bla PER-1, bla VEB-1, and bla GES-1 genes among ESBL-producing P. aeruginosa isolated from two distinct provinces in Iran. Methods: In this study, a total of 75 (27.5%) ESBL-producing isolates were identified from 273 P. aeruginosa isolates collected from patients in Qazvin and Tehran. Phenotypic detection of ESBLs and antimicrobial susceptibility testing were performed according to the Clinical and Laboratory Standards Institute guidelines. PCR and sequencing were employed to detect bla OXA-1 , bla OXA , bla GES-1, bla PER-1 , and bla VEB-1 genes. Isolate genetic relationships were evaluated by repetitive extragenic palindromic sequence-based PCR (REP-PCR). Results: In total, 59 (78.7%) of the ESBLproducing isolates showed multidrug resistance. The highest rates of susceptibility were observed against colistin (75 isolates, 100%) and polymyxin B (75, 100%) followed by amikacin (44, 58.7%), and piperacillin-tazobactam (40, 53.3%). The bla OXA-1 (37.3%) gene was the most common of the genes investigated, followed by bla OXA-4 (32%), bla GES-1 (16%), and bla VEB-1 (13.3%). REP-PCR identified three different genotypes: types A (89.3%), B (6.7%), and C (4%). Conclusions: We found a significant presence of bla OXA-1 , bla OXA-4 , bla GES-1, and bla VEB-1 genes among P. aeruginosa isolates, highlighting the need for suitable infection control strategies to effectively treat patients and prevent the further distribution of these resistant organisms.

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“…Skin is regarded as the first line defense against pathogens exposure; however, any thermal injury results in physical barrier disruption leading to pathogen invasion. Hence, skin damage along with compromised blood supply around wound and immunodeficiency increase acquisition of nosocomial infection in burn patients [1,7-resistant strains thus limiting therapeutic options [3,13,[16][17][18][19]. The primary cause for production of multiple drug resistant strains is β-lactamases particularly extended spectrum β-lactamases (ESBL) whose incidence is steadily increasing all over the world [9,16,[19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

Hussain¹,

Munir²,

Fatima³

et al. 2017

APJTD

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Spread of extended-spectrum β-lactamase genes of bla OXA-10, bla PER-1 and bla CTX-M in Pseudomonas aeruginosa strains isolated from burn patients

Cited by 34 publications

References 20 publications

Extended-Spectrum Beta-Lactamase Producing Gram Negative Bacteria in Iran: A Review

Extended-Spectrum Beta-Lactamase Producing Gram Negative Bacteria in Iran: A Review

Distribution of the bla OXA , bla VEB-1 , and bla GES-1 genes and resistance patterns of ESBL-producing Pseudomonas aeruginosa isolated from hospitals in Tehran and Qazvin, Iran

Antimicrobial susceptibility patterns and CTX-M β-lactamase producing clinical isolates from burn patients in Islamabad, Pakistan

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