Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis

Kikkawa, Fumitaka; Ishikawa, Hisatake; Koji, Takehiko; Nawa, Akihiro; Suganuma, Nobuhiko; Tsutsumi, Yutaka

doi:10.1016/s0029-7844(97)00117-8

Cited by 104 publications

(93 citation statements)

References 12 publications

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“…Ek olarak malign transformasyon riskini öngörebilecek henüz net bir bulgu veya yöntem mevcut değildir (3,4). Ancak literatürde tümör çapının 9.9 cm'den büyük olmasının %86 oranında malignite açısından sensitif olduğu bildirilmiştir (6 …”

Section: Discussionunclassified

Matür kistik teratom zemininde gelişmiş sigmoid kolona fistülize olan skuamöz hücreli karsinom

Şahin¹,

Kılıç²,

Seçkin³

et al. 2015

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ÖzMatür kistik teratom overin en sık germ hücreli tümörü olup genellikle reprodüktif çağda görülmektedir. Matür kistik teratom benign bir tümör olmasına rağmen nadiren (%1-2 oranında) malign transformasyon gösterebilmekte ve genellikle ileri yaşlarda ortaya çıkmaktadır. Matür kistik teratomda görülen en sık malign transformasyon skuamöz hücreli karsinomdur (%70-80). Malign transformasyon gösteren matür kistik teratom lokal invazyon ve peritoneal ekim yolu ile komşu organlara yayılım gösterebilmekte ve etkilenen organlara ait klinik semptom verebilmektedir. Biz burada 82 yaşında hastaya ait kolona fistülizasyon gösteren matür kistik teratom zemininde gelişmiş bir skuamöz hücreli karsinom olgusunu sunuyoruz.Anahtar Sözcükler: Malign transformasyon, matür kistik teratom, over. Abstract Mature cystic teratoma is the most common germ cell tumor of the ovary that generally occurs during reproductive period. Although mature cystic teratoma is a benign tumor, rarely (1-2%) it may show malignant transformation and it is usually observed in older ages. Squamous cell carcinoma is the most common malignant transformation (70-80%

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Section: Discussionunclassified

Matür kistik teratom zemininde gelişmiş sigmoid kolona fistülize olan skuamöz hücreli karsinom

Şahin¹,

Kılıç²,

Seçkin³

et al. 2015

Ege Tıp Dergisi

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“…Gastrointestinal symptoms, rectal bleeding, or urinary frequency are various symptoms described and related to MCTs and they are attributed to invasion of nearby organs (4). The mean size of MCTs is 6-9 cm compared to malignant transformed MCTs which tend to have a larger size with an average mean size of 15cm (15,16). Kikkawa et al reported that a tumor size greater than 9.9 cm has a 86% sensitivity for malignancy (13).…”

Section: Discussionmentioning

confidence: 99%

“…In most cases it is not diagnosed preoperatively (16,18,19). The use of tumor markers as a diagnostic tool to discriminate MCTs and SCCs arising from an MCT is difficult to help since most of them are raised in both situations (2).…”

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confidence: 99%

A rare case report of squamous-cell carcinoma arising from mature cystic teratoma of ovary

Kalampokas¹

2014

gchir

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“…Larger size (>9.9cm) correlates with increased risk of malignant transformation. Prognostic indicators include FIGO staging, tumor rupture, vascular invasion and histological type of tumor 9 . Serum tumor markers (SCC-Ag &CEA) are mandatory for all such lesions.. Malignant tumors arising in a mature cystic teratoma spread by direct & local invasion rather than by lymphatic & hematogenous dissemination.…”

Section: Case Reportmentioning

confidence: 99%

Squamous Cell Carcinoma Arising In Mature Cystic Teratoma - A Rare Case Report

2016

IJSR

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Introduction: Germ cell tumors account for approximately 30% of all ovarian tumors. Ninety-five percent of germ cell tumors are dermoid cyst (mature cystic teratoma). It is composed of mature tissues derived from 3 germ cell layers (ectoderm, mesoderm, and endoderm). Malignant transformation in a mature cystic teratoma of the ovary is a rare event, developing in 1 to 2 % of cases and is associated with a poor prognosis. It occurs mostly in post menopausal females. The most common malignancy is squamous cell carcinoma (75%), followed by adenocarcinoma and melanoma. Case Report: In the present case, a patient presented with complaints of pain abdomen and abdominal distension since 2 months. USG and CT scan revealed large multinucleated solid cystic mass likely solid ovarian malignancy.CA 125 was within normal limits. On Laprotomy, there was big abdominal pelvic mass adherent to gut loops. Left ovary was replaced with this big cystic mass. On debulking of cystic growth, pus admixed with blood was present. On histopathological examination, keratinizing squamous cell carcinoma arising in mature cystic teratoma with invasion into myometrium was diagnosed. Summary and Conclusion: SCC arising from a mature cystic teratoma is a rare pathologic event and in most instances not diagnosed preoperatively. There are no particular signs or symptoms which are characteristic of malignancy arising in a dermoid cyst. The risk factors for malignancy in mature cystic teratoma include age and tumor size. The patients with metastasis have a very poor prognosis.

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Squamous cell carcinoma arising from mature cystic teratoma of the ovary: A clinicopathologic analysis

Cited by 104 publications

References 12 publications

Matür kistik teratom zemininde gelişmiş sigmoid kolona fistülize olan skuamöz hücreli karsinom

Matür kistik teratom zemininde gelişmiş sigmoid kolona fistülize olan skuamöz hücreli karsinom

A rare case report of squamous-cell carcinoma arising from mature cystic teratoma of ovary

Squamous Cell Carcinoma Arising In Mature Cystic Teratoma - A Rare Case Report

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