Binary-collision-approximation-based (BCA-based) simulation is performed for the investigation of the effect of a polycrystalline structure on the penetration depth, absorption rate, and sputtering yield of tungsten materials irradiated by helium plasma. To clarify the possibility of suppressing the generation of helium bubbles in tungsten materials by designing the properties of the polycrystalline structure, such as grain size, the effect of the polycrystalline structure on helium bubble formation is also investigated.