Spread of Nickel Dermatitis

Systemic Contact Dermatitis

“…Many patients with severe suspender dermatitis in the 1950s and 1960s had widespread dermatitis, with vesicular hand eczema and flexural dermatitis similar to that seen in systemic contact dermatitis [22,23]. Systemic exposure from the absorption of nickel in the area of the dermatitis was thought to explain the clinical picture.…”

Pseudo-Atopic Dermatitis

“…Since it has been mentioned in the dermatological literature that a number of patients with sensitivity to nickel may present a clinical picture resembling that described here as due to chromate sensitivity [2,11], it is suggested that the name Pseudo-Atopic Dermatitis might in future be extended to include similar clinical pictures resulting from sensitivity to other metals.…”

Nickel earlobe dermatitis and clinical non‐relevance of the oral exposure

“…9 However, the pathogenetic role of nickel in the diet (200-600 μ g daily) is under debate, and a dietary requirement of 50 μ g per day has been proposed. 10 Modern analytical studies have estimated that the average human daily intake of nickel is approximately 200 μ g. 11 Furthermore, previous studies reported that 5 to 10 mg of nickel sulphate was employed for oral challenge, and only few sensitized patients showed a disease flare-up. Because nickel dietary restrictions are commonly imposed on many patients with earlobe dermatitis due to nickel hypersensitivity, the aim of this study was to identify the role of occasional and extended oral nickel exposure in these patients.…”