Squamous carcinoma of the hypopharynx in children in Sénégal: Between disarray and enigma

Ndiaye, I.C.; Diom, Evelyne Siga; Diop, Fatou; Tall, A; Ndiaye, M.; Essalki, I; Déguénonvo, R.; Diallo, B.K.; Diouf, R.; Diop, E. M.

doi:10.1016/j.ijporl.2008.10.032

Cited by 9 publications

(12 citation statements)

References 5 publications

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“…61,72 Two studies from Senegal discussed HP SCC, including a study of 66 patients (0.8% of all cases), aged 10 to 86 years, with a mean age of 33, 74 and a study of 15 children, aged 10 to 18 years, with a mean age of 15. 75 The aggregate maleto-female ratio was 0.9:1. Lesion subsite was recorded for all patients; 30 (37%) were pyriform sinus, 18 (22%) were posterior pharyngeal wall, seven (9%) were oesophageal introitus, four (5%) were postcricoid, and 22 (27%) were too advanced to determine a primary subsite.…”

Section: Demographics Anatomic Sites and Histologymentioning

confidence: 95%

“…Data regarding tobacco and alcohol use were available for 335 (87%) of the 385 patients with laryngeal SCC and demonstrated that 56% of patients used tobacco and 56% used alcohol (Table 4). Among hypopharyngeal SCCs, one study of 15 patients (aged 10 to 18 years) noted that no patient used tobacco or alcohol, 75 while another study noted that 13 (20%) of 66 of patients used tobacco, with alcohol use not reported. 74 Duration and amount of use was not consistently reported, and no study specified how tobacco or alcohol use was determined.…”

Section: Substance Usementioning

confidence: 99%

“…One study of 15 hypopharyngeal SCCs noted that one patient had severe oral and labial papillomatosis, although HPV confirmatory testing was not performed. 75 …”

Section: Hiv and Hpvmentioning

confidence: 99%

“…70 Rates of mucositis, malnutrition, and infectious complications, common causes of treatment-related morbidity in resourcerich settings, were not reported in any study. Among HP SCCs, 74,75 two patients (3%) underwent surgery followed by radiation, three patients (4%) underwent surgery alone and 28 patients (35%) underwent radiation alone, while 48 (59%) underwent only palliative tracheostomy or gastrostomy. Within three years of follow-up, 77 patients (95%) had died and the remaining four (5%) were lost to follow-up.…”

Section: Staging Treatment and Outcomementioning

confidence: 99%

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Review: Head and neck squamous cell carcinoma in sub-Saharan Africa

Faggons¹,

Mabedi²,

Shores³

et al. 2015

Mal. Med. J

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AimReview the literature from 1990 to 2013 to determine known anatomic sites, risk factors, treatments, and outcomes of head and neck squamous cell carcinoma (HNSCC) in sub-Saharan Africa. MethodsUsing a systematic search strategy, literature pertaining to HNSCC in sub-Saharan Africa was reviewed and patient demographics, anatomic sites, histology, stage, treatment, and outcomes were abstracted. The contributions of human immunodeficiency virus (HIV), human papillomavirus (HPV) and behavioural risk factors to HNSCC in the region were assessed. ResultsOf the 342 papers identified, 46 were utilized for review, including 8611 patients. In sub-Saharan Africa, the oropharyngeal/oral cavity was found to be the most common site, with 7750 cases (90% of all cases). Few papers distinguished oropharyngeal from oral cavity, making identification of possible HPV-associated oropharyngeal squamous cell carcinoma (SCC) difficult. SCC of the nasopharynx, nasal cavity, or paranasal sinuses was identified in 410 patients (4.8% of all cases). Laryngeal SCC was found in 385 patients (4.5% of all cases), and only 66 patients (0.8% of all cases) with hypopharyngeal SCC were identified. In 862 patients with data available, 43% used tobacco and 42% used alcohol, and reported use varied widely and was more common in laryngeal SCC than that of the oropharyngeal/oral cavity. Toombak and kola nut use was reported to be higher in patients with HNSCC. Several papers reported HIV-positive patients with HNSCC, but it was not possible to determine HNSCC prevalence in HIV-positive compared to negative patients. Reports of treatment and outcomes were rare. ConclusionsThe oropharyngeal/oral cavity was by far the most commonly reported site of HNSCC reported in sub-Saharan Africa. The roles of risk factors in HNSCC incidence in sub-Saharan Africa were difficult to delineate from the available studies, but a majority of patients did not use tobacco and alcohol.

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Section: Demographics Anatomic Sites and Histologymentioning

confidence: 95%

Section: Substance Usementioning

confidence: 99%

“…One study of 15 hypopharyngeal SCCs noted that one patient had severe oral and labial papillomatosis, although HPV confirmatory testing was not performed. 75 …”

Section: Hiv and Hpvmentioning

confidence: 99%

Section: Staging Treatment and Outcomementioning

confidence: 99%

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