Squamous carcinoma of the breast.

Hasleton, P S; Misch, K. A.; Vasudev, K S; George, David W.

doi:10.1136/jcp.31.2.116

Cited by 49 publications

(21 citation statements)

References 13 publications

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“…The problem lies in defining the origin of squamous cell carcinoma of the breast tissue. Although its origin was though to be squamous metaplastic ductal epithelium 1,2 or squamous cell metaplasia of adenocarcinoma, 3 most of the adenocarcinomatous component of our patient's tumor was noninvasive cancer. Therefore, it was not identified as metaplasia of invasive adenocarcinoma, as reported previously.…”

Section: Discussionmentioning

confidence: 86%

Recurrent Squamous Cell Carcinoma of the Breast with Undifferentiated Features: Report of a Case

et al. 2002

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Squamous cell carcinoma of the breast is a rare type of cancer, the origin of which is still uncertain. We report a case of squamous cell carcinoma of the breast with a recurrent tumor that showed undifferentiated features. The patient was a 55-year-old woman who originally presented with a left breast mass in the upper outer quadrant. Echography showed a 46 x 29 x 23-mm mass with cavity formation, and aspiration cytology confirmed a diagnosis of squamous cell carcinoma. A modified radical mastectomy with level III lymph node dissection was performed. Pathologically, the tumor was composed of squamous cell carcinoma and noninvasive ductal carcinoma. A recurrent tumor showing undifferentiated features was detected in the left forechest 3 months after the operation, and tumorectomy with partial resection of the major and minor pectoralis muscles was performed. Despite intensive therapy including chemotherapy (CEF: cyclophosphamide, epirubicin, 5-fluorouracil) and irradiation (50 Gy), the patient died from pulmonary and skin metastases 20 months after her initial operation. The squamous cell carcinoma of the breast in this patient grew rapidly and her prognosis was poor. Immunohistochemical findings indicated the possibility that the squamous cell carcinoma developed from noninvasive ductal carcinoma of the comedo type, and that the undifferentiated cells from the site of recurrence developed from dedifferentiation of the squamous cell carcinoma.

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Section: Discussionmentioning

confidence: 86%

Recurrent Squamous Cell Carcinoma of the Breast with Undifferentiated Features: Report of a Case

et al. 2002

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“…It appears, as the name implies, that it is not a pure squamous cell carcinoma, but rather an adenocarcinoma with squamous metaplasia as previously often described [3,4,8,. Of interest is the association of squamous metaplasia with adenomas [3,10] leading possibly to invasive squamous cell carcinomas.…”

Section: Discussionmentioning

confidence: 89%

Pure squamous cell carcinoma of the breast

Lafrenière

Moskowitz

Ketcham

1986

Journal of Surgical Oncology

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Pathological curiosities have always fascinated the surgical community, and management of breast cancer by the physician has, at times, revealed such rarities. A recent case of squamous cell carcinoma in a clear fluid breast cyst has prompted a review of our experience with this rare pathology, and allowed us to make the following statements: We propose that squamous cell carcinoma of the breast arises from ductal metaplasia. When the T.N.M. system is applied to the squamous cell lesion, the apparent poor prognosis that it is believed to carry may not be so apparent. If no other primaries are identified after extensive metastatic work-up, surgical therapy consisting of total mastectomy with complete axillary dissection, is very effective in local control of tumor progress. Nodal status will indicate the need for additional modalities of therapy.

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“…[78] The benign breast conditions with abundant squamous cells may sometimes mimic malignant squamous lesion and vice versa. In general, the presence of abundant foamy macrophages in the background suggests a benign lesion.…”

Section: Discussionmentioning

confidence: 99%

Primary intracystic squamous cell carcinoma of the breast: A case report and review of the literature

Teerthanath

Krishna

2009

J Cytol

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Primary intracystic squamous cell carcinoma (SCC) of the breast is an extremely rare entity and has a low incidence in comparison with other breast cancers. We report a rare case of primary intracystic SCC in a 45-year-old woman who presented with a cystic lump in the right breast. Cytological smears of the fluid aspirated from the breast tumor revealed malignant squamous cells dispersed in single and occasional groups along with numerous cyst macrophages, suggesting cystic SCC. Histological study of the mastectomy specimen confirmed the diagnosis of primary intracystic SCC. Although the presence of abundant foamy macrophages in the background of fine needle aspiration cytology smears of the breast suggest benign breast lesion, when associated with malignant squamous cells, these suggest cystic primary SCC or metastatic SCC. The primary SCC should not be confused with metaplastic change in other breast carcinomas.

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Squamous carcinoma of the breast.

Cited by 49 publications

References 13 publications

Recurrent Squamous Cell Carcinoma of the Breast with Undifferentiated Features: Report of a Case

Recurrent Squamous Cell Carcinoma of the Breast with Undifferentiated Features: Report of a Case

Pure squamous cell carcinoma of the breast

Primary intracystic squamous cell carcinoma of the breast: A case report and review of the literature

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