Sputum periostin in patients with different severe asthma phenotypes

Bobolea, Irina; Paredes, Pilar; Pozo, Victoria del; Romero, David; Sanz, Verónica; López-Carrasco, Valentín; Canabal, J.; Villasante, C.; Quirce, Santiago

doi:10.1111/all.12580

Cited by 75 publications

(75 citation statements)

References 25 publications

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“…This is in contrast to studies assessing periostin in induced sputum, which demonstrated the association of periostin levels with asthma severity or the presence of fixed bronchial obstruction as well as with the percentage of eosinophils in the blood and sputum2023 However, our asthmatic patients with CRS who reported symptoms during the previous 3 months had on average 50% higher levels of periostin in EBC than those without. Patients with and without CRS symptoms were similar with respect to all clinical/pathophysiological features of asthma, including severity, asthma control, or spirometry.…”

Section: Discussioncontrasting

confidence: 99%

“…Concentrations of periostin were similar in EBC, as well as in serum, collected from patients with asthma and healthy individuals, which is difficult to explain because in previous studies increased levels of this molecule have been found in induced sputum and were associated with eosinophilic airway inflammation 20. It seems likely that EBC and serum levels of periostin in our asthma patients were affected by chronic asthma treatment.…”

Section: Discussionsupporting

confidence: 52%

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Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease

Wardzyńska

Makowska

Pawełczyk

et al. 2017

Allergy Asthma Immunol Res

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PurposePeriostin is considered a biomarker for eosinophilic airway inflammation and have been associated with NSAID-Exacerbated Respiratory Disease (NERD) and chronic rhinosinusitis (CRS). In this study, we aimed to evaluate periostin in exhaled breath condensate (EBC) and in serum of patients with various asthma phenotypes.MethodsThe study included 40 asthmatic patients (22 with NERD) and 17 healthy controls. All the procedures (questionnaire, spirometry, FeNO, nasal swabs, EBC collecting, and blood sampling) were performed on the same day. Periostin concentrations were measured using an ELISA kit.ResultsPeriostin was detected in EBC from 37 of 40 asthmatics and in 16 from 17 of controls. The concentration of periostin in EBC did not differ between the study groups and was not associated with NERD or asthma severity. However, the EBC periostin was significantly higher in asthmatics with CRS as compared to those without (3.1 vs 2 ng/mL, P=0.046). Patients with positive bacterial culture from nasal swabs had higher EBC periostin concentrations than those without (3.2 vs 2.1 ng/mL; P=0.046). The mean serum periostin level was higher in asthmatics with a 1-year history of exacerbation than in those without (3.2 vs 2.3 ng/mL, P=0.045). Asthmatics with skin manifestation of NSAIDs hypersensitivity had higher serum periostin levels as compared to those without (3.5 vs 2.3 ng/mL; P=0.03).ConclusionsEBC periostin levels seem to reflect intensity of upper airway disease in asthmatics, while serum levels of periostin are associated with asthma activity (exacerbations or FeNO) or NERD subphenotypes.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 52%

Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease

Wardzyńska

Makowska

Pawełczyk

et al. 2017

Allergy Asthma Immunol Res

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“…Bobolea et al46 showed a good correlation of sputum periostin with late-onset asthma. It is generally known that late-onset asthma is eosinophil-dominant and is more often non-atopic than childhood asthma 47.…”

Section: Introductionmentioning

confidence: 95%

Using Periostin as a Biomarker in the Treatment of Asthma

Izuhara

Ohta

Ono

2016

Allergy Asthma Immunol Res

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Periostin acts both as an extracellular matrix protein belonging to the fasciclin family and as a matricellular protein functioning in cell activation by binding to its receptors on the cell surface. It has been established that periostin is a downstream molecule of interleukin (IL)-13, a signature type 2 cytokine, and that periostin plays an important role in the pathogenesis of allergic diseases, including asthma. Based on these findings, much attention has been paid to periostin as a biomarker useful in the treatment of asthma. Periostin is a surrogate biomarker for type 2 immunity; it has been shown that serum periostin can predict the efficacy of anti-IL-13 antibodies (lebrikizumab) and anti-IgE antibodies (omalizumab), and that this usefulness can be potentially expanded to other type 2 antagonists. Moreover, it has been shown that periostin is not a simple surrogate biomarker for type 2 immunity; periostin-high asthma patients have several unique characteristics, including eosinophilia, high fraction of nitric oxide, aspirin intolerance, nasal disorders, and late onset. These characteristics are likely to be correlated with the involvement of periostin in the tissue remodeling of asthma. Periostin is also associated with hyporesponsiveness to inhaled corticosteroids, probably reflecting tissue remodeling. Thus, periostin has 2 characteristics as a biomarker for early diagnosis of asthma: surrogate biomarkers for type 2 immunity and tissue remodeling. Based on these characteristics, we will be able to apply serum periostin to treatment of asthma.

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“…According to some authors, this protein is a safe and stable biomarker of chronic inflammation [17] and of the T H 2 mechanism underlying severe asthma in adults [10]. A link has been established between periostin and bronchial obstruction, elevated levels of fractional exhaled nitric oxide (FeNO), and eosinophil count in adults [18][19][20]. One of the effects of periostin is to attract inflammatory cells-neutrophils or eosinophils-to the airway.…”

Section: Introductionmentioning

confidence: 99%

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

Mena

Abejón

Vidigal

et al. 2017

J Investig Allergol Clin Immunol

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Background: Asthma is the most common chronic disease in children. Cases of severe asthma (SA) are underdiagnosed. Periostin is a biomarker for SA in adults, but its role in children is poorly understood. Objectives: The aims of the study were to estimate the percentage of cases of uncontrolled severe asthma (UcSA) in children with poorly controlled asthma and to evaluate the role of periostin as a biomarker. Materials and Methods: We performed an observational study in children aged 5 to 14 years with poorly controlled asthma. Demographic and clinical data were collected in addition to the results of the lung function test, the fraction of exhaled nitric oxide, the skin prick test, total IgE, specific IgE, blood eosinophil count, serum periostin, treatment, asthma control, and quality of life. Variables were compared between the group with UcSA and the other children. Results: Fifty children with poorly controlled asthma (72% male) were included. Nineteen children (38%) had UcSA. Most children had limitations in their activities of daily living and had visited the emergency department. In addition, 38% were hospitalized. Quality of life was poor. Only 42% of the children received appropriate treatment. The UcSA group was more likely to have a total IgE >500 kU A /mL (52.6% vs 19%, P=.02) and less likely to have serum periostin >1000 ng/mL (31.2% vs 63%, P=.04). Conclusions: In our setting, 38% of children with poorly controlled asthma have UcSA, which is associated with higher levels of total serum IgE and lower levels of serum periostin.

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Sputum periostin in patients with different severe asthma phenotypes

Abstract: This study demonstrates the utility of periostin in phenotyping severe asthma. Periostin levels in sputum are associated with persistent airflow limitation in asthma patients with airway eosinophilia despite treatment with high-dose inhaled corticosteroids.

Cited by 75 publications

References 25 publications

Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease

Periostin in Exhaled Breath Condensate and in Serum of Asthmatic Patients: Relationship to Upper and Lower Airway Disease

Using Periostin as a Biomarker in the Treatment of Asthma

Role of Periostin in Uncontrolled Asthma in Children (DADO study)

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